ChemicalBook
Chinese english Germany Japanese Korea

4-Pyridinamin Produkt Beschreibung

4-Aminopyridine Struktur
504-24-5
CAS-Nr.
504-24-5
Bezeichnung:
4-Pyridinamin
Englisch Name:
4-Aminopyridine
Synonyma:
4APY;4-AP;mi-w-3;AMpyra;EL 970;avitrol;vmi10-3;Neurelan;Prc 1237;VMI 10-3
CBNumber:
CB9853687
Summenformel:
C5H6N2
Molgewicht:
94.11
MOL-Datei:
504-24-5.mol

4-Pyridinamin Eigenschaften

Schmelzpunkt:
157 °C
Siedepunkt:
273 °C(lit.)
Dichte
1.26
Brechungsindex
1.5560 (estimate)
Flammpunkt:
156°C
storage temp. 
0-6°C
Löslichkeit
H2O: soluble50mg/mL, clear, colorless
pka
9.114(at 25℃)
Aggregatzustand
Crystalline Powder, Solid or Crystals
Farbe
White to faint grey to light yellow
Wasserlöslichkeit
Soluble in water(112 g/L at 20 deg C). Soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. Soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.
Merck 
14,3933
BRN 
105782
InChIKey
NUKYPUAOHBNCPY-UHFFFAOYSA-N
CAS Datenbank
504-24-5(CAS DataBase Reference)
NIST chemische Informationen
4-Pyridinamine(504-24-5)
EPA chemische Informationen
4-Aminopyridine (504-24-5)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T+,N,T,Xi
R-Sätze: 28-36/37/38-51/53-23/24/25
S-Sätze: 26-36/37/39-45-60-61-37/39-28A-1
RIDADR  UN 2671 6.1/PG 2
WGK Germany  3
RTECS-Nr. US1750000
8-21
Selbstentzündungstemperatur 640 °C
Hazard Note  Toxic/Irritant
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29333999
Giftige Stoffe Daten 504-24-5(Hazardous Substances Data)
Toxizität LD50 orally in Rabbit: 21 mg/kg
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H311 Giftig bei Hautkontakt. Akute Toxizität dermal Kategorie 3 Achtung P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
H372 Schädigt bei Hautkontakt und Verschlucken die Organe bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 1 Achtung P260, P264, P270, P314, P501
H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 2
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P307+P311 BEI Exposition: GIFTINFORMATIONSZENTRUM oder Arzt anrufen.

4-Pyridinamin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R28:Sehr giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S1:Unter Verschluss aufbewahren.

Beschreibung

Dalfampridine (also referred to as 4-AP) is the first drug approved by the FDA to improve walking in patients with multiple sclerosis (MS). Dalfampridine is a voltage-gated potassium channel blocker that readily penetrates the CNS and increases the conduction and duration of action potential across nerve fibers resulting in enhanced functionality as observed in the walking speed of MS patients.
From a safety perspective, seizure was the most important adverse event from various dalfampridine clinical trials. Therefore, dalfampridine is contraindicated in patients with a history of seizures. Since dalfampridine is primarily excreted by the kidney as unchanged drug, it is also contraindicated in patients with moderate to severe renal impairment. Assessing the overall benefit–risk profile from various clinical trials, the FDA approved dalfampridine (daily oral dose of 10 mg, b.i.d.) to improve walking in MS patients with existing gait impairment.

Chemische Eigenschaften

WHITE TO SLIGHTLY YELLOW FINE CRYSTALLINE POWDER

Chemische Eigenschaften

4-aminopyridine is a white crystalline solid that contains about 98% active ingredient. It is soluble in water and slightly soluble in benzene and ether. 4-Aminopyridine formulations are classifi ed by the US Environmental Protection Agency (US EPA) as restricted use pesticides (RUPs) and therefore should be purchased and used only by certifi ed and trained workers and applicators. Avitrol is available as grain baits or as a powder concentrate. It is one of the most prominent avicides. It is registered with the EPA for use against red-winged blackbirds, blackbirds in agricultural fi elds, grackles, pigeons, and sparrows around public buildings, and various birds around livestock feeding pens. Avitrol repels birds by poisoning a few members of a fl ock, causing them to become hyperactive.

Chemische Eigenschaften

4-Aminopyridine is white to tan or brown crystalline material. Odorless.

Originator

Rush University Medical Center (United States)

Verwenden

vasodilator

Verwenden

Dalfampridine is used in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. Dalfampridine is a precursor to the drug Pinacidil.

Definition

ChEBI: An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.

Trademarks

Neurelan (E′lan);Ampyra.

