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ChemicalBook >> CAS DataBase List >>Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate

Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate

Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate Structure
Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate structure
CAS No.
113028-17-4
Chemical Name:
Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate
Synonyms
PL-10;Tilorone Impurity 2;PRULIFLOXACIN INTERMEDIATE 2;Prulifloxacin InterMediate PL-1;Prulifloxacin Intermediate PL-10;Ethyl 6-fluoro-1-Methyl-4-oxo-7-(1-piprazinyl)-4H-;Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiaz...;Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-(1,3)-thiazeto(3,2-a);ETHYL 6-FLUORO-1-METHYL-4-OXO-7-(1-PIPRAZINYL)-4H-(1,3)THIAZETO(3,2-A)QUINOLINE-;thyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate
CBNumber:
CB0100236
Molecular Formula:
C18H20FN3O3S
Molecular Weight:
377.43
MDL Number:
MFCD08063938
MOL File:
113028-17-4.mol
Last updated:2025-07-24 18:13:44
Request For Quotation

Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate Properties

Melting point 224 °C
Boiling point 579.1±50.0 °C(Predicted)
Density 1.44±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 8.69±0.10(Predicted)
CAS DataBase Reference 113028-17-4(CAS DataBase Reference)

Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 094734 Ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate 113028-17-4 250.00mg $492 2026-05-18 Buy
Matrix Scientific 094734 Ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate 113028-17-4 1.00g $1092 2026-05-18 Buy
aablocks AA007RDP Ethyl 6-Fluoro-1-Methyl-4-Oxo-7-(Piperazin-1-Yl)-1,4-Dihydro-[1,3]Thiazeto[3,2-A]Quinoline-3-Carboxylate 95% 113028-17-4 250mg $11 2026-05-28 Buy
aablocks AA007RDP Ethyl 6-Fluoro-1-Methyl-4-Oxo-7-(Piperazin-1-Yl)-1,4-Dihydro-[1,3]Thiazeto[3,2-A]Quinoline-3-Carboxylate 95% 113028-17-4 1g $18 2026-05-28 Buy
Crysdot CD11349247 Ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate 95+% 113028-17-4 1g $347 2026-05-27 Buy
Product number Packaging Price Buy
094734 250.00mg $492 Buy
094734 1.00g $1092 Buy
AA007RDP 250mg $11 Buy
AA007RDP 1g $18 Buy
CD11349247 1g $347 Buy

Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate Chemical Properties,Uses,Production

Uses

Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate is an off-white to slightly yellow powder used as an intermediate for prulifloxacin.

Synthesis

Piperazine

110-85-0

Ethyl 6,7-difluoro-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate

113046-72-3

Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate

113028-17-4

The general procedure for the synthesis of ethyl 6-fluoro-7-piperazine-1-methyl-4-oxo-1,4-dihydro-[1,3]thiazepine[3,2-a]quinoline-3-carboxylate from ethyl 6,7-difluoro-1-methyl-4-oxo-1,4-dihydro-[1,3]thiazepine[3,2-a]quinoline-3-carboxylate and piperazine was carried out as follows: 50 g of ethyl 6,7-difluoro-1-methyl-4 -oxo-4H-[1,3]thiazino[3,2-a]quinoline-3-carboxylic acid ethyl ester was dissolved in 5 volumes of DMSO and heated to 60 °C. Subsequently, 40 g of piperazine was added and the reaction was kept stirred at 60°C for 4 hours. After completion of the reaction, the mixture was cooled to room temperature, 5 volumes of acetonitrile was added and stirring was continued at room temperature for 4 hours. The precipitate was collected by filtration and dried to give 52.8 g of ethyl 6-fluoro-7-piperazine-1-methyl-4-oxo-[1,3]thiazolocyclo[3,2-a]quinoline-3-carboxylate in 87% yield. After further purification, the yield of ethyl 6-fluoro-7-piperazine-1-methyl-4-oxo-[1,3]thiazolocyclo[3,2-a]quinoline-3-carboxylate was up to 99%.

References

[1] Patent: CN107383069, 2017, A. Location in patent: Paragraph 0061; 0062
[2] Patent: CN107501298, 2017, A. Location in patent: Paragraph 0055; 0056
[3] Journal of Medicinal Chemistry, 1992, vol. 35, # 25, p. 4727 - 4738
[4] Patent: US4843070, 1989, A
[5] Patent: WO2009/93268, 2009, A1. Location in patent: Page/Page column 15

Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate synthesis

110-85-0
113046-72-3
113028-17-4
Synthesis of Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate from Piperazine and Ethyl 6,7-difluoro-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate

Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate Preparation Products And Raw materials

Raw materials

Carbamodithioic acid, N-(3,4-difluorophenyl)-, compd. with N,N-diethylethanamine (1:1) 6,7-Difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylicacidethylester 113028-76-5 3,4-Difluoroaniline 113028-77-6
3,4-Difluorophenyl isothiocyanate Ethyl 6,7-difluoro-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate Piperazine

