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3-Amino-2,2-dimethylpropionamide

3-Amino-2,2-dimethylpropionamide Structure
3-Amino-2,2-dimethylpropionamide structure
CAS No.
324763-51-1
Chemical Name:
3-Amino-2,2-dimethylpropionamide
Synonyms
Aliskiren Inter-5;3-aMino-2,2-diMethyl-;ALISKIREN InterMediates/ AM4;3-Amino-2,2-dimethylpropiomide;3-AMino-2,2-diMethylpropinaMid;3-Amino-2,2-dimethylpropanamide;3-Amino-2,2-dimethylpropionamide;PropanaMide, 3-aMino-2,2-diMethyl-;2-(aminomethyl)-2-methylpropanamide;3-amino-2,2-dimethylpropionic acid amide
CBNumber:
CB01094136
Molecular Formula:
C5H12N2O
Molecular Weight:
116.16
MDL Number:
MFCD06797568
MOL File:
324763-51-1.mol
MSDS File:
SDS
Last updated:2025-08-16 20:45:37
Product description Number Pack Size Price
3-Amino-2,2-dimethylpropanamide A607370 100mg $50
3-Amino-2,2-dimethylpropanamide A607370 5G $450
3-Amino-2,2-dimethylpropionamide 4148-1-38 100g $450
3-AMINO-2,2-DIMETHYLPROPIONAMIDE 95.00% CHM0069273 1G $867.1
3-AMINO-2,2-DIMETHYLPROPIONAMIDE 95.00% CHM0069273 2.5G $1255.54
More product size
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3-Amino-2,2-dimethylpropionamide Properties

Melting point 74-75 °C
Boiling point 271 °C
Density 1.004
Flash point 117 °C
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO, Methanol
pka 16.45±0.50(Predicted)
form Solid
color White to Off-White
InChI InChI=1S/C5H12N2O/c1-5(2,3-6)4(7)8/h3,6H2,1-2H3,(H2,7,8)
InChIKey HKQZJXVIXAPOPZ-UHFFFAOYSA-N
SMILES C(N)(=O)C(C)(C)CN
CAS DataBase Reference 324763-51-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338-P310

3-Amino-2,2-dimethylpropionamide price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A607370 3-Amino-2,2-dimethylpropanamide 324763-51-1 100mg $50 2021-12-16 Buy
TRC A607370 3-Amino-2,2-dimethylpropanamide 324763-51-1 5G $450 2021-12-16 Buy
SynQuest Laboratories 4148-1-38 3-Amino-2,2-dimethylpropionamide 324763-51-1 100g $450 2021-12-16 Buy
American Custom Chemicals Corporation CHM0069273 3-AMINO-2,2-DIMETHYLPROPIONAMIDE 95.00% 324763-51-1 1G $867.1 2021-12-16 Buy
American Custom Chemicals Corporation CHM0069273 3-AMINO-2,2-DIMETHYLPROPIONAMIDE 95.00% 324763-51-1 2.5G $1255.54 2021-12-16 Buy
Product number Packaging Price Buy
A607370 100mg $50 Buy
A607370 5G $450 Buy
4148-1-38 100g $450 Buy
CHM0069273 1G $867.1 Buy
CHM0069273 2.5G $1255.54 Buy

3-Amino-2,2-dimethylpropionamide Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

3-Amino-2,2-dimethylpropionamide is a kind of Reagent, used in the synthesis of Aliskiren.

Synthesis

2-Cyano-2-MethylpropanaMide

7505-93-3

3-Amino-2,2-dimethylpropionamide

324763-51-1

The general procedure for the synthesis of 3-amino-2,2-dimethylpropionamide from 2-cyano-2-methylpropionamide is as follows: embodiment 5 (according to the present invention) Preparation of 3-amino-2,2-dimethylpropionamide: The product of embodiment 4 was dissolved in 840 mL of methanol-ammonia mixture (containing 169 g NH3/kg), which was subsequently transferred to an autoclave. To this was added 47.9 g of Raney Ni catalyst. The reaction mixture was stirred for hydrogenation at 60-70 °C and 5 bar hydrogen pressure for 10 hours. When analysis confirmed that the feedstock was completely consumed, the reaction mixture was filtered, the filter cake was washed with methanol, and the filtrate was subsequently evaporated to give 160 g (97% yield) of crude product. The crude product was dissolved in 800 mL of isopropanol-toluene (1:9, v/v) mixed solvent for recrystallization. Finally, 124 g (78% overall yield) of the target product 3-amino-2,2-dimethylpropionamide was obtained.

