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Medical uses
Ritonavir structure
Chemical Name:
Norvi;Norvir;RITONA;CS-477;ABT-538;A 84538;Ritonavi;RITONAVIR;litonavir;NSC 693184
Molecular Formula:
Formula Weight:
MOL File:

Ritonavir Properties

Melting point:
Boiling point:
947.0±65.0 °C(Predicted)
1.239±0.06 g/cm3(Predicted)
Flash point:
storage temp. 
room temp
DMSO: soluble10mg/mL (clear solution, warmed)
white to beige
Water Solubility 
CAS DataBase Reference
155213-67-5(CAS DataBase Reference)
NCI Dictionary of Cancer Terms
Norvir; ritonavir
NCI Drug Dictionary
ATC code
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H225-H302+H312+H332-H319
Precautionary statements  P210-P280-P305+P351+P338-P261-P301+P312+P330-P302+P352+P312-P304+P340+P312
Hazard Codes  Xi,Xn
Risk Statements  36/38-20/21/22-41
Safety Statements  26-37/39-36/37-39
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS  XA5310000
HS Code  29341000

Ritonavir price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000706 Ritonavir for peak identification European Pharmacopoeia (EP) Reference Standard 155213-67-5 $190 2021-12-16 Buy
Sigma-Aldrich 1604803 Ritonavir United States Pharmacopeia (USP) Reference Standard 155213-67-5 200mg $366 2021-12-16 Buy
Sigma-Aldrich PHR1734 Ritonavir 155213-67-5 1g $92.1 2021-12-16 Buy
Cayman Chemical 13872 Ritonavir ≥98% 155213-67-5 50mg $187 2021-12-16 Buy
Cayman Chemical 13872 Ritonavir ≥98% 155213-67-5 10mg $44 2021-12-16 Buy

Ritonavir Chemical Properties,Uses,Production

Medical uses

Ritonavir is indicated in combination with other antiretroviral agents for the treatment of HIV-1-infected patients.


Ritonavir is an HIV protease inhibitor. It inhibits recombinant HIV-1 protease by 79% when used at a concentration of 0.5 nM. It inhibits HIV-13B-induced cell death in MT-4 human T cell leukemia cells (EC50 = 25 nM) as well as cell death induced by HIV-1LAI, HIV-2ROD, and HIV-2EHO in human MT-2 cells (IC50s = 0.045, 0.13, and 0.24 μM, respectively). Ritonavir also inhibits the cytochrome P450 (CYP) isoform CYP3A (IC50 = 0.14 μM). It inhibits CYP-mediated oxidative metabolism of the HIV protease inhibitors saquinavir (Item No. 9001893), indinavir (Item No. 15150), nelfinavir (Item No. 15144), and amprenavir (Item No. 15369) in rat and human liver microsomes in a concentration-dependent manner. Ritonavir (10 mg/kg) also prevents decreases in plasma levels of these four compounds in rats. Formulations containing ritonavir have been used in the treatment of HIV-1 infection.


Norvir was launched in Germany, the UK and US for treatment of advanced HIV in combination with antiretroviral nucleoside analogs in a record 72 days by the FDA. It is an inhibitor of HIV aspartic protease which is critical in the processing of a propeptide into the gag, gag-pol gene products and the protease itself. This inhibition results in the release of non-infectous immature virus particles. It is greater than 500-fold more selective for viral aspartic protease than the human version, has good oral bioavailability and may increase the bioavailability of other protease inhibitors. Ritonavir was able to increase the CD4 and CD8 lymphocyte count as well as reduce viral RNA. It is more potent than saqunavir and comparible in potency to zidovudine and lamivudine.Ritonavir.jpg

Chemical Properties

White or almost white powder.


Abbott (USA)


Protease inhibitor; antiviral (HIV).


Ritonivir is an HIV protease inhibitor (EC50 = 25 nM) that also inhibits CYP3A4, the primary cytochrome P450 isoform that metabolizes protease inhibitors. Through CYP3A4 inhibition, low doses of ritonivir can reduce the metabolism of concomitantly administered protease inhibitiors, enhancing their bioavailability and efficacy.[Cayman Chemical]


A selective HIV protease inhibitor


ChEBI: An L-valine derivative that is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.


