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Euphorbiasteroid

Euphorbiasteroid Structure
Euphorbiasteroid structure
CAS No.
28649-59-4
Chemical Name:
Euphorbiasteroid
Synonyms
Euphorbia factor L1;Daughter son sterol;Euphorbiasteroid（EuphorbiaFactor L1）;6,20-Epoxylathyrol phenylacetate diacetate;Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,...;Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate;Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
CBNumber:
CB01118210
Molecular Formula:
C32H40O8
Molecular Weight:
552.66
MDL Number:
MFCD06410946
MOL File:
28649-59-4.mol
MSDS File:
SDS
Last updated:2023-08-30 19:07:15
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Euphorbiasteroid Properties

Melting point 199～200℃
Boiling point 633.1±55.0 °C(Predicted)
Density 1.23
storage temp. 4°C, protect from light
solubility DMSO:15.0(Max Conc. mg/mL);27.14(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);9.05(Max Conc. mM)
form A crystalline solid

SAFETY

Risk and Safety Statements

Safety Statements  24/25
HS Code  29061990

Euphorbiasteroid price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 27822 Euphorbiasteroid 28649-59-4 25mg $121 2024-03-01 Buy
Cayman Chemical 27822 Euphorbiasteroid 28649-59-4 250mg $961 2024-03-01 Buy
Cayman Chemical 27822 Euphorbiasteroid 28649-59-4 50mg $230 2024-03-01 Buy
Cayman Chemical 27822 Euphorbiasteroid 28649-59-4 100mg $411 2024-03-01 Buy
TRC E938885 Euphorbiasteroid 28649-59-4 5mg $55 2021-12-16 Buy
Product number Packaging Price Buy
27822 25mg $121 Buy
27822 250mg $961 Buy
27822 50mg $230 Buy
27822 100mg $411 Buy
E938885 5mg $55 Buy

Euphorbiasteroid Chemical Properties,Uses,Production

Uses

Euphorbiasteroid is a compound used to induce HL-60 cells to apoptosis via promoting Bcl/Bax apoptotic signaling pathway in a dose-dependent manner.

Biological Functions

Euphorbiasteroid, Euphorbia Factor L1 (EFL1) to be specific, with a tricyclic terpenoid skeleton, consisting of fused five-, eleven- and three-membered rings, is a diterpenoid isolated from the seeds of Euhporbia lathyris L. It is reported EFL1 could be helpful to reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, but shows no effect on pro-caspase-9 and pro-caspase-3. EFL1 also could induce apoptosis, and possess anticancer, antiadipogenesis, antiosteoclastogenesis and multi-drug resistance-modulating effect.
Euphorbiasteroid showed effects on adipogenesis of 3T3-L1 pre-adipocytes. Euphorbiasteroid also has the potential to reverse P-glycoprotein (P-gp)-mediated multi-drug resistance (MDR) by using the drug-sensitive human sarcoma cell line MES-SA and its MDR counterpart MES-SA/Dx5.EFL1 inhibited osteoclastogenesis and induced osteoclast apoptosis. Euphorbiasteroid suppressed osteoclast formation and bone resorption at both initial and terminal differentiation stages.

Euphorbiasteroid Preparation Products And Raw materials

Raw materials

Preparation Products

Euphorbiasteroid Suppliers

Global( 123)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3620 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd. 		+8618080483897 sales@biopurify.com China 3424 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282 alice@crovellbio.com China 8823 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shanghai Standard Technology Co., Ltd. 		18502101150 ft-sales@nature-standard.com CHINA 1923 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Chengdu GLP biotechnology Co Ltd 		58
Chengdu Biopurify Phytochemicals Ltd. 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Hebei Guanlang Biotechnology Co., Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
Shanghai Standard Technology Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58

Related articles

View Lastest Price from Euphorbiasteroid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Euphorbiasteroid pictures 2023-08-30 Euphorbiasteroid
28649-59-4
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Euphobiasteroid pictures 2023-02-24 Euphobiasteroid
28649-59-4
 US $0.00 / mg 20mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
Euphorbiasteroid pictures 2021-07-13 Euphorbiasteroid
28649-59-4
 US $1.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
  • Euphobiasteroid pictures
  • Euphobiasteroid
    28649-59-4
  • US $0.00 / mg
  • ≥98%(HPLC)
  • Shanghai Standard Technology Co., Ltd.
  • Euphorbiasteroid pictures
  • Euphorbiasteroid
    28649-59-4
  • US $1.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.

28649-59-4(Euphorbiasteroid)Related Search:

Euphorbia factor L7b beta-Sitosterol Dodecanoic acid ingenol ester Ingenol mebutate 17-Hydroxyisolathyrol
20-DEOXYINGENOL (6R)-6,6aβ,7aβ,8,9,12,12a,12bβ-Octahydro-12α,12aα-dihydroxy-2,2,7,7,9β,11-hexamethyl-7H-6β,9aβ-methano-4H-cyclopenta[9,10]cyclopropa[5,6]cyclodeca[1,2-d]-1,3-dioxin-13-one Euphorbia factor L1 euphorbiafactor L2 DIACETYL BENZOYL LATHYROL
Ingenol (1aR,7bR)-1aα,2,7aα,13,14,14aα-Hexahydro-1,1,6,6,9,9,11,13α-octamethyl-10aαH-2α,12aα-methano-1H,4H-cyclopropa[5,6][1,3]dioxolo[2',3']cyclopenta[1',2':9,10]cyclodeca[1,2-d][1,3]dioxin-15-one Euphorbiasteroid TRANS-CYCLODODECENE

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Daughter son sterol 6,20-Epoxylathyrol phenylacetate diacetate Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester Euphorbia factor L1 Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees (1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate (1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,... Euphorbiasteroid（EuphorbiaFactor L1） 28649-59-4 32H40O8 C32H40O8