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2-Methyl-2-propyl-1,3-propanediol

2-Methyl-2-propyl-1,3-propanediol Structure
2-Methyl-2-propyl-1,3-propanediol structure
CAS No.
78-26-2
Chemical Name:
2-Methyl-2-propyl-1,3-propanediol
Synonyms
1,3-Propanediol, 2-methyl-2-propyl-;2-methyl-2-propylpropane-1,3-diol;DURANOL;NSC 26233;Dimethylolpentane,97%;Pentane-2,2-dimethanol;2,2-DIMETHYLOL-PENTANE;Carisoprodol iMpurity C;Carisoprodol EP Impurity C;Carisoprodol intermediate H
CBNumber:
CB0114707
Molecular Formula:
C7H16O2
Molecular Weight:
132.2
MDL Number:
MFCD00004696
MOL File:
78-26-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-19 07:28:27
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2-Methyl-2-propyl-1,3-propanediol Properties

Melting point 57-59 °C (lit.)
Boiling point 230 °C/753 mmHg (lit.)
Density 0.9744 (rough estimate)
refractive index 1.4474 (estimate)
Flash point >230 °F
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 14.57±0.10(Predicted)
color White
BRN 1734432
InChI InChI=1S/C7H16O2/c1-3-4-7(2,5-8)6-9/h8-9H,3-6H2,1-2H3
InChIKey JVZZUPJFERSVRN-UHFFFAOYSA-N
SMILES C(O)C(C)(CCC)CO
CAS DataBase Reference 78-26-2(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII YLM5KRU0P4
NIST Chemistry Reference 1,3-Propanediol, 2-methyl-2-propyl-(78-26-2)
EPA Substance Registry System 1,3-Propanediol, 2-methyl-2-propyl- (78-26-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312+P330-P501
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xn
Risk Statements  36-22
Safety Statements  22-24/25-39-26
WGK Germany  1
RTECS  TY9386000
TSCA  TSCA listed
HS Code  2905399590
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
1
0 0

2-Methyl-2-propyl-1,3-propanediol price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M75209 2-Methyl-2-propyl-1,3-propanediol 98% 78-26-2 25g $51.3 2026-04-30 Buy
TCI Chemical D0766 2-Methyl-2-propyl-1,3-propanediol >98.0%(GC) 78-26-2 25g $25 2026-04-30 Buy
TCI Chemical D0766 2-Methyl-2-propyl-1,3-propanediol >98.0%(GC) 78-26-2 500g $219 2026-04-30 Buy
Usbiological M3533-40 2-Methyl-2-propyl-1,3-propanediol 5mg $403 2026-06-03 Buy
TRC TRC-M320590-5G 2-Methyl-2-propyl-1,3-propanediol 78-26-2 5g $80 2026-06-03 Buy
Product number Packaging Price Buy
M75209 25g $51.3 Buy
D0766 25g $25 Buy
D0766 500g $219 Buy
M3533-40 5mg $403 Buy
TRC-M320590-5G 5g $80 Buy

2-Methyl-2-propyl-1,3-propanediol Chemical Properties, Uses, Production

Synthesis

2-Methyl-2-pentenal was hydrogenated at 100°C and 1.3-1.5MPa with a yield of 80%. After obtaining 2-methylpentenal, it was added to 36% formaldehyde, and the reaction was carried out at room temperature. Sodium hydroxide solution was added dropwise. The reaction was exothermic, and the temperature was naturally raised to 70 °C, then heated to 90 °C, added for 1 h, cooled to 60 °C and left to separate layers. The upper layer was washed with water, the washings were combined with the lower layer, and extracted with benzene. The extract and the upper layer were combined, and benzene was recovered by distillation, followed by distillation under reduced pressure to collect a fraction at 160°C (14.7kPa), which was 2-methyl-2-propyl-1,3-propanediol,yield 93%.

Description

2-Methyl-2-propyl-1,3-propanediol is produced either by the salt-free procedure based on aldol addition followed by hydrogenation or by the classical combination of hydroxymethylation and Cannizzaro-type disproportionation with formaldehyde. The production costs are considerably higher than for neopentyl glycol, because the synthesis of 2-methylpentanal from propanal requires two additional steps: aldol condensation and hydrogenation.

Chemical Properties

Whgite Crystalline Solid

Uses

An intermediate in the synthesis of Carisoprodol.

Uses

2-Methyl-2-propyl-1,3-propanediol is mainly used in pharmaceutical applications such as production of dicarbamates. Meprobamate (2-methyl-2-propyl-1,3-propanediol dicarbamate), is used as an anxiolytic drug (tranquilizer). Carisoprodol (N-isopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate), possesses strong centrally-acting muscle relaxant activity.

