ChemicalBook >> CAS DataBase List >>Brequinar
Brequinar
- CAS No.
- 96187-53-0
- Chemical Name:
- Brequinar
- Synonyms
- BPQ;CS-157;Brequinar;Biphenquinate;Brequinar (DUP785);BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.;6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl);6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl;6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid;6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylicaci
- CBNumber:
- CB01178142
- Molecular Formula:
- C23H15F2NO2
- Molecular Weight:
- 375.37
- MDL Number:
- MFCD00866437
- MOL File:
- 96187-53-0.mol
- MSDS File:
- SDS
Last updated:2023-06-08 17:06:34
| Melting point | 355-357℃ (N,N-dimethylformamide water ) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO:25.9(Max Conc. mg/mL);70.0(Max Conc. mM) |
| form | powder to crystal |
| pka | pKa 4.45(H2O t=RT I=0.10) (Uncertain) |
| color | White to Light yellow |
| CAS DataBase Reference | 96187-53-0 |
| FDA UNII | 5XL19F49H6 |
| NCI Drug Dictionary | brequinar |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933.49.7000 |
Brequinar price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B5707 | Brequinar >98.0%(HPLC) | 96187-53-0 | 20mg | $161 | 2024-03-01 | Buy |
| TCI Chemical | B5707 | Brequinar >98.0%(HPLC) | 96187-53-0 | 100mg | $531 | 2024-03-01 | Buy |
| Cayman Chemical | 24445 | Brequinar ≥98% | 96187-53-0 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 24445 | Brequinar ≥98% | 96187-53-0 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 24445 | Brequinar ≥98% | 96187-53-0 | 10mg | $199 | 2024-03-01 | Buy |
Brequinar Chemical Properties,Uses,Production
Uses
Antineoplastic.
Definition
ChEBI: Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, an antineoplastic agent, an antiviral agent, a pyrimidine synthesis inhibitor, an anticoronaviral agent and an antimetabolite. It is a member of biphenyls, a member of monofluorobenzenes, a quinolinemonocarboxylic acid and a monocarboxylic acid. It is a conjugate acid of a brequinar(1-).
Brequinar Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 90)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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96187-53-0(Brequinar)Related Search:
Brequinar
6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid
6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid
6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl
4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-Methyl-
6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
Biphenquinate
6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)
Brequinar (DUP785)
BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.
6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid
CS-157
BPQ
NSC-368390,DHODH,Inhibitor,DUP 785,Brequinar,Virus Protease,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis,SARS coronavirus,inhibit,DUP-785,SARS-CoV,NSC368390
6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylicaci
6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
96187-53-0
C22H13F2NO2
C23H15F2NO2
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