Nizatidine Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Nizatidine is the fifth H
2-antagonist introduced to the world market as an antiulcer agent.
It is reported to be effective in the treatment of both duodenal and gastric ulcers or the
prevention of their recurrences. Given once-daily, nizatidine’s bioavailability is not
diminished by the concurrent administration of an antacid.
Chemische Eigenschaften
White Crystalline Powder
Verwenden
Nizatidine is used for treating stomach and duodenum
ulcers and other conditions accompanied by elevated acidity of the gastrointestinal tract.
Indications
Nizatidine is the newest H2-receptor antagonist.
Similar to ranitidine, it has a relative potency twice that
of cimetidine.About 90% of an oral dose is absorbed,
with a peak plasma concentration occurring after 0.5 to
3 hours; inhibition of gastric secretion is present for up
to 10 hours.The elimination half-life is 1 to 2 hours, and
more than 90% of an oral dose is excreted in the urine.
Definition
ChEBI: A member of the class of 1,3-thiazoles having a dimethylaminomethyl substituent at position 2 and an alkylthiomethyl moiety at position 4.
Allgemeine Beschreibung
Nizatidine, N-[2-[[[2-(dimethylamino)methyl]-4-thiazolyl]methyl]thio]-ethyl]-N'-methyl-2-nitro-1,1-ethenediamine (Axid), is an off-white to buff crystallinesolid that is soluble in water, alcohol, and chloroform. It isa thaizole derivative of raniditine and has pKas of 2.1 (side chain) and 6.8 (dimethylamino). Nizatidine’s mechanism ofaction is similar to other H
2-antagonists, as is its receptor selectivity.It is more potent than cimetidine.
Nizatidine has excellent oral bioavailability (＞90%).The effects of antacids or food on its bioavailability arenot clinically significant. The elimination half-life is 1 to2 hours. It is excreted primarily in the urine (90%) andmostly as unchanged drug (60%). Metabolites include nizatidinesulfoxide (6%), N-desmethylnizatidine (7%), andnizatidine N-oxide (dimethylaminomethyl function).Nizatidine has no demonstrable antiandrogenic action, effectson other hormones, or inhibitory effects on cytochromeisozymes involved in the metabolism of other drugs.
Nizatidine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
