Loperamide Hcl | 34552-83-5

Loperamide Hcl Properties

Melting point	223-225°C
Density	1.1905 (rough estimate)
refractive index	1.6100 (estimate)
storage temp.	2-8°C
solubility	Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol.
pka	8.66(at 25℃)
color	White to Almost white
Merck	14,5571
CAS DataBase Reference	34552-83-5(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	Imodium; loperamide hydrochloride
FDA UNII	77TI35393C
NCI Drug Dictionary	Imodium A-D

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2811 6.1/PG 3

WGK Germany

3

RTECS

TM4960000

HazardClass

6.1(b)

PackingGroup

III

HS Code

29333990

Toxicity

LD50 in mice (mg/kg): 75 s.c.; 28 i.p.; 105 orally; in rats (mg/kg): 185 orally (Niemegeers)

NFPA 704

	0
2		0

Loperamide Hcl price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	5.08162	Loperamide Hydrochloride - CAS 34552-83-5 - Calbiochem	34552-83-5	1g	$154	2024-03-01	Buy
Sigma-Aldrich	34014	Loperamide hydrochloride VETRANAL?, analytical standard	34552-83-5	100mg	$57.4	2024-03-01	Buy
Sigma-Aldrich	1370000	Loperamide hydrochloride United States Pharmacopeia (USP) Reference Standard	34552-83-5	200mg	$436	2024-03-01	Buy
Sigma-Aldrich	BP635	Loperamide hydrochloride British Pharmacopoeia (BP) Reference Standard	34552-83-5	100MG	$259	2023-06-20	Buy
TCI Chemical	L0154	Loperamide Hydrochloride >98.0%(T)(HPLC)	34552-83-5	5g	$98	2024-03-01	Buy

Product number	Packaging	Price	Buy
5.08162	1g	$154	Buy
34014	100mg	$57.4	Buy
1370000	200mg	$436	Buy
BP635	100MG	$259	Buy
L0154	5g	$98	Buy

Loperamide Hcl Chemical Properties,Uses,Production

Description

loperamide Hcl is an antidiarrheal used to treat diarrhea. It is also used to reduce the amount of stool in people who have an ileostomy (re-routing of the bowel through a surgical opening in the stomach). loperamide Hcl is available in generic form and over-the-counter.

Uses

Loperamide Hcl is used to treat sudden diarrhea (including traveler's diarrhea). It works by slowing down the movement of the gut. This decreases the number of bowel movements and makes the stool less watery. Loperamide is also used to reduce the amount of discharge in patients who have undergone an ileostomy. It is also used to treat on-going diarrhea in people with inflammatory bowel disease.Loperamide treats only the symptoms, not the cause of the diarrhea (such as infection).

Brand name

Imodium (Janssen); Imodium (McNeil).

Biological Activity

High affinity μ -opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for μ -, δ - and κ -opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca²⁺ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca²⁺ channels and at higher concentrations it reduces Ca²⁺ flux through NMDA receptor operated channels.

Pharmacology

Loperamide Hcl protects against diarrhea longer than does diphenoxylate. It reduces the daily fecal volume and decreases intestinal fluid and electrolyte loss. Loperamide Hcl produces rapid and sustained inhibition of the peristaltic reflex through depression of longitudinal and circular muscle activity.The drug also possesses antisecretory activity, presumably through an effect on intestinal opioid receptors.

Side effects

Loperamide Hcl may cause serious side effects including:

diarrhea that is watery or bloody,

stomach pain or bloating,

ongoing or worsening diarrhea,

fast or pounding heartbeats,

fluttering in your chest,

shortness of breath, and

lightheadedness

Loperamide Hcl synthesis

Synthesis of Loperamide Hcl from 4-(4-Chlorophenyl)piperidin-4-ol and 3,3-Diphenyltetrahydrofuran-2-ylidene(dimethyl)ammonium bromide

Loperamide Hcl Preparation Products And Raw materials

Raw materials

Thionyl chloride Dimethylamine Hydrochloric acid Hydrogen bromide 4-(4-Chlorophenyl)piperidin-4-ol

