5-Hydroxytryptophan

5-Hydroxytryptophan Properties

Melting point	298-300°C
Boiling point	361.16°C (rough estimate)
Density	1.484
refractive index	1.5200 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	solid
pka	2.22±0.10(Predicted)
color	Off-White to Pale Beige
Water Solubility	Soluble in water (4 mg/ml at 25°C), methanol.
Merck	14,4847
BRN	88199
InChIKey	LDCYZAJDBXYCGN-UHFFFAOYSA-N
CAS DataBase Reference	56-69-9(CAS DataBase Reference)
EWG's Food Scores	1
EPA Substance Registry System	Tryptophan, 5-hydroxy- (56-69-9)

SAFETY

Risk and Safety Statements

Safety Statements	26
WGK Germany	3
RTECS	YN7100000
PackingGroup	III

5-Hydroxytryptophan price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	797103	5-Hydroxy-DL-tryptophan	56-69-9	5mg	$110	2022-05-15	Buy
Alfa Aesar	A12237	DL-5-Hydroxytryptophan, 99%	56-69-9	1g	$54.2	2021-12-16	Buy
Alfa Aesar	A12237	DL-5-Hydroxytryptophan, 99%	56-69-9	5g	$227	2021-12-16	Buy
TRC	H975700	5-HydroxyTryptophan	56-69-9	5g	$140	2021-12-16	Buy
TRC	H975700	5-HydroxyTryptophan	56-69-9	50mg	$65	2021-12-16	Buy

Product number	Packaging	Price	Buy
797103	5mg	$110	Buy
A12237	1g	$54.2	Buy
A12237	5g	$227	Buy
H975700	5g	$140	Buy
H975700	50mg	$65	Buy

5-Hydroxytryptophan Chemical Properties,Uses,Production

Description

5-Hydroxytryptophan (5-HTP) is an aromatic amino acid naturally produced by the body from the essential amino acid L-tryptophan (LT). Produced commercially by extraction from the seeds of the African plant, Griffonia simplicifolia, 5-HTP has been used clinically for over 30 years. The clinical efficacy of 5-HTP is due to its ability to increase production of serotonin in the brain.

Chemical Properties

Off-White to Pale Beige Solid

Originator

Levotonine,Panmedica,France,1973

Uses

A metabolite of Tryptophan. 5-Hydroxytryptophan (5-HTP) is a direct 5-hydroxytryptamine (5-HT) precursor used to assess central serotonergic function.

Uses

5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid, tryptophan, to serotonin. Clinical studies suggest that 5-HTP supports healthy serotonin levels. In the body, 5-HTP converts to serotonin with the enzymatic removal of a carboxyl group (COOH). Serotonin is an important neurotransmitter involved in the regulation of endocrine and brain activity responsible for emotion, appetite and sleep/wake cycles.?

Application

5-hydroxytryptophan is a dietary supplement made from the seeds of the African plant Griffonia simplicifolia.
5-hydroxytryptophan has been used in alternative medicine as a possibly effective aid in treating depression or fibromyalgia.
Other uses not proven with research have included insomnia, alcohol withdrawal, headaches, premenstrual syndrome, binge-eating related to obesity, attention deficit disorder, and muscle spasms in the mouth.
5-hydroxytryptophan is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Manufacturing Process

Preparation of 5-Hydroxytryptophan: 0.4 gram palladium chloride and 1.7 grams acid-washed charcoal were suspended in 157 ml water and hydrogenated at room temperature and atmospheric pressure until no further hydrogen uptake occurred. A suspension of 14.2 grams 5- benzyloxytryptophan in 175 ml ethyl alcohol was added and the mixture hydrogenated under similar conditions. A hydrogen uptake slightly in excess of theory was obtained. The suspension was warmed for a few minutes on the steam bath and filtered hot. The filter-cake was washed with hot water (3 x 20 ml) and the filtrate evaporated to 20 ml under reduced pressure in a nitrogen atmosphere.
The resultant mass of colorless crystals was triturated with 250 ml ice-cold ethyl alcohol under hydrogen, filtered, and washed with cold ethyl alcohol (2 x 15 ml). The 5-hydroxytryptophan (6.9 grams, 69%) had MP (sealed evacuated tube) 288°C, with softening, finally melting at 249° to 247°C (decomposition). Concentration of the liquors under reduced pressure in a nitrogen atmosphere, and trituration as before, gave a second crop (0.9 gram, 9%). The combined crops (7.8 grams) were dissolved in 120 ml hot water, charcoal added, and the mixture filtered hot. The filtrate was concentrated in a nitrogen atmosphere under reduced pressure and ethyl alcohol added. The 5-hydroxytryptophan then crystallized as colorless microneedles (6.5 grams,65%), had MP (sealed evacuated tube) 290°C, with slight softening, finally melting at 295° to 297°C (decomposition).

Therapeutic Function

Antidepressant, Antiepileptic

Biochem/physiol Actions

Immediate precursor of serotonin; L-aromatic amino acid decarboxylase substrate.

Source

5-HTP is derived from the Griffonia simplicifolia plant. Hypo-allergenic plant fiber is derived from pine cellulose.

