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Methylglyoxal Dimethyl Acetal

Methylglyoxal Dimethyl Acetal Structure
Methylglyoxal Dimethyl Acetal structure
CAS No.
6342-56-9
Chemical Name:
Methylglyoxal Dimethyl Acetal
Synonyms
1,1-Dimethoxypropan-2-one;1,1-DIMETHOXYACETONE;PYRUVIC ALDEHYDE DIMETHYL ACETAL;2,2-DiMethoxypropanal;2-Propanone, 1,1-dimethoxy-;Pyruvic aL;Pyruvaldehyde 1;1,1-Dimethoxyaceton;Methylglyoxal 1,1-di;1,1-Dimethoxypropanone
CBNumber:
CB00123163
Molecular Formula:
C5H10O3
Molecular Weight:
118.13
MDL Number:
MFCD00008758
MOL File:
6342-56-9.mol
MSDS File:
SDS
Last updated:2026-01-13 11:14:14
Product description Number Pack Size Price
Methylglyoxal 1,1-dimethyl acetal ≥97% 170216 100ml $94.4
Methylglyoxal 1,1-dimethyl acetal ≥97% 170216 500ml $179
Pyruvic Aldehyde Dimethyl Acetal >97.0%(GC) P1264 25mL $75
Pyruvic Aldehyde Dimethyl Acetal >97.0%(GC) P1264 100mL $154
Pyruvic Aldehyde Dimethyl Acetal >97.0%(GC) P1264 500mL $371
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Methylglyoxal Dimethyl Acetal Properties

Melting point -57 °C
Boiling point 143-147 °C(lit.)
Density 0.976 g/mL at 25 °C(lit.)
vapor pressure 11hPa at 20℃
refractive index n20/D 1.398(lit.)
Flash point 100 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form Liquid
color Clear colorless to yellow
Water Solubility MISCIBLE
BRN 1560557
InChI 1S/C5H10O3/c1-4(6)5(7-2)8-3/h5H,1-3H3
InChIKey ULVSHNOGEVXRDR-UHFFFAOYSA-N
SMILES COC(OC)C(C)=O
LogP -0.199 (est)
CAS DataBase Reference 6342-56-9
FDA UNII 3772KY264D
NIST Chemistry Reference 2-Propanone, 1,1-dimethoxy-(6342-56-9)
EPA Substance Registry System 2-Propanone, 1,1-dimethoxy- (6342-56-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H315-H319
Precautionary statements  P210-P302+P352-P305+P351+P338
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  10-36/38
Safety Statements  26-36-16
RIDADR  UN 1224 3/PG 3
WGK Germany  1
TSCA  TSCA listed
HazardClass  3
PackingGroup  III
HS Code  29145000
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

Methylglyoxal Dimethyl Acetal price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 170216 Methylglyoxal 1,1-dimethyl acetal ≥97% 6342-56-9 100ml $94.4 2025-07-31 Buy
Sigma-Aldrich 170216 Methylglyoxal 1,1-dimethyl acetal ≥97% 6342-56-9 500ml $179 2025-07-31 Buy
TCI Chemical P1264 Pyruvic Aldehyde Dimethyl Acetal >97.0%(GC) 6342-56-9 25mL $75 2025-07-31 Buy
TCI Chemical P1264 Pyruvic Aldehyde Dimethyl Acetal >97.0%(GC) 6342-56-9 100mL $154 2025-07-31 Buy
TCI Chemical P1264 Pyruvic Aldehyde Dimethyl Acetal >97.0%(GC) 6342-56-9 500mL $371 2025-07-31 Buy
Product number Packaging Price Buy
170216 100ml $94.4 Buy
170216 500ml $179 Buy
P1264 25mL $75 Buy
P1264 100mL $154 Buy
P1264 500mL $371 Buy

Methylglyoxal Dimethyl Acetal Chemical Properties,Uses,Production

Chemical Properties

clear colorless to yellow liquid

Uses

Methylglyoxal 1,1-dimethyl acetal was used in the synthesis of methylglyoxal via hydrolysis in the presence of H2SO4. It was used to investigate the effects of methylglyoxal-mediated glycation on the structure, thermal stability and enzyme activity of yeast enolase in vivo.

Uses

Pyruvic Aldehyde Dimethyl Acetal is used in the preparation of MCL1 inhibitors S63845 which is tolerable and effective in diverse cancer models. Also, acts as a synthetic reagent for the preparation of 8novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. Selective inhibition of neuronal nitric oxide synthase is an important therapeutic approach to target neurodegenerative disorders.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 2642, 1976 DOI: 10.1021/jo00877a030

Synthesis

It is produced in two main stages. Stage 1: Preparation of acetone aldehyde monohydrate. 1,2-Propanediol undergoes gas-phase oxidation over a modified electrolytic silver catalyst. Optimal conditions: temperature 350-650??C, oxygen/alcohol ratio 1.1-1.2, space velocity 18,000-20,000 h?1. Conversion is 100%, methylglyoxal selectivity is 76%. Stage 2: Preparation of Methylglyoxal 1,1-dimethyl acetal. acetone aldehyde monohydrate reacts with methanol under reflux catalyzed by a modified resin. Distillation removes low-boilers and methanol. Steam distillation gives a crude solution. Dichloromethane extraction and rectification yield the pure product.

