(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid
- CAS No.
- 547-98-8
- Chemical Name:
- (3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid
- Synonyms
- THCA;Coprocholic acid;Trihydroxycholestanoic acid;3α,7α,12α-Trihydroxycoprostanic Acid;3α,7α,12α-Trihydroxycoprostanoic acid;3,7,12-trihydroxycholestan-26-oic acid;3α,7α,12α-trihydroxy cholestanoic acid;3α,7α,12α-Trihydroxy-5β-cholestanoic acid;3α,7α,12α-Trihydroxy-5β-cholestan-27-oic acid;3α,7α,12α-Trihydroxy-5β-cholestan-26-oic acid
- CBNumber:
- CB01235764
- Molecular Formula:
- C27H46O5
- Molecular Weight:
- 450.65
- MDL Number:
- MOL File:
- 547-98-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
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(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26098 | Trihydroxycholestanoic Acid | 547-98-8 | 500μg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 26098 | Trihydroxycholestanoic Acid | 547-98-8 | 5mg | $302 | 2024-03-01 | Buy |
| Cayman Chemical | 26098 | Trihydroxycholestanoic Acid | 547-98-8 | 1mg | $130 | 2024-03-01 | Buy |
| AK Scientific | 8684CA | 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oicacid | 547-98-8 | 1mg | $241 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | LIP0002925 | 3-ALPHA-7-ALPHA-12-ALPHA-TRIHYDROXYCHOLESTANOIC ACID 95.00% | 547-98-8 | 5MG | $502.14 | 2021-12-16 | Buy |
(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Chemical Properties,Uses,Production
Uses
3α,7α,12α-Trihydroxycoprostanic Acid is a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α,12α-Trihydroxycoprostanic Acid.
Definition
ChEBI: A steroid acid that is 5beta-cholestan-26-oic acid which is substituted by hydroxy groups as the 3alpha, 7alpha, and 12alpha positions.
General Description
Trihydroxycholestanoic acid (THCA) is an oxidative metabolite of cholesterol and a precursor to bile acids. Very long-chain acyl-CoA synthetase (VLCS) associated with endoplasmic reticulum and peroxisomes activates THCA, the C27 bile acid intermediate.
Biochem/physiol Actions
Trihydroxycholestanoic acid (THCA) and dihydroxycholestanoic (DHCA) accumulation is observed in Zellweger syndrome and cholestatic liver disease. The synthesis of (25R)-isomer of DHCA and THCA is favored by mitochondrial 27-hydroxylase.
(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18021 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8732 | 58 |
| SHANGHAI ZZBIO CO., LTD. | 15102117276 19921389125 | tech@zzbioco.com | China | 12064 | 58 |