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BEPOTASTINE BESILATE Produkt Beschreibung

BEPOTASTINE BESILATE Struktur
190786-44-8
CAS-Nr.
190786-44-8
Englisch Name:
BEPOTASTINE BESILATE
Synonyma:
BB;Talion;Bepreve;TAU 284;Talion (TN);BEPOTASTINE BESILATE;Bepotastine Beslilat;Bepotastine Besylate;Bepotastine Beslilate;Benzenesulfonate salt
CBNumber:
CB9810068
Summenformel:
C27H31ClN2O6S
Molgewicht:
547.07
MOL-Datei:
190786-44-8.mol

BEPOTASTINE BESILATE Eigenschaften

Schmelzpunkt:
161-163°
alpha 
D20 +6.0° (c = 5 in methanol)
storage temp. 
-196°C

Sicherheit

BEPOTASTINE BESILATE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Betotastine was introduced in Japan for the treatment of allergic rhinitis. This structurally-related derivative of chlorpheniramine and ebastine is prepared by condensation of optically-resolved 4-[1-(4-chlorophenyl)-1-(2-pyridyl)-methoxy]piperidine with ethyl 4-bromobutyrate followed by ester hydrolysis. Betotastine is the seventh marketed non-sedating histamine H1 antagonist. Its very low sedative side effect is due to very poor penetration in the central nervous system. Besides its potent and long-acting activity in models of allergic rhinitis, betotastine was also shown to act as a PAF antagonist and inhibit LTD4 in tracheal smooth muscle and ileum, IL-5 production by human peripheral blood mononuclear cells as well as eosinophil infiltration in the airway and peripheral blood. As a consequence, it is currently being developed against other allergic and respiratory disorders.

Chemische Eigenschaften

Off-White to Light Beige Solid

Originator

UBE (Japan)

Verwenden

Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7

Verwenden

Bepotastine is a histamine H1 receptor anatagonist. Bepotastine suppresses some allergic inflammatory processes such as allergic rhinitis, chronic urticaria or pruritus associated with skin conditions (eczema/dermatitis, prurigo or pruritus cutaneus).

Definition

ChEBI: An organosulfonate salt obtained by combining equimolar amounts of bepotastine and benzenesulfonic acid. A topical, selective and non-sedating histamine (H1) receptor antagonist used for treatment of itching associated with allergic co junctivitis.

Trademarks

Talion

BEPOTASTINE BESILATE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


BEPOTASTINE BESILATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 154)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 547 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21726 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23976 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58

190786-44-8()Verwandte Suche:


  • bepotastine benzenesulfonate salt
  • (S)-4-[4-(4-Chlorophenyl-2-pyridylMethoxy)piperidinyl]butyric Acid Benzenesulfonate
  • 4-[(S)-(4-Chlorophenyl)-2-pyridinylMethoxy]-1-piperidinebutanoic Acid Benzenesulfonate
  • BB
  • Bepotastine Benzenesulfonate
  • Bepreve
  • Talion
  • TAU 284
  • Bepotastine Beslilate
  • 4-[4-[(4-chlorophenyl)-pyridin-2-ylMethoxy]piperidin-1-yl]butanoic acid benzenesulfonate
  • 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, benzenesulfonate (1:1)
  • Benzenesulfonate salt
  • BEPOTASTINE BESILATE
  • 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (S)-, monobenzenesulfonate
  • 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, monobenzenesulfonate
  • 4-[4-[(R)-(4-chlorophenyl)-pyridin-2-yl-methoxy]-1-piperidyl]butanoic acid
  • (+)-(S)-4-[4-[1-(4-Chlorophenyl)-1-(2-pyridyl)methoxy]piperidin-1-yl]butyric acid benzenesulfonate
  • (+)-(S)-4-(4-((4-Chlorophenyl)(2-pyridyl)methoxy)piperidino)butyric acid monobenzenesulfonate
  • 4-((4-Chlorophenyl)-2-pyridinylmethoxy)- (S)-1-piperidinebutanoic acid monobenzenesulfonate
  • Talion (TN)
  • Bepotastine Beslilat
  • Bepotastine Besylate
  • 190786-44-8
  • C27H31ClN2O6S
  • C21H25ClN2O3C6H6O3S
  • Aromatics
  • Drug Analogues
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Other APIs
  • Inhibitors
  • API
  • Amino Acids & Derivatives
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