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Phenethylamine

CAS No.
64-04-0
Chemical Name:
Phenethylamine
Synonyms
Phenylethylamine;PHENETHYLAMINE;BENZENEETHANAMINE;2-Phenylethanamine;2-PHENETHYLAMINE;BETA-PHENYLETHYLAMINE;β-phenylethylamine;FEMA 3220;Phenethylamine, 99.5%;beta-Phenylaethylamin
CBNumber:
CB00126130
Molecular Formula:
C8H11N
Molecular Weight:
121.18
MDL Number:
MFCD00008184
MOL File:
64-04-0.mol
Last updated:2023-05-25 18:00:57

Phenethylamine Properties

Melting point -60 °C
Boiling point 197-200 °C (lit.)
Density 0.962 g/mL at 20 °C (lit.)
vapor density 4.18 (vs air)
vapor pressure 0.4 hPa (20 °C)
refractive index n20/D 1.533(lit.)
FEMA 3220 | PHENETHYLAMINE
Flash point 195 °F
storage temp. Store below +30°C.
solubility alcohol: freely soluble(lit.)
pka 9.84(at 25℃)
form liquid
color clear, colorless
PH 11.5 (4.3g/l, H2O, 20℃)
Odor fishy odor
PH Range 11.5 at 4.3 g/l at 20 °C
explosive limit 1.0-5.5%(V)
Odor Type fishy
Viscosity 2.40 mm2/s at 23 °C
Water Solubility SOLUBLE
Sensitive Air Sensitive
JECFA Number 1589
Merck 14,6026
BRN 507488
Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong acids.
InChIKey BHHGXPLMPWCGHP-UHFFFAOYSA-N
LogP 1.46
Substances Added to Food (formerly EAFUS) PHENETHYLAMINE
CAS DataBase Reference 64-04-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 327C7L2BXQ
NIST Chemistry Reference Benzeneethanamine(64-04-0)
EPA Substance Registry System Phenethylamine (64-04-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06
Signal word  Danger
Hazard statements  H290-H301-H314
Precautionary statements  P234-P270-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  C
Risk Statements  22-34
Safety Statements  26-36/37/39-45
RIDADR  UN 2922 8/PG 2
WGK Germany  1
RTECS  SG8750000
9-23
Autoignition Temperature 425 °C
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29214980
Toxicity LD50 orally in Rabbit: 300 mg/kg
NFPA 704
2
3 1

Phenethylamine Chemical Properties,Uses,Production

Chemical Properties

Phenethylamine has a fish odor.

Chemical Properties

colourless or slightly yellow liquid with

Occurrence

Reported found in the oil of bitter almonds. Also found in grapes, cabbage, kale, carrots, blue and provolone cheese, fatty fish, beer, sherry, grape wines, cocoa, cauliflower, beetroot, radish, rhubarb, sake and dried bonito.

Uses

Phenethylamine is used in manufacturing anti-depression agents and anti diabetic drugs. It is also used as the goodds for drug jiangtangling intermediate, also used for other organic synthesis.

Definition

ChEBI: A phenylethylamine having the phenyl substituent at the 2-position.

Preparation

By reduction of benzyl cyanide with sodium metal in alcohol or with Raney-Ni.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 34, p. 3905, 1986 DOI: 10.1248/cpb.34.3905
Journal of the American Chemical Society, 94, p. 6561, 1972 DOI: 10.1021/ja00773a060
Tetrahedron Letters, 21, p. 1719, 1980 DOI: 10.1016/S0040-4039(00)77819-1

General Description

Phenethylamine, a new stimulant designer drug, was analyzed by the liquid chromatography high-resolution mass spectrometry quadrupole-time-of-flight (LC-HRMS-QTOF) method.

Safety Profile

Poison by intraperitoneal, subcutaneous, intracervical, and intravenous routes. Moderately toxic by ingestion. A strong base. A skin irritant and possible sensitizer. When heated to decomposition it emits toxic fumes of NOx. See also AMINES

Purification Methods

Distil the amine from CaH2, under reduced pressure, just before use. [Beilstein 12 H 1096, 12 IV 2453.]

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