Methylglyoxal Dimethyl Acetal Preparation Products And Raw materials

Raw materials

Methylglyoxal

Preparation Products

4-DIMETHOXYMETHYL-6-HYDROXYPYRIMIDINE-2-THIOL 3-Methylisoquinoline 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE 1H-Imidazole-1-carboxylic acid, 2-amino-4-(dimethoxymethyl)-,1,1-dimethylethyl ester 4-(Dimethoxymethyl)-2-(methylsulfonyl)pyrimidine
ethyl 5,5-dimethoxy-2,4-dioxopentanoate

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Methylglyoxal Dimethyl Acetal Suppliers

Global( 374)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8754 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21600 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +8618949832763 info@tnjchem.com China 2988 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29837 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2950 58
HubeiwidelychemicaltechnologyCo.,Ltd 		18627774460 faith@widelychemical.com CHINA 742 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Hefei TNJ Chemical Industry Co.,Ltd. 		55
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Jinan Finer Chemical Co., Ltd 		58
HubeiwidelychemicaltechnologyCo.,Ltd 		58
Hubei xin bonus chemical co. LTD 		58

View Lastest Price from Methylglyoxal Dimethyl Acetal manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methylglyoxal 1,1-dimethyl acetal pictures 2024-05-09 Methylglyoxal 1,1-dimethyl acetal
6342-56-9
 US $350.00 / Kg 1Kg 98 500 Kg R&D Scientific Inc.
Methylglyoxal 1,1-dimethyl acetal pictures 2021-08-12 Methylglyoxal 1,1-dimethyl acetal
6342-56-9
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Methylglyoxal 1,1-dimethyl acetal Spectrum

Methylglyoxal 1,1-dimethyl acetal(6342-56-9)MSMethylglyoxal 1,1-dimethyl acetal(6342-56-9)1HNMRMethylglyoxal 1,1-dimethyl acetal(6342-56-9)13CNMRMethylglyoxal 1,1-dimethyl acetal(6342-56-9)IR1Methylglyoxal 1,1-dimethyl acetal(6342-56-9)Raman

6342-56-9(Methylglyoxal Dimethyl Acetal)Related Search:

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Methoxyacetone 4-Methoxyphenylacetone Benzhydrol 2,2-Dimethoxypropane 1,1,2-Trimethoxyethane
N,N-Dimethylformamide Acetal Dimethyl fumarate Methylglyoxal Dimethyl Acetal

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PYRUVALDEHYDE DIMETHYLACETAL PYRUVALDEHYDE 1,1-DIMETHYL ACETAL PYRUVALDEHYDE-1-DIMETHYL ACETAL Methylglyoxal dimethyl acetal~Pyruvaldehyde dimethyl acetal PYRUVIC ALDEHYDE DIMETHYL ACETAL, 97+% PYRUVIC ALDEHYDE DIMETHYL ACETAL 98% PYRUVIC ALDEHYDE DIMETHYL ACETAL(INTERMEDIATE OF B-CAROTENE) 2-Propanone, 1,1-dimethoxy- (9CI) PYRUVICALDEHYDEDIETHYLACETAL 1,1-Dimethoxyaceton Pyruvic aldehyde dimethyl aecetal 1,1-Dimethoxypropane-2-one 2-Oxopropanal dimethyl acetal Pyruvic aldehyde dimethyl acetal,98% 1,1-Dimethoxypropanone 1,1-Dimethoxyacetone, Pyruvaldehyde-1-dimethyl acetal, Pyruvic aldehyde dimethyl acetal Methylglyoxal 1,1-di Acetone, Methanol aldolase two 1,1-Dimethoxypropan-2-one, Methylglyoxal dimethyl acetal, Pyruvaldehyde dimethyl acetal 1,1-Dimethoxyaceton (Methylglyoxaldimethylacetal) 1,1-Dimethoxyacetone 1,1-Dimethoxy-2-propanone Methylglyoxal Dimethyl Acetal Methylglyoxal 1,1-diMethyl acetal >=97% 1,1-DIMETHOXY-2-PROPANONE Methylglyoxal 1,1-dimethyl aceta ACETYLFORMALDEHYDE DIMETHYL ACETAL ALPHA,ALPHA-DIMETHOXYACETONE METHYLGLYOXAL 1, 1-DIMETHYL ACETAL METHYLGLYOXAL DIMETHYL ACETAL 1,1-dimethoxy-2-propanon Dimethoxymethyl methyl ketone Acetone aldehyde condensation of Methanol Pyruvic aL Pyruvaldehyde dimethyl acetal estimate PyruvicAldehydeDimethylAcetal> Methylglyoxaldimethyl acetal (Pyruvicaldehyde dimethylacetal) PYRUVIC ALDEHYDE DIMETHYL ACETAL 1,1-Dimethoxypropan-2-one 2-Propanone, 1,1-dimethoxy- 2,2-DiMethoxypropanal 1,1-DIMETHOXYACETONE Pyruvaldehyde 1 Pyruvaldehyde dimethyl acetal English name: Pyruvic aldehyde dimethyl acetal Methylglyoxal Dimethyl Acetal [MGDA] Acetone aldehyde dimethyl acetal 6342-56-9 6342-59-9 CH3COCHOCH32 Organic Building Blocks Oxygen Compounds Acetals/Ketals/Ortho Esters Building Blocks ACETYLGROUP Aldehydes blocks BuildingBlocks ketone (intermediate of -carotene)