Preparation Products

Loperamide Hcl Suppliers

Global( 554)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Zhanyao Biotechnology Co. Ltd	15369953316 +8615369953316	admin@zhanyaobio.com	China	2136	58
APOLLO HEALTHCARE RESOURCES	+6596580999	sales@apollo-healthcare.com.sg	Singapore	400	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Shandong Huisheng Import & Export Co., Ltd.	+86-13176845580 +86-13176845580	da@zhongda-biotech.com	China	248	58
Anhui Zhongda Biotechnology Co., Ltd	+8619956560829	justine@zhongda-biotech.com	China	300	58
Anhui Zhongda Biotechnology Co., Ltd	+8615689548120	linda@zhongda-biotech.com	China	204	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	655	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

Supplier	Advantage
Hebei Zhanyao Biotechnology Co. Ltd	58
APOLLO HEALTHCARE RESOURCES	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Shandong Huisheng Import & Export Co., Ltd.	58
Anhui Zhongda Biotechnology Co., Ltd	58
Anhui Zhongda Biotechnology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from Loperamide Hcl manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-02-25	Loperamide HCl 34552-83-5	US $100.00 / KG	1KG	99	5tons	Shanxi Naipu Import and Export Co.,Ltd
2021-07-20	Loperamide 53179-11-6	US $1.00-1.00 / KG	1g	99%	50tons	Shaanxi Dideu Medichem Co. Ltd
2020-12-11	Loperamide HCl 34552-83-5	US $100.00 / KG	10KG	99%	10	Hebei Henghe Import and Export Trading Co. LTD

Loperamide HCl
34552-83-5
US $100.00 / KG
99
Shanxi Naipu Import and Export Co.,Ltd

Loperamide
53179-11-6
US $1.00-1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

Loperamide HCl
34552-83-5
US $100.00 / KG
99%
Hebei Henghe Import and Export Trading Co. LTD

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blox butyramidehcl dissenten fortasec imosec LABOTEST-BB LT00134703 LOSERAMIN LOPERAMIDE HYDROCHLORIDE 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINBUTYRAMIDE HYDROCHLORIDE 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINEBUTANAMIDE HYDROCHLORIDE 4-(4-chlorophenyl)-4-hydroxy-n,n-dimethyl-alpha,alpha-diphenylpiperidine-1-butyramide monohydrochloride 4-[P-CHLOROPHENYL]-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINEBUTYRAMIDE HYDROCHLORIDE 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidinebutanamide Hydrochloride Arret. B Imosse px. Brel. Dossemten 4-(4-Chlorophenyl)-4-hydroxy-N,N-(dimethyl-d6)-a,a-diphenyl-1-piperidinebutanamide Hydrochloride Fortasec-d6 Imodium-d6 Imosec-d6 Imossel-d PJ-185-d6 px. Brel. Dossemten-d6 R-18553-d6 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-.alpha.,.alpha.-diphenyl-, monohydrochloride 4-(p-chlorophenyl)-4-hydroxy-n,n-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride LOPERAMIDEHYDROCHLORIDE,USP Loperamide hydrochloride, Vetranal LOPERAMIDE HYDROCHLROIDE 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,a-diphenyl-1-piperidinebutanamide Hydrochloride Imossel lopemid lopemin loperyl pj185 r18553 4-(4-Chlorophenyl)-4-hydroxy-N,N-(dimethyl-d6)-α,a-diphenyl-1-piperidinebutanamide Hydrochloride Imossel-d6 4-(4-Chlorophenyl)-N,N-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidinebutanamide hydrochloride Cagudalin Clalet Taipemin 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamidehydrochloride Loperamide Hydrochloride (200 mg) Loperamide hydrochlo LUPERAMIDE HCL 4-(4-Chlorophenyl)-4-hydroxy-N,N-(diMethyl-d6)-α,α-diphenyl-1-piperidinebutanaMide Hydrochloride Arret-d6 Blox-d6 Brek-d6 Dissenten-d6 IModiuM A-D-d6 LopeMid-d6 LopeMin-d6 Loperazine-d6 Loperyl-d6 LopodiuM-d6 Maalox Antidiarrheal-d6