ChemicalBook >> CAS DataBase List >>(-)-ANABASINE

(-)-ANABASINE

(-)-ANABASINE structure

CAS No.: 494-52-0

Chemical Name:: (-)-ANABASINE

Synonyms: Anabasin;Anabazin;ANOBASINE;ANABASINE;Neonikoti;Neonikotin;NEONICOTINE;L-ANABASINE;(-)-anabasin;(-)-ANABASINE

CBNumber:: CB0119964

Molecular Formula:: C10H14N2

Molecular Weight:: 162.23

MDL Number:: MFCD00871391

MOL File:: 494-52-0.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:10

Request For Quotation

(-)-ANABASINE Properties

Melting point	9°C
Boiling point	270-272°C
alpha	D20 -83.1°
Density	1,0455 g/cm³
refractive index	1.5430
Flash point	93°C
storage temp.	2-8°C
solubility	DMSO : 100 mg/mL (616.41 mM)
pka	8.98±0.10(Predicted)
form	Liquid
Merck	14,619
BRN	82637
CAS DataBase Reference	494-52-0(CAS DataBase Reference)
FDA UNII	LMS11II2LO
NIST Chemistry Reference	Pyridine, 3-(2-piperidinyl)-, (S)-(494-52-0)
EPA Substance Registry System	Anabasine (494-52-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09,GHS06
Signal word	Danger
Hazard statements	H310-H411-H300
Precautionary statements	P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501
Hazard Codes	T
Risk Statements	27/28-51/53-23/24/25
Safety Statements	28-36/37-45-61-36/37/39-28A
RIDADR	3140
RTECS	BV4375000
HazardClass	6.1
PackingGroup	I
HS Code	29333990
Toxicity	LDLo orl-dog: 50 mg/kg JPETAB 48,95,33

(-)-ANABASINE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A637170	(S)-Anabasine,>98%ee	494-52-0	100mg	$350	2021-12-16	Buy
TRC	A637170	(S)-Anabasine,>98%ee	494-52-0	500mg	$1455	2021-12-16	Buy
American Custom Chemicals Corporation	HBL0000006	(-)-ANABASINE 95.00%	494-52-0	1G	$1593.9	2021-12-16	Buy
Activate Scientific	AS7078-A	(S)-3-(Piperidin-2-yl)pyridine 95+% ee	494-52-0	5G	$2356	2021-12-16	Buy
Biosynth Carbosynth	FA17898	(S)-Anabasine	494-52-0	500mg	$675	2021-12-16	Buy

Product number	Packaging	Price	Buy
A637170	100mg	$350	Buy
A637170	500mg	$1455	Buy
HBL0000006	1G	$1593.9	Buy
AS7078-A	5G	$2356	Buy
FA17898	500mg	$675	Buy

(-)-ANABASINE Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Oil

Uses

(S)-ANABASINE is used as a kind of Nicotinic receptor agonist.

Uses

Anabasine occurs in the tobacco speciesNicotiana glauca, Anabasis aphylla L.,Chenopodiaceae, and Solanaceae. It is usedas an insecticide and as a metal anticorrosiveagent.

Definition

ChEBI: The (S)-enantiomer of anabasine.

Health Hazard

The acute toxic symptoms include increasedsalivation, confusion, disturbed vision, photophobia,nausea, vomiting, diarrhea, respiratorydistress, and convulsions. It causesrespiratory muscle stimulation similar to thatcaused by lobeline. An oral lethal dose indogs is 50 mg/kg. A subcutaneous lethaldose in guinea pigs is 10 mg/kg.

Biological Activity

Anabasine ((S)-Anabasine) is an alkaloid, a component of tobacco. Anabasine is a botanical insecticide that acts as a pan-agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization in TE671 cells endogenously expressing human myogenic nAChRs (EC50=0.7 μM).

Safety Profile

Poison by ingestion,subcutaneous, and intravenous routes. Moderately toxicby skin contact. An experimental teratogen. Insecticide.Acute and subacute toxicity: increased salivation, vertigo,confusion, disturbed vision and hearing, photophobia,cold ext

in vivo

Anabasine significantly reverses the impairment at the 0.2 mg/kg (p<0.05) and 2 mg/kg doses (p<0.025). Anabasine does not have any significant effects on response latency when administered alone. The 0.06 mg/kg Anabasine dose, in fact, significantly (p<0.05) exacerbates the dizocilpine-induced impairment. None of these Anabasine doses affects choice accuracy on their own. Individual dose comparisons show that the 0.06 mg/kg Anabasine dose plus dizocilpine (6.7±2.6) causes a significant (p<0.05) increase in non-response trials compare with dizocilpine alone (2.1±0.8).

