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Cyclooctapentylose Produkt Beschreibung

Cyclooctapentylose Struktur
17465-86-0
CAS-Nr.
17465-86-0
Bezeichnung:
Cyclooctapentylose
Englisch Name:
Cyclooctapentylose
Synonyma:
schardinger;Cavasol? W8;Cavamax? W8;CYCLOOCTAOSE;Cavamax(R) W8;CYCLOFLO(TM) 42;CYCLOOCTAAMYLOSE;CYCLOMALTOOCTAOSE;Resistant Dextrin;cyclooctapentylose
CBNumber:
CB9750405
Summenformel:
C48H80O40
Molgewicht:
1297.12
MOL-Datei:
17465-86-0.mol

Cyclooctapentylose Eigenschaften

Schmelzpunkt:
≥300 °C
Siedepunkt:
845.2°C (rough estimate)
alpha 
[α]D25 +174~+179° (c=1, H2O) (After Drying)
Dichte
1.2064 (rough estimate)
Brechungsindex
1.7500 (estimate)
Flammpunkt:
450℃
Löslichkeit
1 M NaOH: 25 mg/mL, may be clear to slightly hazy
Aggregatzustand
powder
Farbe
white
Optische Aktivität
[α]/D 174.0 to 180.0°
maximale Wellenlänge (λmax)
λ: 420 nm Amax: ≤0.20
Merck 
14,2718
BRN 
5725162
EPA chemische Informationen
.gamma.-Cyclodextrin(17465-86-0)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-36-24/25-22
WGK Germany  2
RTECS-Nr. GU2293080
3
HS Code  29400000

Cyclooctapentylose Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.

Chemische Eigenschaften

White powder or crystal

Chemische Eigenschaften

Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.

Vorbereitung Methode

Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.

Pharmazeutische Anwendungen

Cyclodextrins are ‘bucketlike’ or ‘conelike’ toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex.
Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability.
Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material. γ-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules;it has low toxicity and enhanced water solubility.
In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent.
In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as corticosteroids. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation.
Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.

Sicherheit(Safety)

Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations.
Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity.
Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries.
Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic.
γ-Cyclodextrin
LD50 (rat, IP): 4.6 g/kg
LD50 (rat ,IV): 4.0 g/kg
LD50 (rat, oral): 8.0 g/kg

Lager

Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.

Regulatory Status

Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections).
Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.

Cyclooctapentylose Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cyclooctapentylose Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 220)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24192 60
Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 210 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1017 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816 whatsapp +8618034554576
86-0311-83975816 grace@hbhuanhao.com CHINA 696 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23967 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8260 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 915 58

17465-86-0(Cyclooctapentylose)Verwandte Suche:


  • SCHARDINGER GAMMA-DEXTRIN
  • CYCLOFLO(TM) 42
  • CYCLOOCTAOSE
  • CYCLOOCTAAMYLOSE
  • CYCLOMALTOOCTAOSE
  • GAMMA-CYCLODEXTRIN
  • cyclooctapentylose
  • gamma-Cyclodextrin Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, 98.0-102.0% cyclodextrin basis
  • Sugammadex Impurity 17
  • Sugammadex Impurity 1 (Cyclooctapentylose)
  • Resistant Dextrin
  • GAMMA-CYCLODEXTRIN CELL CULTURE TESTED
  • schardinger
  • GAMMA-CYCLODEXTRIN, MIN 90%
  • Cyclomaltooctaose, Cyclooctaamylose, Schardinger γ-Dextrin
  • γ-CD:Cyclooctaamylose
  • ^y-Cyclodextrin hydrate
  • Gamma Cyclodextrin (200 mg)
  • Cavamax(R) W8
  • Schardinger gamma-Dextrin Cyclooctaamylose
  • Alpha and gaMMa Cyclodextrin
  • g-Cyclodextrin hydrate
  • g-Cyclodextrin standard
  • Methyl g-cyclodextrin
  • gaMMa-Cyclodextrin >=98%
  • Cavasol? W8
  • Cavamax? W8
  • gamma-Cyclodextrin produced by Wacker Chemie AG, Burghausen, Germany, >=90.0% cyclodextrin basis (HPLC)
  • 17465-86-0
  • C48H80O40
  • C6H10O58
  • Macrocycles for Host-Guest Chemistry
  • Cyclodextrins
  • Sugars
  • Oligosaccharides
  • Signal Transduction Research Tools
  • Synthetic Reagents
  • BioChemical
  • Chelation/Complexation Compounds
  • Cell Signaling and Neuroscience
  • Cell Biology
  • -
  • Biochemistry
  • Cyclodextrins
  • Functional Materials
  • Macrocycles for Host-Guest Chemistry
  • Oligosaccharides
  • Sugars
  • Dextrins、Sugar & Carbohydrates
  • Alcohols
  • Building Blocks
  • C11 to C30+
  • C20 to C60+
  • Chemical Synthesis
  • Ethers
  • Organic Building Blocks
  • Oxygen Compounds
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