ChemicalBook >> CAS DataBase List >>(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid

CAS No.
547-98-8
Chemical Name:
(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid
Synonyms
THCA;Coprocholic acid;Trihydroxycholestanoic acid;3α,7α,12α-Trihydroxycoprostanic Acid;3α,7α,12α-Trihydroxycoprostanoic acid;3,7,12-trihydroxycholestan-26-oic acid;3α,7α,12α-trihydroxy cholestanoic acid;3α,7α,12α-Trihydroxy-5β-cholestanoic acid;3α,7α,12α-Trihydroxy-5β-cholestan-27-oic acid;3α,7α,12α-Trihydroxy-5β-cholestan-26-oic acid
CBNumber:
CB01235764
Molecular Formula:
C27H46O5
Molecular Weight:
450.65
MDL Number:
MOL File:
547-98-8.mol
Last updated:2023-06-08 09:03:09

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Properties

storage temp. -20°C
solubility Chloroform (Slightly, Heated), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form Solid
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 26098 Trihydroxycholestanoic Acid 547-98-8 500μg $68 2024-03-01 Buy
Cayman Chemical 26098 Trihydroxycholestanoic Acid 547-98-8 5mg $302 2024-03-01 Buy
Cayman Chemical 26098 Trihydroxycholestanoic Acid 547-98-8 1mg $130 2024-03-01 Buy
AK Scientific 8684CA 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oicacid 547-98-8 1mg $241 2021-12-16 Buy
American Custom Chemicals Corporation LIP0002925 3-ALPHA-7-ALPHA-12-ALPHA-TRIHYDROXYCHOLESTANOIC ACID 95.00% 547-98-8 5MG $502.14 2021-12-16 Buy
Product number Packaging Price Buy
26098 500μg $68 Buy
26098 5mg $302 Buy
26098 1mg $130 Buy
8684CA 1mg $241 Buy
LIP0002925 5MG $502.14 Buy

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Chemical Properties,Uses,Production

Uses

3α,7α,12α-Trihydroxycoprostanic Acid is a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α,12α-Trihydroxycoprostanic Acid.

Definition

ChEBI: A steroid acid that is 5beta-cholestan-26-oic acid which is substituted by hydroxy groups as the 3alpha, 7alpha, and 12alpha positions.

General Description

Trihydroxycholestanoic acid (THCA) is an oxidative metabolite of cholesterol and a precursor to bile acids. Very long-chain acyl-CoA synthetase (VLCS) associated with endoplasmic reticulum and peroxisomes activates THCA, the C27 bile acid intermediate.

Biochem/physiol Actions

Trihydroxycholestanoic acid (THCA) and dihydroxycholestanoic (DHCA) accumulation is observed in Zellweger syndrome and cholestatic liver disease. The synthesis of (25R)-isomer of DHCA and THCA is favored by mitochondrial 27-hydroxylase.

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Suppliers

Global( 11)Suppliers
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Alfa Chemistry
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ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396 sales@chem-strong.com China 18021 56
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8732 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 28070 58
SHANGHAI ZZBIO CO., LTD. 15102117276 19921389125 tech@zzbioco.com China 12064 58

547-98-8((3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid)Related Search:

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid 3α,7α,12α-Trihydroxy-5β-cholestan-26-oic acid 3α,7α,12α-Trihydroxy-5β-cholestan-27-oic acid 3α,7α,12α-Trihydroxy-5β-cholestanoic acid 3α,7α,12α-Trihydroxycoprostanoic acid THCA Trihydroxycholestanoic acid 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid Coprocholic acid 3,7,12-trihydroxycholestan-26-oic acid Cholestan-26-oic acid, 3,7,12-trihydroxy-, (3α,5β,7α,12α)- 3α,7α,12α-Trihydroxycoprostanic Acid 3α,7α,12α-trihydroxy cholestanoic acid 547-98-8