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PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED

PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED structure

CAS No.: 201422-03-9

Chemical Name:: PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED

Synonyms: MYR-GRTGRRNAI-NH2;PKI 14-22 amide, myr;PKI 14-22 AMIDE, MYRISTOYLATED;PKI 14-22 AMIDE, CELL-PERMEABLE;MYRISTOYLATED PKI (14-22) AMIDE;PROTEIN KINASE A INHIBITOR 14-22 AMIDE, MYRISTOYLATED;MYRISTOYLATED PROTEIN KINASE A INHIBITOR AMIDE 14-22, CELL-PERMEABLE;PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED;L-Isoleucinamide, N-(1-oxotetradecyl)glycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl-

CBNumber:: CB0101910

Molecular Formula:: C53H100N20O12

Molecular Weight:: 1209.49

MDL Number:: MFCD01076529

MOL File:: 201422-03-9.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED Properties

storage temp.	-20°C
solubility	Soluble to 1 mg/ml in DMSO
form	Solid.

PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	2546	PKI14-22amide,myristoylated	201422-03-9	1	$145	2021-12-16	Buy
ApexBio Technology	B9009	PKI14-22amide,myristoylated	201422-03-9	1mg	$219	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0000526	MYRISTOYLATED PKI (14-22) AMIDE, CELL-PERMEABLE PKA INHIBITOR 95.00%	201422-03-9	1MG	$660.95	2021-12-16	Buy

Product number	Packaging	Price	Buy
2546	1	$145	Buy
B9009	1mg	$219	Buy
KIN0000526	1MG	$660.95	Buy

PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED Chemical Properties,Uses,Production

Biological Activity

myristoylated pki (14-22) amide is an effective inhibitor of camp-dependent protein kinase (pka) and blocks hyperalgesia produced by spinal administration of 8-bromo-camp. [1]pkas are the major mediators of camp signaling in eukaryotes. pkas play an important role in several biological processes such as gene expression, apoptosis, tissue differentiation and cellular proliferation. pkas play these functions through the phosphorylation of protein substrates at serine/threonine residues. [2]pkas play a key role in neutrophil phagocytosis. camp/pkas regulate f-actin reorganization during receptor-mediated phagocytosis, particularly triggered by igg-fcr interaction. myristoylated pki 14-22 amide reduced the igg-mediated phagocytic response in a manner of dose-dependent. when the concentration is higher than 10 μm, pki 14-22 amide can inhibit neutrophil adhesion, which make the phagocytosis measurements impossible to perform. [1]because the unregulated activity of pka in mammalian cells has been implicated in the pathogenesis of several types of cancer, the development of pki (14–22) amide has been pursued as a potential treatment for these types of cancer and many other diseases related with pkas.[1,2]

storage

Store at -20°C

References

[1] ydrenius l1, majeed m, etal. , activation of camp-dependent protein kinase is necessary for actin rearrangements in human neutrophils during phagocytosis. j leukoc biol. 2000 apr;67(4):520-8.
[2] swierczewski be, davies sj. developmental regulation of protein kinase a expression and activity in schistosoma mansoni. int j parasitol. 2010 jul;40(8):929-35.

PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED Preparation Products And Raw materials

Raw materials

Preparation Products

PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED Suppliers

Global( 40)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Creative Peptides		info@creative-peptides.com	United States	6084	56
Nanjing Leon Biological Technology Co., Ltd.	17705183659	sales@njleonbiotech.com	China	5504	55
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919	eric@peptidego.com	China	6119	58

Supplier	Advantage
BOC Sciences	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nanjing Doge Biomedical Technology Co., Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Creative Peptides	56
Nanjing Leon Biological Technology Co., Ltd.	55
Hangzhou Peptidego Biotech Co.,Ltd.	58

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PKI 14-22 AMIDE, CELL-PERMEABLE PKI 14-22 AMIDE, MYRISTOYLATED PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED PROTEIN KINASE A INHIBITOR 14-22 AMIDE, MYRISTOYLATED MYRISTOYLATED PKI (14-22) AMIDE MYRISTOYLATED PROTEIN KINASE A INHIBITOR AMIDE 14-22, CELL-PERMEABLE MYR-GRTGRRNAI-NH2 L-Isoleucinamide, N-(1-oxotetradecyl)glycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl- PKI 14-22 amide, myr 201422-03-9 C53H100N20O12