Allgemeine Beschreibung

White crystalline material with no odor. Used as an avicide, an intermediate and as a fixer for some textile dyes.

Reaktivität anzeigen

4-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

Material may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Material affects neural transmission. In sufficient concentrations, material may cause metabolic acidosis, respiratory arrest, and cardiac arrhythmias.

Health Hazard

4-Aminopyridine, a pyridine compound, is an extremely effective bird poison. In agriculture, 4-AP is used as an extremely effective bird poison sold under the brand name Avitrol. It is highly toxic to all mammals including humans if dosages are exceeded, and as an experimental drug, the recommended dose data is unavailable. 4-Aminopyridine blocks

Brandgefahr

Material may produce irritating or poisonous gases in fire. Runoff from fire control water may give off irritating or poisonous gases.

Sicherheitsprofil

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations and vomiting. When heated to decomposition it emits toxic fumes of NOx,.

mögliche Exposition

Used as a chemical intermediate in pharmaceuticals; as an agricultural chemical for field crops; and as a bird repellent and poison

Versand/Shipping

UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

läuterung methode

Crystallise the aminopyridine from *benzene/EtOH, then recrystallise it twice from water, then crush and dry it for 4hours at 105o [Bates & Hetzer J Res Nat Bur Stand 64A 427 1960]. It has also been crystallised from EtOH, *benzene, *benzene/pet ether, toluene and sublimes in a vacuum. [Beilstein 22/9 V 106.]

Inkompatibilitäten

Sodium nitrite, strong oxidizers. Avoid contact with acid anhydrides, acid chlorides; and strong acids.

Waste disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposalIncineration with nitrogen oxides removal from effluent gas.

4-Pyridinamin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


4-Pyridinamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 401)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Hangzhou Cyanochem Co., Ltd.
+86 17788583750
+86 571 85220831 sales@cyanochem.com CHINA 284 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21806 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24697 60
Zjartschem
+86-571-8723 8903 jocelynpan@zjarts.com
+86-571-87063838 jocelynpan@zjarts.com CHINA 997 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30052 58
NINGBO INNO PHARMCHEM CO., LTD.
13867897135
sales@nbinno.com CHINA 925 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23979 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28235 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
whatsapp: +8619930501651 breeduan@crovellbio.com CHINA 2404 58

504-24-5(4-Pyridinamin)Verwandte Suche:


  • 4-amino-pyridin
  • Avitrol 200
  • avitrol200
  • Compound 1861
  • Frampridine
  • mi-w-3
  • 4-AP
  • 4APY
  • 4-pyridinamine
  • 4-PYRIDYLAMINE
  • Amino-4-pyridine
  • AMINOPYRIDINE, 4-
  • AKOS 91150
  • FAMPRIDINE
  • GAMMA-AMINOPYRIDINE
  • GAMMA-PYRIDYLAMINE
  • avitrol
  • AVITROL(R)
  • AURORA KA-676
  • TIMTEC-BB SBB004393
  • γ-Pyridylamine
  • PYRIDIN-4-YLAMINE
  • PYRIDIN-4-AMINE
  • P-AMINO PYRIDINE
  • 4-Aminopyridine;4-AP; Pyridin-4-amine
  • 4-PyridinylaMine
  • AMpyra
  • DalfaMpridine
  • EL 970
  • Neurelan
  • Phillips 1861
  • phillips1861
  • Pimadin (free base)
  • Prc 1237
  • Pyridine, 4-amino-
  • pyridine,4-amino-
  • pyridine,4-amino-0
  • pyridine,4-amino-000
  • Rcra waste number P008
  • VMI 10-3
  • vmi10-3
  • p-Amino Pyridine 4-Amino Pyridine
  • 4-Aminopyridine (RTC is agent for this item in Europe)
  • 4-AMINOPYRIDINE PESTANAL
  • 4-AMINOPYRIDINE INDUCES DEPOLARIZATIO
  • 4-AMINOPYRIDINE, 99+%
  • 4-AMINO PYRIDINE FOR SYNTHESIS
  • 4-Aminopyridine,98%
  • 4-AMINOPYRIDINE,REAGENT
  • AMINOPYRIDINE, 4-(P)
  • PARA-AMINOPYRIDINE
  • 4-AMINO PYRIDINE PYRIDIN-4-YLAMINE
  • 4-Pyridinamine, 4-Pyridylamine, Fampridine
  • 4-Aminopyridine4-AP
  • NSC 15041
  • Pyridine-4-ylaMine
  • faMpridine-SR
  • DalfaMpridine (4-AMinopyridine)
Copyright 2019 © ChemicalBook. All rights reserved