Although ritonavir (Norvir) is a potent inhibitor of HIV-1 and HIV-2 protease, it is not well tolerated in higher doses. It is mainly used in low doses to increase blood levels of other protease inhibitors and to extend their dosing interval. Ritonavir is more commonly associated with gastrointestinal side effects, altered taste sensation, paresthesias, and hypertriglyceridemia than are other protease inhibitors. Pancreatitis may occur in the presence or absence of hypertriglyceridemia.

brand name

Norvir (Abbott).

Antimicrobial activity

Ritonavir is active against HIV-1 and, to a lesser extent, HIV-2.

Acquired resistance

At antiretroviral doses resistance is associated with the presence of specific amino acid substitutions in the HIV protease at positions 82 and 84. Concern about the risk for selection of ritonavir resistance when used at a subtherapeutic ‘booster’ dose has so far not been borne out by clinical experience.

General Description

Ritonavir belongs to the group of protease inhibitors, which block the part of HIV called protease. Its mode of action involves binding to the protease active site and inhibiting the activity of the enzyme.

Pharmaceutical Applications

A synthetic chemical available for oral use as soft capsules and a liquid formulation. It is now almost exclusively used as a pharmacokinetic enhancer to ‘boost’ the pharmacokinetic properties of HIV protease inhibitors in the treatment of HIV-1 infection in patients over 1 month in age.

Mechanism of action

Because of the strong CYP450-inhibiting effects of ritonavir, the drug has found value when used in fixed-dosage combinations with other PIs to block their metabolism and act as a booster for these drugs (lopinavir/ritonavir and tipranavir/ritonavir). In these cases, ritonavir is used in a subtherapeutic dose but boosts the effectiveness of the coadministered drug. The utilization of ritonavir in a therapeutic dose for treating HIV infections appears to be decreasing, but its utilization as a booster drug is finding favor.


Oral absorption: Not known/available
Cmax 600 mg twice daily: c. 11.2 mg/L
Cmin 600 mg twice daily: c. 3.7 mg/L
Plasma half-life: c. 3–5 h
Volume of distribution: c. 0.3–0.6 L/kg
Plasma protein binding: c. 97%
Absorption and distribution
Fasting and high-fat meals had no appreciable effect on oral absorption. It penetrates poorly into the CNS. The semen:plasma ratio is <0.04. It is distributed into breast milk.
Metabolism and excretion
Four oxidized metabolites have been identified, the major of which retains antiretroviral activity. Around 11% of the dose is excreted in urine, 4% as unchanged drug. The remainder is found in feces. Metabolites are eliminated primarily via the feces.
No dose adjustment is recommended in mild to moderate hepatic impairment. It should not be given to patients with severe hepatic impairment, nor should it be given as a pharmacokinetic enhancer to patients with decompensated liver disease.

Clinical Use

Treatment of HIV infection in adults and children >1 month old (in combination with other antiretroviral agents)

Side effects

Full (antiretroviral) doses are associated with nausea, vomiting, diarrhea and fatigue in >20% of subjects. The degree to which ritonavir at low dose is associated with specific adverse events is uncertain. In HIV-negative healthy volunteers given ‘booster’ doses of 100 mg every 12 h, the concentration of total cholesterol, low-density cholesterol and triglycerides all increased, and the concentration of high-density cholesterol concentration fell.

Ritonavir Preparation Products And Raw materials

Raw materials

Preparation Products

Ritonavir Suppliers

Global( 435)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Biolang Biotechnology Co., Ltd.
+8613397199602 +86-133-9719-9602
+8613397199602 China 589 58
0086-13720134139 CHINA 968 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715 CHINA 3004 58
ShenZhen Ipure Biology import and export company co.,ltd
18071025641 18071025641 CHINA 11336 58
Changsha Chemoway Imp and Exp Co.,Ltd
+86 0731-84372166 CHINA 233 58
Hebei Senko Biotechnology Co., Ltd.
0086-133 3137 7233 CHINA 289 58
Shanghai Longyu Biotechnology Co., Ltd.
+86 15821988213 China 2514 58
Hangzhou Proserre Chemical Co.,Ltd.
+86-571-86088112 China 1080 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 20012 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 China 22607 55

Related articles

View Lastest Price from Ritonavir manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-27 Ritonavir
US $26.99 / KG 1KG 99% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd
2022-01-27 RITONAVIR
US $1.00 / g 1g 99.99% 20t Jinan Jianfeng Chemical Co., Ltd
2022-01-26 Ritonavir
US $10.00 / KG/Tin 1KG 99% 10Tons Isonicotinic acid Hebei Senko Biotechnology Co., Ltd.

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