2-Methyl-2-propyl-1,3-propanediol synthesis

55898-43-6
78-26-2
Synthesis of 2-Methyl-2-propyl-1,3-propanediol from Diethyl methyl propyl malonate

2-Methyl-2-propyl-1,3-propanediol Preparation Products And Raw materials

Raw materials

Methyl valeraldehyde

Preparation Products

Carisoprodol 2-methyl-2-propylpropane-1,3-diyl dinitrate

2-Methyl-2-propyl-1,3-propanediol Suppliers

Global Suppliers ( 199)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771 sales@heowns.com China 14412 57
Maya High Purity Chemicals +86 (573) 82222445 (0)18006601000 452520369 sales@maya-r.com China 11693 57
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Adamas Reagent, Ltd. 59
Chemsky（shanghai）International Co.,Ltd. 50
Syntechem Co.,Ltd 57
Tianjin heowns Biochemical Technology Co., Ltd. 57
Maya High Purity Chemicals 57
Shanghai T&W Pharmaceutical Co., Ltd. 58

View Latest Price from 2-Methyl-2-propyl-1,3-propanediol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Methyl-2-propyl-1,3-propanediol pictures 2026-06-30 2-Methyl-2-propyl-1,3-propanediol
78-26-2
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
2-Methyl-2-Propyl-1,3-Propanediol pictures 2021-10-12 2-Methyl-2-Propyl-1,3-Propanediol
78-26-2
 $10.00 1Kg/Bag 99% 20 tons Hebei Zhanyao Biotechnology Co. Ltd
2-Methyl-2-propyl-1,3-propanediol pictures 2021-08-11 2-Methyl-2-propyl-1,3-propanediol
78-26-2
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2-Methyl-2-propyl-1,3-propanediol Spectrum

2-Methyl-2-propyl-1,3-propanediol(78-26-2)MS2-Methyl-2-propyl-1,3-propanediol(78-26-2)1HNMR2-Methyl-2-propyl-1,3-propanediol(78-26-2)13CNMR2-Methyl-2-propyl-1,3-propanediol(78-26-2)IR12-Methyl-2-propyl-1,3-propanediol(78-26-2)IR22-Methyl-2-propyl-1,3-propanediol(78-26-2)Raman

78-26-2 (2-Methyl-2-propyl-1,3-propanediol) Related Search:

Chloromethyl isopropyl carbonate Cyclopropyl methyl ketone Basic Violet 1 Cyclopentane Propylene glycol
1-Methoxy-2-propanol 1,3-Propanediol Methanol Methyl acrylate Pentane
Tris(hydroxymethyl)nitromethane (R)-(-)-1,2-Propanediol Propyl butyrate Paraquat dichloride Kresoxim-methyl
Acetonitrile 1-Methoxy-2-propyl acetate 2-Methyl-1,3-propanediol

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methyl-2-propyl-2-propanediol-1,3 2-METHYL-2-PROPYL-1,3-PROPANEDIOL,99% 2-METHYL-2-PROPYL-1,3-PROPANDIOL Carisoprodol intermediate H NSC 26233 2-methyl-2-propyl-1,3-propandiol (intermediate of meprobamate or carisoprodol) DURANOL 2-METHYL-2-PROPYL-1,3-PROPANEDIOL [FOR CARISOPRODOL] 2-Propyl-2-methyl-1,3-propanediol Pentane-2,2-dimethanol 2,2-Dimethylolpentane2,2-Bis(hydroxymethyl)pentane 2-Methyl-2-propyl-1,3-propanediol 98% 2-METHYL-2-PROPYL-1,3-PROPANEDIOL 2-METHYL-2-N-PROPYL-1,3-PROPANEDIOL 2,2-Bis(hydroxymethyl)pentane 2,2-Dimethylolpentane Carisoprodol iMpurity C 2-methyl-2-propyl-3-propanediol 3-Propanediol,2-methyl-2-propyl-1 2-Methyl-2-Propylpropan-1,3-Diol Dimethylolpentane,97% 2,2-DIMETHYLOL-PENTANE 2,2-BIS(HYDROXYMETHYL)PENTANE 78-26-2 2-Methyl-2-propyl-1,3-propanediol 2,2-Bis(Hydroxymethyl)Pentane,>99% 2-Methyl-2-propyl-1,3-propanediol > Carisoprodol EP Impurity C 1,3‐Dihydroxy‐2‐methyl‐2‐propylpropane 2-Methyl-2-propy1-1,3-propanediol Bupropion Impurity 4（Bupropion USP RC D）-d9 1,3-Propanediol, 2-methyl-2-propyl- 2-methyl-2-propylpropane-1,3-diol 78-26-2 CH3CCH2OH2CH2CH2CH3 Organic Building Blocks Oxygen Compounds Polyols Building Blocks Building Blocks Chemical Synthesis Organic Building Blocks Oxygen Compounds Pharmaceutical Intermediates (intermediate of meprobamate or carisoprodol) Intermediates & Fine Chemicals Pharmaceuticals Polyols