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Ritonavir

Ritonavir
Ritonavir
CAS No.
155213-67-5
Chemical Name:
Ritonavir
Synonyms
Norvi;Norvir;RITONA;ABT-538;A 84538;Ritonavi;RITONAVIR;litonavir;NSC 693184;Abbott 84538
CBNumber:
CB0119429
Molecular Formula:
C37H48N6O5S2
Formula Weight:
720.96
MOL File:
155213-67-5.mol

Ritonavir Properties

Melting point:
120-122°C
Flash point:
2℃
storage temp. 
-20°C Freezer
solubility 
DMSO: soluble10mg/mL (clear solution, warmed)
form 
powder
color 
white to beige
Merck 
14,8238
InChIKey
NCDNCNXCDXHOMX-XGKFQTDJSA-N
CAS DataBase Reference
155213-67-5(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,Xn
Risk Statements  36/38-20/21/22-41
Safety Statements  26-37/39-36/37-39
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS  XA5310000
HS Code  29341000
Hazardous Substances Data 155213-67-5(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Ritonavir price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1734 Ritonavir 155213-67-5 1g $84.4 2018-11-20 Buy
Sigma-Aldrich 1604803 Ritonavir United States Pharmacopeia (USP) Reference Standard 155213-67-5 200mg $348 2018-11-13 Buy
Cayman Chemical 13872 Ritonavir ≥98% 155213-67-5 50mg $187 2018-11-13 Buy
Cayman Chemical 13872 Ritonavir ≥98% 155213-67-5 10mg $44 2018-11-13 Buy
Sigma-Aldrich SML0491 Ritonavir ≥98% (HPLC) 155213-67-5 10mg $60.8 2018-11-13 Buy

Ritonavir Chemical Properties,Uses,Production

Chemical Properties

White or almost white powder.

Uses

Protease inhibitor; antiviral (HIV).

Uses

A selective HIV protease inhibitor

Definition

ChEBI: An L-valine derivative that is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.

brand name

Norvir (Abbott).

Uses

Ritonivir is an HIV protease inhibitor (EC50 = 25 nM) that also inhibits CYP3A4, the primary cytochrome P450 isoform that metabolizes protease inhibitors. Through CYP3A4 inhibition, low doses of ritonivir can reduce the metabolism of concomitantly administered protease inhibitiors, enhancing their bioavailability and efficacy.[Cayman Chemical]

Antimicrobial activity

Ritonavir is active against HIV-1 and, to a lesser extent, HIV-2.

Acquired resistance

At antiretroviral doses resistance is associated with the presence of specific amino acid substitutions in the HIV protease at positions 82 and 84. Concern about the risk for selection of ritonavir resistance when used at a subtherapeutic ‘booster’ dose has so far not been borne out by clinical experience.

Pharmaceutical Applications

A synthetic chemical available for oral use as soft capsules and a liquid formulation. It is now almost exclusively used as a pharmacokinetic enhancer to ‘boost’ the pharmacokinetic properties of HIV protease inhibitors in the treatment of HIV-1 infection in patients over 1 month in age.

Pharmacokinetics

Oral absorption: Not known/available
Cmax 600 mg twice daily: c. 11.2 mg/L
Cmin 600 mg twice daily: c. 3.7 mg/L
Plasma half-life: c. 3–5 h
Volume of distribution: c. 0.3–0.6 L/kg
Plasma protein binding: c. 97%
Absorption and distribution
Fasting and high-fat meals had no appreciable effect on oral absorption. It penetrates poorly into the CNS. The semen:plasma ratio is <0.04. It is distributed into breast milk.
Metabolism and excretion
Four oxidized metabolites have been identified, the major of which retains antiretroviral activity. Around 11% of the dose is excreted in urine, 4% as unchanged drug. The remainder is found in feces. Metabolites are eliminated primarily via the feces.
No dose adjustment is recommended in mild to moderate hepatic impairment. It should not be given to patients with severe hepatic impairment, nor should it be given as a pharmacokinetic enhancer to patients with decompensated liver disease.

Clinical Use

Treatment of HIV infection in adults and children >1 month old (in combination with other antiretroviral agents)

Side effects

Full (antiretroviral) doses are associated with nausea, vomiting, diarrhea and fatigue in >20% of subjects. The degree to which ritonavir at low dose is associated with specific adverse events is uncertain. In HIV-negative healthy volunteers given ‘booster’ doses of 100 mg every 12 h, the concentration of total cholesterol, low-density cholesterol and triglycerides all increased, and the concentration of high-density cholesterol concentration fell.

Ritonavir Preparation Products And Raw materials

Raw materials

Preparation Products


Ritonavir Suppliers

Global( 262)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 955 58
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 1954 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 4525 58
Jinan Tenglong Chemical Co.,Ltd
Whatsapp:+8615563263311 Skype:live:smions7080
smions7080@gmail.com CHINA 778 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 295 58

View Lastest Price from Ritonavir manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-15 Ritonavir
155213-67-5
US $1.00 / KG 1G 98% 100KG career henan chemical co

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