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HATU

CAS No.
148893-10-1
Chemical Name:
HATU
Synonyms
1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate;2-(7-AZA-1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate(V);O-(7-AZABENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetraMethyluroniuM hexafluorophosphate(V);[bis(dimethylamino)methylidene]({3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl})oxidanium;1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, ChemDoseTM tablets;2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium;1-[BIS(DIMETHYLAMINO)METHYLENE]-1 H-1,2,3-TRIAZOLO(4,5-B) PYRIDINIUM 3-OXIDE HEXAFLUOROPHOSPHATE;N-[(Dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-N-methylmethylaminium hexafluorophosphate
CBNumber:
CB0122630
Molecular Formula:
C10H15F6N6OP
Molecular Weight:
380.24
MDL Number:
MFCD00274639
MOL File:
148893-10-1.mol
Last updated:2023-10-25 16:06:20

HATU Properties

Melting point 183-188 °C (dec.)
RTECS XZ5633000
storage temp. 2-8°C
solubility >16mg/mL in DMSO
form powder to crystaline
color White to Almost white
Water Solubility Soluble in acetonitrile. Insoluble in water.
InChI InChI=1S/C10H15N6O.F6P/c1-13(2)10(14(3)4)15-8-6-5-7-11-9(8)16(17)12-15;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1
InChIKey KZAWCZZRROLLDL-UHFFFAOYSA-N
SMILES [P+5]([F-])([F-])([F-])([F-])([F-])[F-].C(=[N+]1/N=N(=O)C2=NC=CC=C/12)(\N(C)C)/N(C)C
CAS DataBase Reference 148893-10-1(CAS DataBase Reference)
FDA UNII B93RIH1T7E
EPA Substance Registry System 1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, hexafluorophosphate(1-), 3-oxide (148893-10-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P272-P280-P284-P302+P352-P304+P340+P312
Hazard Codes  Xi,Xn,E
Risk Statements  36/37/38-20/21/22-2
Safety Statements  26-37/39-36/37-36-35
RIDADR  1325
WGK Germany  3
10-21
HazardClass  4.1
PackingGroup 
HS Code  29339999
NFPA 704
2
2 0

HATU price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 445460 HATU 97% 148893-10-1 1g $64.5 2024-03-01 Buy
Sigma-Aldrich 8.51013 HATU Novabiochem? 148893-10-1 25g $518 2024-03-01 Buy
Sigma-Aldrich 8.51013 HATU Novabiochem? 148893-10-1 100g $742 2024-03-01 Buy
Sigma-Aldrich 445460 HATU 97% 148893-10-1 5g $119 2024-03-01 Buy
TCI Chemical A1797 O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate >98.0%(HPLC) 148893-10-1 5g $111 2024-03-01 Buy
Product number Packaging Price Buy
445460 1g $64.5 Buy
8.51013 25g $518 Buy
8.51013 100g $742 Buy
445460 5g $119 Buy
A1797 5g $111 Buy

HATU Chemical Properties,Uses,Production

Description

HATU, first prepared by Louis A. Carpino in 1993, is widely used in carboxylic acid amidation reactions. It acts as a facilitator of amide bond generation by activating the carboxyl group.

Chemical Properties

White crystalline to off-white powder

Uses

HATU[148893-10-1] is a coupling reagent and used as an additive in peptide synthesis. It is also involved efficiently to speed up the coupling process and reduces the loss of chiral integrity.
Reagent for: Synthesis of Aurora A kinase inhibitors, HPLC assay to determine D- and L- acid enantiomers in human plasma, Amide bond formation reactions.
Catalyst for: Selective acylation, Selecocyclization-oxidation deselenation sequence.

Synthesis

The synthesis of HATU is as follows:The resulting residue treated with 2-Methoxycarbonylamino-3-methyl-butyric acid (60 mg, 0.343 mmol) and HATU (130 mg, 0.343 mmol), suspended in DMF (3 mL) and cooled to 0° C. DIPEA (0.272 mL, 1.56 mmol) was added dropwise. After stirring for 4 h, NaOH (5M in H2O, 0.300 mL, 1.5 mmol) was added. This mixture was stirred for 3 h then diluted with EtOAc and washed with 1 M LiOH (2*) then brine. The organic phase was dried over MgSO4, filtered and concentrated. The crude residue was then purified by HPLC to afford the title compound (53 mg, 44%).