References

[1] Patent: WO2012/21446, 2012, A2. Location in patent: Page/Page column 30-31
[2] Patent: WO2010/112482, 2010, A1. Location in patent: Page/Page column 29
[3] Tetrahedron Letters, 2005, vol. 46, # 37, p. 6337 - 6340
[4] Patent: WO2011/148392, 2011, A1. Location in patent: Page/Page column 64
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 3, p. 957 - 971

3-Amino-2,2-dimethylpropionamide synthesis

4300-97-4
324763-51-1
Synthesis of 3-Amino-2,2-dimethylpropionamide from 3-Chloropivaloyl chloride

3-Amino-2,2-dimethylpropionamide Preparation Products And Raw materials

Raw materials

3-Pyrazolidinone, 4,4-dimethyl- 3-Chloro-2,2-dimethylpropanamide METHYL 3-AMINO-2,2-DIMETHYLPROPANOATE 3-AMINO-2,2-DIMETHYL-PROPANOIC ACID 2-Cyano-2-MethylpropanaMide
2,2-DIMETHYLCYANOACETATE METHYL ESTER 2-CYANO-2-METHYLPROPIONIC ACID ETHYL ESTER 3N-Benzyloxycarbonyl 3-Amino-2,2-dimethylpropanamide 3-BROMO-2,2-DIMETHYLPROPIONIC ACID 3-Hydroxypivalic acid
3-Chloropivaloyl chloride

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Preparation Products

3-Amino-2,2-dimethylpropionamide Suppliers

Global( 178)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8768 58
Hebei Fengjia New Material Co., Ltd 		+86-0311-87836622 +86-18712993135 sales01@tairunfaz.com China 8051 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29847 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10405 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2952 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Fengjia New Material Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Jinan Finer Chemical Co., Ltd 		58
Xiamen AmoyChem Co., Ltd 		58
Hubei xin bonus chemical co. LTD 		58
Alchem Pharmtech,Inc. 		58

View Lastest Price from 3-Amino-2,2-dimethylpropionamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Amino-2,2-dimethylpropionamide pictures 2025-12-03 3-Amino-2,2-dimethylpropionamide
324763-51-1
 US $10.00 / kg 1kg 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
3-Amino-2,2-dimethylpropionamide pictures 2025-12-01 3-Amino-2,2-dimethylpropionamide
324763-51-1
 US $0.00 / kg 1kg 98% 10000KGS Shaanxi Dideu New Materials Co. Ltd
3-Amino-2,2-dimethylpropionamide pictures 2025-11-18 3-Amino-2,2-dimethylpropionamide
324763-51-1
 US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited

3-Amino-2,2-dimethylpropionamide Spectrum

3-Amino-2,2-dimethylpropionamide(324763-51-1)1HNMR

324763-51-1(3-Amino-2,2-dimethylpropionamide)Related Search:

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2-(aminomethyl)-2-methylpropanamide 3-amino-2,2-dimethylpropionic acid amide ALISKIREN InterMediates/ AM4 3-Amino-2,2-dimethylpropanamide 3-Amino-2,2-dimethylpropionamide 3-AMino-2,2-diMethylpropinaMid Aliskiren Inter-5 PropanaMide, 3-aMino-2,2-diMethyl- 3-Amino-2,2-dimethylpropiomide 3-aMino-2,2-diMethyl- 3-Amino-2,2-dimethylpropionamide ISO 9001：2015 REACH 3-Amino-2,2-dimethylpropionamide - [A12146] 324763-51-1 Other APIs Pharmaceutical intermediate Amines Intermediates & Fine Chemicals Pharmaceuticals aliskiren