5-Bromo-2-iodopyridine
- CAS No.
- 223463-13-6
- Chemical Name:
- 5-Bromo-2-iodopyridine
- Synonyms
- 2-IODO-5-BROMOPYRIDINE;CAS:223463-13-6;5-Brom-2-iodpyridin;5-bromo-2-lodopyridine;5-BROMO-2-IDIOPYRIDINE;5-BROMO-2-IODOPYRIDINE;5-CroMo-2-iodopyridine;2-iodine-5-broMopyridine;PYRIDINE, 5-BROMO-2-IODO-;5-Bromo-2-Iodopyridine99%
- CBNumber:
- CB0111175
- Molecular Formula:
- C5H3BrIN
- Molecular Weight:
- 283.89
- MDL Number:
- MFCD00691506
- MOL File:
- 223463-13-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-2-iodopyridine 97% | 569607 | 5g | $44.52 |
| 5-Bromo-2-iodopyridine 97% | 569607 | 25g | $80.5 |
| 5-Bromo-2-iodopyridine >97.0%(GC) | B2877 | 5g | $47 |
| 5-Bromo-2-iodopyridine >97.0%(GC) | B2877 | 25g | $186 |
| 5-Bromo-2-iodopyridine | B687630 | 10g | $65 |
| More product size | |||
| Melting point | 113-117 °C (lit.) |
|---|---|
| Boiling point | 258.8±20.0 °C(Predicted) |
| Density | 2.347±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol (Slightly) |
| pka | -0.51±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to beige |
| Sensitive | Light Sensitive |
| BRN | 2119 |
| Stability | Light Sensitive |
| InChI | InChI=1S/C5H3BrIN/c6-4-1-2-5(7)8-3-4/h1-3H |
| InChIKey | HSNBRDZXJMPDGH-UHFFFAOYSA-N |
| SMILES | C1(I)=NC=C(Br)C=C1 |
| CAS DataBase Reference | 223463-13-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, LIGHT SENSITIVE | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Bromo-2-iodopyridine price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 569607 | 5-Bromo-2-iodopyridine 97% | 223463-13-6 | 5g | $44.52 | 2025-07-31 | Buy |
| Sigma-Aldrich | 569607 | 5-Bromo-2-iodopyridine 97% | 223463-13-6 | 25g | $80.5 | 2025-07-31 | Buy |
| TCI Chemical | B2877 | 5-Bromo-2-iodopyridine >97.0%(GC) | 223463-13-6 | 5g | $47 | 2025-07-31 | Buy |
| TCI Chemical | B2877 | 5-Bromo-2-iodopyridine >97.0%(GC) | 223463-13-6 | 25g | $186 | 2025-07-31 | Buy |
| TRC | B687630 | 5-Bromo-2-iodopyridine | 223463-13-6 | 10g | $65 | 2021-12-16 | Buy |
5-Bromo-2-iodopyridine Chemical Properties,Uses,Production
Chemical Properties
Light yellow Cryst
Uses
5-Bromo-2-iodopyridine may be used in the synthesis of the following:
- 5-bromopyridyl-2-magnesium chloride via reaction with isopropylmagnesium chloride solution
- 5-bromo-2-pyridylzinc iodide via treatment with active zinc in tetrahydrofuran
- 5-bromo-2-(trifluoromethyl)pyridine via halogen/trifluoromethyl displacement reaction
- (5-bromopyridin-2-yl)zinc(II) chloride via multi-step synthesis
- 5,5′-dibromo-2,2′-bipyridine via multi-step synthesis
Synthesis
624-28-2
223463-13-6
The general procedure for the synthesis of 5-bromo-2-iodopyridine from 2,5-dibromopyridine was as follows: an aqueous solution of 57% hydriodic acid (HI) was added to a reaction system containing 2,5-dibromopyridine (12.60 g, 53.2 mmol) and sodium iodide (NaI, 11.40 g, 76 mmol). The reaction mixture was heated to reflux for 24 h, subsequently cooled to room temperature and diluted with 100 mL of water. The pH of the mixture was adjusted to alkaline with sodium bicarbonate (NaHCO3), and then treated with the addition of sodium dithionite (Na2S2O4) until the solution became colorless. The reaction mixture was extracted with dichloromethane (DCM, 5 x 60 mL), the organic phases were combined and dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure and the obtained residue was collected by filtration, washed with ether (Et2O, 60 mL) and dried over air to give 5-bromo-2-iodopyridine (8.28 g, 55% yield) as a light gray powder.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 17, p. 4528 - 4532
[2] Chemical Communications, 2012, vol. 48, # 8, p. 1120 - 1122
[3] European Journal of Organic Chemistry, 2003, # 8, p. 1559 - 1568
[4] Journal of Organic Chemistry, 2001, vol. 66, # 2, p. 605 - 608
[5] Organic Letters, 2004, vol. 6, # 26, p. 4905 - 4907
5-Bromo-2-iodopyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Medfine Bio-pharmaceutical Co., Ltd | +86-86-13013810076 +8619921460217 | tina.lv@bio-medfine.com | China | 296 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8753 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| AS WATER CO., LTD. | +86-18994963526 +8618994963526 | 1346073549@qq.com | United Kingdom | 176 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13799 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21597 | 55 |
View Lastest Price from 5-Bromo-2-iodopyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-30 | 5-Bromo-2-iodopyridine
223463-13-6
|
US $8.90 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-11-18 | 5-Bromo-2-iodopyridine
223463-13-6
|
US $1.10 / g | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2025-05-26 | 5-Bromo-2-iodopyridine
223463-13-6
|
US $5.00 / kg | 1kg | 0.99 | 100000 | Hebei Fengjia New Material Co., Ltd |
-
- 5-Bromo-2-iodopyridine
223463-13-6
- US $8.90 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 5-Bromo-2-iodopyridine
223463-13-6
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 5-Bromo-2-iodopyridine
223463-13-6
- US $5.00 / kg
- 0.99
- Hebei Fengjia New Material Co., Ltd
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