CHK2 INHIBITOR II

516480-79-8

CAS-Nr.: 516480-79-8

Englisch Name:: CHK2 INHIBITOR II

Synonyma:: C 3742;BML-277;CS-1761;BML-277, >98%;Chk2InhibitorⅡ;C 3742 BML-277;BML-277 (C 3742);Chk2 Inhibitor II hydrate;BML-277,CHK2 INHIBITOR II;Chk2 Inhibitor II (BML-277)

CBNumber:: CB9503256

Summenformel:: C20H14ClN3O2

Molgewicht:: 363.8

MOL-Datei:: 516480-79-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 96

CHK2 INHIBITOR II Eigenschaften

Siedepunkt:: 637.1±63.0 °C(Predicted)

Dichte: 1.390±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO: 18 mg/mL

Aggregatzustand: solid

pka: 10.40±0.10(Predicted)

Farbe: tan

Stabilität:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

WGK Germany	3

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P261	Einatmen von Staub vermeiden.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

CHK2 INHIBITOR II Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC₅₀ = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC₅₀ = 3-7.6 μM). This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.

Verwenden

Chk2 Inhibitor II is a selective APT-competitive inhibitors of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2).

Biochem/physiol Actions

Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).

CHK2 INHIBITOR II Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

CHK2 INHIBITOR II Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 96)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

516480-79-8()Verwandte Suche:

Fluoruracil m-Aminobenzamid

C 3742
BML-277
2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE
2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-5-carboxylic acid amide
C 3742 BML-277
InSolution? Chk2 Inhibitor II
2-[4-(4-chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide
2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
Chk2 Inhibitor II hydrate
2-(4-(4-CHLOROPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE, >98%
BML-277, >98%
BML-277 (C 3742)
CS-1761
BML-277,CHK2 INHIBITOR II
CHK2 INHIBITOR II; C 3742; BML277; BML 277
Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
InSolution Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide
Chk2 Inhibitor II (BML-277)
1H-Benzimidazole-6-carboxamide, 2-[4-(4-chlorophenoxy)phenyl]-
2-(4-(4-Chlorophenoxy)phenyl)-1H-benzo[d]imidazole-6-carboxamide
inhibit,Checkpoint Kinase (Chk),Inhibitor,BML277,BML-277,Apoptosis
Chk2InhibitorⅡ
516480-79-8
Inhibitors
API