InSolution Roscovitine - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A potent and selective inhibitor of cyclin-dependent kinases (Cdks). Exhibits greater inhibitory potency compared to olomoucine (Cat. No. 495620). Inhibits p34 Cdc2/cyclin B (IC
50 = 650 nM), p33 Cdk2/cyclin A (IC
50 = 700 nM), p33 Cdk2/cyclin E (IC
50 = 700 nM), and p33 Cdk2/p35 (IC
50 = 200 nM) by competing for the ATP binding domain of these kinases. Exhibits very low sensitivity towards related kinases, such as Erk1 and Erk2 (IC
50 = 34 μM and 14 μM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 μM and compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G
1/S and G
2/M phases of the cell cycle.
Biochem/physiol Actions
Reversible: yes
InSolution Roscovitine - Calbiochem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
