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Micafungin sodium

Micafungin sodium structure

CAS No.: 208538-73-2

Chemical Name:: Micafungin sodium

Synonyms: CS-705;Funguard;Mycamine;FK463 Sodium;Mycamine Sodium;Caffeine sodium;Micafungin sodium;Micafungin Sodium Salt;Micafungin sodium, >=98%;FK 463; FUNGUARD; MYCAMINE

CBNumber:: CB01120439

Molecular Formula:: C56H72N9NaO23S

Molecular Weight:: 1294.28

MDL Number:: MFCD08067752

MOL File:: 208538-73-2.mol

MSDS File:: SDS

Last updated:2023-08-21 17:50:07

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Micafungin sodium Properties

Melting point	>180°C (dec.)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form	Solid
color	White to Off-White
Stability	Hygroscopic
CAS DataBase Reference	208538-73-2
FDA UNII	IS1UP79R56

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H361
Precautionary statements	P201-P202-P281-P308+P313-P405-P501

Micafungin sodium price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	18009	Micafungin (sodium salt) ≥95%	208538-73-2	1mg	$32	2024-03-01	Buy
Cayman Chemical	18009	Micafungin (sodium salt) ≥95%	208538-73-2	5mg	$109	2024-03-01	Buy
Cayman Chemical	18009	Micafungin (sodium salt) ≥95%	208538-73-2	10mg	$184	2024-03-01	Buy
Cayman Chemical	18009	Micafungin (sodium salt) ≥95%	208538-73-2	25mg	$381	2024-03-01	Buy
TRC	M342350	MicafunginSodium	208538-73-2	25mg	$595	2021-12-16	Buy

Product number	Packaging	Price	Buy
18009	1mg	$32	Buy
18009	5mg	$109	Buy
18009	10mg	$184	Buy
18009	25mg	$381	Buy
M342350	25mg	$595	Buy

Micafungin sodium Chemical Properties,Uses,Production

Description

The semi-synthetic echinocandin antifungal agent, micafungin sodium (15), is a 1,3-β-glucan synthase inhibitor discovered by Fujisawa. It is for the treatment and prevention of infections caused by Aspergillus and Candida such as fungemia, respiratory mycosis and gastrointestinal mycosis.

Chemical Properties

Off-White Solid

Uses

Micafungin is an echinocandin antifungal that inhibits 1,3-β-D-glucan synthesis. It has fungicidal activity against virtually all species of Candida, including those resistant to fluconazole, and is fungistatic against Aspergillus spp.[Cayman Chemical]

Uses

An echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall, and represent a valuable treatment option for fungal infections.

Uses

Micafungin sodium is the salt of the semi-synthetic cyclic lipopeptide, micafungin, a member of the echinocandin class that was reported in 1999 from Fujisawa in Japan. The sodium salt takes advantage of the aryl sulphate moiety providing improved water solubility and is the preferred salt for pharmaceutical applications. Like all echinocandins, micafungin inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.

Definition

ChEBI: Micafungin sodium is an organic sodium salt and an antibiotic antifungal drug.

brand name

Mycamine(Astellas).

Synthesis

The key intermediate for the side chain of micafungin (15) was prepared by regioselective 1,3-dipolar cycloaddition reaction of 4-methoxycarbonylbenzhydroxamic acid chloride (147) and 4-pentyloxyphenylacetylene (148) with TEA in THF. Basic hydrolysis of thus obtained ester 149 , followed by condensation with 1- hydroxybenzotriazole (HOBT) gave the corresponding activated ester 150 in 95% yield. The cyclic peptide core 151, obtained by acylase-catalyzed hydrolysis of the natural product FR901379, was acylated with 150 to give micafungin (15) in 53% yield.

Synthesis_208538-73-2

Micafungin sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Micafungin sodium Suppliers

Global( 253)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ENBRIDGE PHARMTECH CO., LTD.	+8613812269233	tinayang@enbridgepharm.com	China	303	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
TianYuan Pharmaceutical CO.,LTD	+86-755-23284190 13684996853	sales@tianpharm.com	CHINA	304	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58

Supplier	Advantage
ENBRIDGE PHARMTECH CO., LTD.	58
Henan Bao Enluo International TradeCo.，LTD	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
TianYuan Pharmaceutical CO.,LTD	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from Micafungin sodium manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-23	Micafungin sodium 208538-73-2	US $1.00 / g	1g	99%	10 tons	ANHUI WITOP BIOTECH CO., LTD
2024-04-17	Micafungin sodium 208538-73-2	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2024-01-08	Micafungin Sodium Impurity 208538-73-2	US $10.00-17.00 / kg	10kg	99％	1000	Wuhan Boyuan Import & Export Co., LTD

Micafungin sodium
208538-73-2
US $1.00 / g
99%
ANHUI WITOP BIOTECH CO., LTD

Micafungin sodium
208538-73-2
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

Micafungin Sodium Impurity
208538-73-2
US $10.00-17.00 / kg
99％
Wuhan Boyuan Import & Export Co., LTD

Micafungin sodium Spectrum

Micafungin sodium(208538-73-2)MS

208538-73-2(Micafungin sodium)Related Search:

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Micafungin sodium 1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneuMocandin A0 MonosodiuM Salt Funguard Micafungin SodiuM(FK-463, MycaMine) Mycamine Micafungin Sodium Salt FK463 Sodium Micafungin sodium Mycamine Micafungin sodium, >=98% Pneumocandin A0, 1-[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]-, sodium salt (1:1) CS-705 FK 463; FUNGUARD; MYCAMINE micafungin sodium Impurity Micafungin Sodium (FK 463) Mycamine Sodium Micafungin sodium USP/EP/BP Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12,14a,15,16,17,19,20,23,25a-hexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sulfate Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12 US-DMF No.: 031449 ASMF Approved Micafungin SodiumQ: What is Micafungin Sodium Q: What is the CAS Number of Micafungin Sodium Q: What is the storage condition of Micafungin Sodium Micafungin-D11 Sodium salt 208538-73-2 Micafungin sodium Caffeine sodium Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12,14a,15,16,17,19,20,23,25a-hexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sulfate[FK 463 Sodium Micafungin Sodium (200 mg) (INTERNATIONAL COLD SHIPMENT REQUIRED) Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12,14a,15,16,17,19,20,23,25a-hexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sulfate 208538-73-2 C56H70N9NaO23S C56H70N9O23SNa Inhibitors API