(-)-ANABASINE synthesis

Synthesis of (-)-ANABASINE from 3-Pyridinecarboxaldehyde

(-)-ANABASINE Preparation Products And Raw materials

Raw materials

(R)-3-(PIPERIDIN-2-YL)PYRIDINE 5-OXO-5-(3-PYRIDYL)VALERIC ACID N-tert-Butoxycarbonylanabasine 3-Pyridinecarboxaldehyde

Preparation Products

(R,S)-N-NITROSOANABASINE (S)-3-(Piperidin-2-yl)pyrdine, chlorohydrate (1:1)

(-)-ANABASINE Suppliers

Global( 126)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Henan Alfa Chemical Co., Ltd	+8618339805032	alfa4@alfachem.cn	China	12756	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19994	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
Hubei Jusheng Technology Co.,Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Henan Alfa Chemical Co., Ltd	58
Labnetwork lnc.	58
sgtlifesciences pvt ltd	58
Alfa Chemistry	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58

View Lastest Price from (-)-ANABASINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-01-12	Anabasine 494-52-0	US $1.00-90.00 / KG	0.5KG	>99%	20tons	Anhui Rencheng Technology Co., Ltd
2021-08-11	(-)-ANABASINE 494-52-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-03-06	Anabasine 494-52-0	US $8.00 / KG	1g	≥98%	kg--tons	Career Henan Chemical Co

Anabasine
494-52-0
US $1.00-90.00 / KG
>99%
Anhui Rencheng Technology Co., Ltd

(-)-ANABASINE
494-52-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Anabasine
494-52-0
US $8.00 / KG
≥98%
Career Henan Chemical Co

494-52-0((-)-ANABASINE)Related Search:

Protionamide Sulfoxide (-)-ANABASINE AKOS 213-73 (S)-3-(3,4,5,6-TETRAHYDRO-2H-[2,3']BIPYRIDINYL-1-YL)-PROPIONIC ACID METHYL ESTER (R,S)-N-NITROSOANABASINE

4-OXO-4-(S)-3,4,5,6-TETRAHYDRO-2H-[2,3']BIPYRIDINYL-1-YL-BUTYRIC ACID (+/-)-ANABASINE DIPICRATE (-)-ANABASINE N-Methylanabasine 4-METHOXY-3-[(S)-1-(3,4,5,6-TETRAHYDRO-2H-[2,3']BIPYRIDINYL-1-YL)METHYL]-BENZALDEHYDE

(S)-2-(3,4,5,6-TETRAHYDRO-2H-[2,3']BIPYRIDINYL-1-YL)-ETHANOL (+)-Anabasinehydrochloride AKOS 213-74 3-[(2S)-PIPERIDIN-2-YL]PYRIDINE HYDROCHLORIDE ANABASINE SULFATE

1of3

(-)-anabasin (s)-3-(2-piperidinyl)pyridine ANOBASINE L(-)-Anabasine,90% (2S)-3-(2-Piperidinyl)-pyridine (-)-2-(3'-Pyridyl)piperidine L(-)-Anabasine, 90% 500MG (S)-(-)-2-(3-PYRIDYL)PIPERIDINE (S)-1,2,3,4,5,6-HEXAHYDRO-[2,3']BIPYRIDINYL NEONICOTINE L(-)-NEONICOTINE L(-)-ANABASINE L-ANABASINE 2-(3-PYRIDYL)PIPERIDINE (-)-ANABASINE ANABASINE 3-(2S)-2-Piperidinyl-pyridine Neonikoti 2-(3-pyridyl)-piperidin 3-(2-Piperidinyl)pyridine 3-(2-piperidyl)-pyridin Anabasin Anabazin l-3-(2’-piperidyl)pyridine L-3-(2'-Piperidyl)pyridine Neonikotin Piperidine, 2-(3-pyridyl)- Pyridine, 3-(2-piperidyl)- pyridine,3-(2-pyridyl)piperidine S-(-)-Anabasine (S)-3-(Piperidin-2-yl)pyridine+ PYRIDINE,3-(2S)-2-PIPERIDINYL-, Nicotine USP RC G 3-((S)-piperidin-2-yl)pyridine Nicotine Related Compound G (20 mg) (S)-Anabasine, > 70% ee DISCONTINUED. Please see A637170 (S)-Anabasine, > 98% ee Nicotine Impurity G Nicotine USP Related Compound G 3-[(2S)-piperidin-2-yl]pyridine (anabasine) (S)-Snabasine Rizatriptan Impurity 3-d6 Benzoate Salt（Rizatriptan EP Impurity C-d6 Benzoate Salt） 494-52-0 Aromatics Compounds Aromatics Chiral Reagents Nicotine Derivatives