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Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Structure
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate structure
CAS No.
769195-26-8
Chemical Name:
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
Synonyms
RETAG-003;Sitagliptin-10;Sitagliptin Impurity 55;Sitagliptin EP Impurity 17;3-oxo-4-(2,4,5-trifluorophenyl;Methyl 3-oxo-4-(2,4,5-trifluorophenyl);Methyl 2,4,5-trifluoro-b-oxo-benzenebutanoate;Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate;Benzenebutanoicacid,2,4,5-trifluoro-b-oxo-,Methylester;2,4,5-Trifluoro-β-oxo-benzenebutanoic Acid Methyl Ester
CBNumber:
CB01010402
Molecular Formula:
C11H9F3O3
Molecular Weight:
246.19
MDL Number:
MFCD09833197
MOL File:
769195-26-8.mol
MSDS File:
SDS
Last updated:2024-03-22 17:12:53
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Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Properties

Melting point 40-41 °C
Boiling point 273.3±35.0 °C(Predicted)
Density 1.330±0.06 g/cm3(Predicted)
refractive index 1.469
Flash point 115.5±20.8 °C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 9.95±0.46(Predicted)
color Pale Yellow to Light Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301+H311-H315-H319
Precautionary statements  P501-P270-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P405
HS Code  2918300090

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M320785 Methyl3-Oxo-4-(2,4,5-trifluorophenyl)butanoate 769195-26-8 1g $60 2021-12-16 Buy
TRC M320785 Methyl3-Oxo-4-(2,4,5-trifluorophenyl)butanoate 769195-26-8 5g $110 2021-12-16 Buy
American Custom Chemicals Corporation HCH0037407 METHYL 3-OXO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOATE 95.00% 769195-26-8 5G $909.56 2021-12-16 Buy
Medical Isotopes, Inc. 60177 Methyl3-Oxo-4-(2,4,5-trifluorophenyl)butanoate 769195-26-8 100g $950 2021-12-16 Buy
AK Scientific Z1749 Methyl3-oxo-4-(2,4,5-trifluorophenyl)butanoate 769195-26-8 1g $104 2021-12-16 Buy
Product number Packaging Price Buy
M320785 1g $60 Buy
M320785 5g $110 Buy
HCH0037407 5G $909.56 Buy
60177 100g $950 Buy
Z1749 1g $104 Buy

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Chemical Properties,Uses,Production

Chemical Properties

Off-white solid

Uses

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is a useful synthetic intermediate in the synthesis of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase (DPP) IV inhibitor for the treatment of type II diabetes.

Preparation

The preparation of methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is as follows:Stage 1: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile for 3.5h;Stage 2: monomethyl monopotassium malonate With triethylamine; magnesium chloride In acetonitrile at 50℃; for 8h;Stage 3: In acetonitrile at 30℃; for 26h.

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate synthesis

38330-80-2
209995-38-0
769195-26-8
Synthesis of Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate from Potassium 3-methoxy-3-oxopropanoate and 2,4,5-Trifluorophenylacetic acid

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Preparation Products And Raw materials

Raw materials

Benzeneacetyl chloride, 2,4,5-trifluoro- Potassium 3-methoxy-3-oxopropanoate 2,4,5-Trifluorophenylacetic acid Benzenebutanoic acid, 2,4,5-trifluoro-β-hydroxy-, methyl ester 5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione
Methyl bromoacetate Methanol

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Preparation Products

(Z)-Methyl 3-aMino-4-(2,4,5-trifluorophenyl)but-2-enoate Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Suppliers

Global( 154)Suppliers
Supplier Tel Email Country ProdList Advantage
Xinxiang Hongqi District Houyuan Trading Co.,Ltd
+86-0373-3695376 +86-13937349994 HYJM@houyuanjm.com China 300 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7377 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
Anqing Chico Pharmaceutical Co., Ltd. 		15380796838 chloewu@chicopharm.cn CHINA 341 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Supplier Advantage
Xinxiang Hongqi District Houyuan Trading Co.,Ltd
58
Henan Fengda Chemical Co., Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Anqing Chico Pharmaceutical Co., Ltd. 		58
career henan chemical co 		58
Standardpharm Co. Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate pictures 2024-03-23 Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
769195-26-8
 US $5.00-0.10 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER pictures 2023-05-31 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER
769195-26-8
 US $0.00 / Kg 1Kg 99.0% up 50 tons per month Xinxiang Hongqi District Houyuan Trading Co.,Ltd
Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate pictures 2023-05-31 Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
769195-26-8
 US $0.00 / Kg 1Kg 99.0% up 50 tons per month Xinxiang Hongqi District Houyuan Trading Co.,Ltd

769195-26-8(Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate)Related Search:

Succinylcholine Chloride Acarbose Ethambutol Paroxetine Sitagliptin N-Phoshate IMpurity
(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one Sitagliptin phosphate Sitagliptin Impurity 31 Sitagliptin impurity H HCl Sitagliptin Impurity 34
(S)-Sitagliptin Phosphate Sitagliptin Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)- (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate 2,4,5-TRIFLUOROBENZYL CHLORIDE
2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate

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3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER 2,4,5-TRIFLUORO-BETA-OXO-BENZENEBUTANOIC ACID METHYL ESTER Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate 4-(2,4,5 )triflorophenyl 3-oxobutanoic acid, Methy ester 3-oxo-4-(2,4,5-trifluorophenyl Benzenebutanoicacid,2,4,5-trifluoro-b-oxo-,Methylester Methyl 2,4,5-trifluoro-b-oxo-benzenebutanoate Methyl 3-oxo-4-(2,4,5-trifluorophenyl) RETAG-003 Sitagliptin Impurity 55 4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester Sitagliptin-10 3-oxo-4-(2,4,5-trifluorophenyl)butanoic acid methyl ester Benzenebutanoic acid, 2,4,5-trifluoro-β-oxo-, methyl ester Sitagliptin EP Impurity 17 2,4,5-Trifluoro-β-oxo-benzenebutanoic Acid Methyl Ester ethyl (S)-3-acetamido-4-(2,4,5-trifluorophenyl)butanoate 769195-26-8