Mode of action

5-Hydroxytryptophan acts primarily by increasing levels of serotonin within the central nervous system. Other neurotransmitters and CNS chemicals, such as melatonin, dopamine, norepinephrine, and beta-endorphin have also been shown to increase following oral administration of 5-HTP. This ability to increase not only serotonin levels in the brain, but also dopamine and norepinephrine, allows 5-HTP to produce some significant and unique effects on brain chemistry and on serotonin-related conditions which other substances, including LT, cannot duplicate.?

5-Hydroxytryptophan synthesis

Synthesis of 5-Hydroxytryptophan from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy- and 5-Hydroxytryptophan and N,N,N',N'-Tetramethyl-1,4-phenylenediamine and Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

5-Hydroxytryptophan Preparation Products And Raw materials

Raw materials

Sulfuric acid Sodium hydroxide Hydrogen Hydrochloric acid Sodium nitrite

STANNOUS CHLORIDE 4-Benzyloxyaniline hydrochloride Diethyl acetamidomalonate Acrolein

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Preparation Products

N,N,N',N'-Tetramethyl-1,4-phenylenediamine

5-Hydroxytryptophan Suppliers

Global( 341)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan DaKen Chemical CO.,LTD.	+86-371-66670886	info@dakenchem.com	China	16666	58
Henan Tianfu Chemical Co.,Ltd.	0371-55170693	info@tianfuchem.com	China	22021	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3623	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29959	58
Chengdu Biopurify Phytochemicals Ltd.	+8618482058008	maggie@biopurify.com	China	2712	58
Hubei Jusheng Technology Co.,Ltd.	86-18871470254	linda@hubeijusheng.com	CHINA	28229	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19969	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282 +86-19930503282	alice@crovellbio.com	China	5953	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	CHINA	3001	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58

Supplier	Advantage
Henan DaKen Chemical CO.,LTD.	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Accela ChemBio Inc.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Shaanxi Pioneer Biotech Co., Ltd .	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	58

View Lastest Price from 5-Hydroxytryptophan manufacturers

Release date	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-03-21	5-Hydroxy-DL-tryptophan 56-69-9	US $1.00 / KG	1KG	99%	100KG	Hong Kong Tiansheng New Material Trading Co., Ltd
2022-02-25	5-HTP;5-hydroxytryptophan 56-69-9	US $1.00 / g	10g	99% HPLC	1000kg	Guangzhou Biocar Biotechnology Co.,Ltd.
2022-02-25	5-Hydroxytryptophan 56-69-9	US $1.00 / Kg/Bag	1Kg/Bag	99%	100KG	Hong Kong Tiansheng New Material Trading Co., Ltd

5-Hydroxy-DL-tryptophan
56-69-9
US $1.00 / KG
99%
Hong Kong Tiansheng New Material Trading Co., Ltd

5-HTP;5-hydroxytryptophan
56-69-9
US $1.00 / g
99% HPLC
Guangzhou Biocar Biotechnology Co.,Ltd.

5-Hydroxytryptophan
56-69-9
US $1.00 / Kg/Bag
99%
Hong Kong Tiansheng New Material Trading Co., Ltd

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DL-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID 5-Hydroxytryptophan(5-HTP) DL-2-Amino-3-(5-hydroxyindolyl)propionic acid, DL-5-HTP 5-HTP (Griffonia Seeds P.E.) 5-Hydroxy-α-amino-1H-indole-3-propionic acid NSC-92523 USAF CB-96 2-azanyl-3-(5-hydroxy-1H-indol-3-yl)propanoic acid 5-HTP AMino acid 5-Hydroxytryptophan (CAS 56-69-9) 5-Hydroxy-DL-tryphophane Tryptophan, 5-hydroxy- 5-Hydroxytryptophan (5-HTP) Synonyms DL-5-Hydroxytryptophan 5-Hydroxytryptophan DL-5-Hydroxytryptophan 5-HYDROXYTRYPTOPHAN 2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)-PROPIONIC ACID 5-hydroxy-tryptopha 5-hydroxytryptophane 5-hydroxytrytophan nci-c56644 TIMTEC-BB SBB003354 5-HydroxyTryptophane (5-HTP) 5-Hydroxy-L-Tryptophan 5-Hydroxy-Tryptophan DL-5-HYDROXYTRYPTOPHAN 99% DL-5-HYDROXYTRYPTOPHAN, 99+% BY HPLC REFERENCE STANDARD 5-Hydroxytryptophan20%50%90%99% 5-Hydroxy-DL-tryptophane H-DL-Trp(5-OH)-OH 5-Hydroxytryptophan USP/EP/BP (114-03-4) 5-hydroxytryptophan 5-Hydroxytryptophan 56-69-9 JACS-56-69-9 5-Hydroxy-DL-tryptophan> DL-5-HTP DL-5-HYDROXYTRYPTOPHAN HYDROXYTRYPTOPHAN 5-HYDROXY-DL-TRYPTOPHAN 2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID 56-69-9 Indoles Tryptophans Inhibitors Plant extracts Herb extract chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Amines Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Standard extract