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HATU Preparation Products And Raw materials

Global( 667)Suppliers
Supplier Tel Email Country ProdList Advantage
Allfluoro pharmaceutical co. ltd.
021-26137118 +8615821363818 sales@allfluoro.com China 5791 58
Zhengzhou Anbu Chem Co.,Ltd
+8615988602810 sales@anbuchem.com China 2999 58
LEAP CHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 24738 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14770 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9359 55

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View Lastest Price from HATU manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
HATU pictures 2023-09-15 HATU
148893-10-1
US $20.00 / g 1g 99.99% 1000 KG Lihe Pharm Technology(Wuhan)Co.,Ltd
HATU pictures 2023-08-05 HATU
148893-10-1
US $100.00 / kg 1kg 99% 1000tons Henan Bao Enluo International TradeCo.,LTD
HATU pictures 2023-06-03 HATU
148893-10-1
US $0.00 / KG 1KG 99% 1000 kg Hebei Mojin Biotechnology Co., Ltd
  • HATU pictures
  • HATU
    148893-10-1
  • US $20.00 / g
  • 99.99%
  • Lihe Pharm Technology(Wuhan)Co.,Ltd
  • HATU pictures
  • HATU
    148893-10-1
  • US $100.00 / kg
  • 99%
  • Henan Bao Enluo International TradeCo.,LTD
  • HATU pictures
  • HATU
    148893-10-1
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
HATU 2-(7-AZOBENZOTRIAZOLYL-1-OXY)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE 99% 2-(7-AZA-1H-BENZOTRIAZOLE-1-YL)-1,1,3,3- TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE (HATU) O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethylur O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N',N'-TE& O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE (HATU) O-(7-AZABENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE (HATU) O-(7-Azabenzotriazol-1-yl)-N,N,Nzzhlxy,Nzzhlxy- tetramethyluronium hexafluorophosphate (HATU) HATU 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetraMethyluroniuM hexafluorophosphate 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetraMethy O-(7-Azabenzotriazol-1-yl)-N,N,N',N`-tetraMethyluroniuM N,N,N',N'-TetD23-RAMethyl-O-(7-azabenzotriazol-1-yl)uroniuM hexafluorophosphate N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5,b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide impregnated tablets 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate impregnated tablets 2-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate HATU >=98.0% (CHN) O-(7-AZABENZOTRIAZOL-1-YL)URONIUM HEXAFLUORO-PHOSPHATE O-(7-AZABENZOTRIAZOLE-1-YL)-N, N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE N,N,N',N'-TETRAMETHYL-O-(7-AZABENZOTRIAZOL-1-YL)URONIUM HEXAFLUOROPHOSPATE N,N,N',N'-TETRAMETHYL-O-(7-AZABENZOTRIAZOL-1-YL)URONIUM HEXAFLUOROPHOSPHATE azabenzotriazolyl tetramethyluronium hexafluorophosphate HATU, N,N,Nμ,Nμ-Tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate HATU impregnated tablets, N,N,Nμ,Nμ-Tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate impregnated tablets, ChemDose(R) O-(7-Azabenzotriazol-1-yl)-N,N,Nμ,Nμ-tetramethyluronium hexafluorophosphate tablets, O-(7-Azabenzotriazol-1-yl)-N,N,Nμ,Nμ-tetramethyluronium hexafluorophosphate impregnated tablets O-(7-Azabenzotriazol-1-yl)-N,N,Nμ,Nμ-tetramethyluronium hexafluorophosphate, ChemDose(R) tablets O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 99% O-(7-Azabenzotriazol-1-yl)-N,N,N',N'- tetramethyluronium hexaflu HATU,99% O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyl O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl uranium hexafluorophosphate HATU(o-(7-Azabenzotriazol-1-yl)uroniumhexafluoro-phosphate) O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate ,98% O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate ,99% O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate,N,N,N′,N′-Tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate, HATU O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, ChemDose tablets,N,N,N′,N′-Tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate impregnated tablets, O-(7-Aza O-(7-Azabenzotriazol [dimethylamino(triazolo[4,5-b]pyridin-3-yloxy)methylidene]-dimethylazanium 2-(7-Aza-1H-benzotriazole-1-yl)-1 3-tetraMethyluroniuM hexafluorophosphate (HATU) HATU O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N'',N''-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLUROINIUM HEXAFLUOROPHOSPHATE o-(7-azabenzotriazol-1-yl)-n,n,n’,n’-te-tramethyluroniumpf6 HATU 2-(1H-7-AZABENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYL URONIUM HEXAFLUOROPHOSPHATE METHANAMINIUM 1-[(dimethylamino)(dimethyliminiumyl)methyl]-3-oxo-1H,2H,3H-3λ?-[1,2,3]triazolo[5,4-b]pyridin-3-ylium-2-ide O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 99%, for synthesis O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate > HATU O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate,99% 2-(7-Aza-1H-benzotriazoL e-1-yL HATU USP/EP/BP HATU CAS 148893 10 1 HBTU [ 94790-37-1 o-(7-Azabenzotriazol-1-yl)-N,N,N',N'-te-tramethyluronium hex... [Dimethylamino(triazolo[4,5-b]pyridin-3-yloxy)methylene]-dimethyl-ammonium hexafluorophosphate HATU extrapure, 98% O-(7- 1-[BIS(DIMETHYLAMINO)METHYLENE]-1 H-1,2,3-TRIAZOLO(4,5-B) PYRIDINIUM 3-OXIDE HEXAFLUOROPHOSPHATE 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetraMethyluroniuM hexafluorophosphate(V)