1of2

Preparation Products

Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate Suppliers

Global( 77)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Sphchem Co., Ltd. 021-56491756 13512199871 2819742715@qq.com China 3994 55
Xi'an Manareco New Materials Co., Ltd. 029-68669089-8816 market@xarlm.com China 479 55
Hubei XinyuanShun Chemical Co., Ltd. 13971561712, 13995564702, 027-50664929 hbeixys2001@163.com China 3110 55
Shanghai Meishui Chemical Technology Co., Ltd 021-60549325 18616193163 China 4518 56
HBCChem, Inc. +1-510-219-6317 sales@hbcchem.com United States 10628 60
Chengdu HuaXia Chemical Reagent Co. Ltd 400-1166-196 13458535857 cdhxsj@163.com China 13323 58
Chizhou Kailong Import and Export Trade Co., Ltd. xg01_gj@163.com China 9413 50
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Wuhai Shuou Technology Co., Ltd. 17792809151;18872220797 2355916837@ycphar.com China 6120 55
Shandong Ono Chemical Co., Ltd. 0539-6362799 20） China 9998 58
Supplier Advantage
Shanghai Sphchem Co., Ltd. 55
Xi'an Manareco New Materials Co., Ltd. 55
Hubei XinyuanShun Chemical Co., Ltd. 55
Shanghai Meishui Chemical Technology Co., Ltd 56
HBCChem, Inc. 60
Chengdu HuaXia Chemical Reagent Co. Ltd 58
Chizhou Kailong Import and Export Trade Co., Ltd. 50
Amadis Chemical Company Limited 58
Wuhai Shuou Technology Co., Ltd. 55
Shandong Ono Chemical Co., Ltd. 58

View Lastest Price from Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate pictures 2019-07-06 Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate
113028-17-4
 $200.00 100G 99% 10KG,20KG,50KG Career Henan Chemical Co

113028-17-4(Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate)Related Search:

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N-Ethylmethylamine N-Aminoethylpiperazine Kresoxim-methyl 2-Ethylhexyl ferulate Methyl salicylate
Methyl Fluorine Prulifloxacin 3-Quinolinecarboxylic acid 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
Methyl bromide Ethyl (4-dimethyllaminobenzoyl) acetate Quinoline-3-carboxylic acid ethyl ester

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6-FLUORO-1-METHYL-4-OXO-7-(1-PIPERAZINYL)-4H-(1,3)THIAZETO(3,2-A)QUINOLINE-3-CARBOYLIC ACID ETHYL ESTER 6-FLUORO-1-METHYL-4-OXO-7-(1-PIPRAZINYL)-1H,4H-(1,3)THIAZETO(3,2-A)QUINOLINE-3-CARBOXYLIC ACID, ETHYL ESTER 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-1H,4H-[1,3]-thiazeto[3,2-a]-3-quinolinecarboxylic acid ethyl ester Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-(1,3)-thiazeto(3,2-a) ETHYL 6-FLUORO-1-METHYL-4-OXO-7-(1-PIPERAZINYL)-4H-(1,3)-THIAZETO(3,2-A) QUINOLINE-3-CARBOXYLATE Prulifloxacin Intermediate PL-10 Ethyl 6-fluoro-1-Methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate 6- fluoro -1-Methyl-4- oxo-7-(1-piperazinyl)-4H-(1,3) S,N-containing heterocyclic bi-(3,2-a) quinoline -3- carboxylic acid ethyl ester Ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carb thyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate Ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-c ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4h-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate ETHYL 6-FLUORO-1-METHYL-4-OXO-7-(1-PIPRAZINYL)-4H-(1,3)THIAZETO(3,2-A)QUINOLINE- Ethyl 6-Fluoro-1-Methyl-4-Oxo-7-91-Piperazinyl)-4h-(1,3-)-Thiazeto-(3,2-A)Quinoline-3-Carboxylate Ethyl 6-fluoro-1-Methyl-4-oxo-7-(1-piprazinyl)-4H- 1,6-diMethyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazetidino[3,2-a]quinoline-3-carboxylic acid hydrofluoride 6-FLUORO-1-METHYL-4-OXO-7(1-PIPERAZINYL)-4H-(1,3)THIAZETO(3,2-A)QUINOLINE-3-CARBOYLIC ACID ETHYL ESTER PRULIFLOXACIN INTERMEDIATE 2 ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate 5-ethyl-6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-1H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate 1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic acid, 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-, ethyl ester Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiaz... 1,6-dimethyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazetidino[3,2-a]quinoline-3-carboxylic acid Ethyl 6-fluoro-1-methy1-4-0x0-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-alquinoline-3-carboxylate Tilorone Impurity 2 PL-10 Prulifloxacin InterMediate PL-1 113028-17-4 C18H20FN3O3S Other Products API intermediates PRULIFLOXACIN