SMZ/TMP
- CAS No.
- 8064-90-2
- Chemical Name:
- SMZ/TMP
- Synonyms
- TMP-SMX;SMZ/TMP;Septrim;Chemitrim;Trimforte;Trimethoprimsulfa;Co-Trimoxazole (CTX), 95%;Trimethoprim-Sulfamethoxazole;Sulfamethoxazole/Trimethoprim;TRIMETHOPRIM/SULPHAMETHOXAZOLE
- CBNumber:
- CB01105579
- Molecular Formula:
- C24H29N7O6S
- Molecular Weight:
- 543.6
- MDL Number:
- MOL File:
- 8064-90-2.mol
| storage temp. | -20°C |
|---|---|
| solubility | DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL,Ethanol: 0.3mg/mL |
| form | liquid |
| color | colorless to faint yellow |
| BCS Class | 4/4 |
| NCI Dictionary of Cancer Terms | trimethoprim-sulfamethoxazole |
| NCI Drug Dictionary | trimethoprim-sulfamethoxazole |
| EPA Substance Registry System | Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, mixt. with 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine (8064-90-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H317-H319-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-43 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| RTECS | UV8240000 |
| Toxicity | LD50 orally in mice: 5513 mg/kg (Yamamoto) |
SMZ/TMP price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A2487 | Cotrimoxazole, Ready Made Solution | 8064-90-2 | 1ml | $619 | 2024-03-01 | Buy |
| TRC | C725300 | Cotrimoxazole | 8064-90-2 | 2.5g | $185 | 2021-12-16 | Buy |
| TRC | C725300 | Cotrimoxazole | 8064-90-2 | 10g | $520 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004695 | CO-TRIMOXAZOLE 95.00% | 8064-90-2 | 5MG | $550 | 2021-12-16 | Buy |
| AK Scientific | 1199CC | Sulfamethoxazoleandtrimethoprim | 8064-90-2 | 5g | $761 | 2021-12-16 | Buy |
SMZ/TMP Chemical Properties,Uses,Production
Uses
Cotrimoxazole is an antibiotic. Pseudomonas aeruginosa has a drug resistant rate of 66% in the years 2010-2013.
World Health Organization (WHO)
The combination of sulfamethoxazole and trimethoprim (5:1) was introduced in 1971 for the treatment of a wide variety of bacterial infections. Its use has been associated with severe sensitivity reactions, many of which have been attributed to the sulphonamide component. Elderly people seem to be more vulnerable. The World Health Organization has no information further to the above concerning restrictive action taken on this combination.
Side effects
Trimethoprim/sulfamethoxazole on a daily basis has a rapid onset of action
but has rare associated side effects of bone marrow suppression and toxic
epidermal necrolysis (TEN).
Nausea, vomiting, and anorexia are generally dose related.
Hypersensitivity reactions (including Stevens-Johnson syndrome and hematologic
reactions) occur in <5% of patients.
Dosage forms
One to two tablets a day. Trimethoprim is dosed at 200 mg/24 hours given either q.d. or b.i.d.
SMZ/TMP Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Shandong Mopai Biotechnology Co., Ltd | 13053322091 13053322091 | admin@mopaikeji.com | China | 10969 | 58 |