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(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER

(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER structure

CAS No.: 165727-45-7

Chemical Name:: (1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER

Synonyms: (3S)-3-(tert-Butoxycarbonyl)amino-1-chloro-4-phenyl-(2S)-butanol;(1S, 2S)-[3-Chloro-2-hydroxy-1-(phenylmethyl)-;(3s)-1-Chloro-3-(Boc-amino)-4-Phenyl-2-Butanol;(2S,3S)-N-t-butyloxycarbonyl-3-amino-1-chloro-2-phenylbutanol;2S,3S-(1-Chloro-3-(t-butoxycarbonylamino)-4-phenyl-butan-2-ol);(1S, 2S)-(1-benzyl-3-chloro-2-hydroxy-propyl)-carbamic acid ...;(2S,3S)-(-)-3-T-BUTOXYCARBONYLAMINO-1-CHLORO-4-PHENYL-BUTAN-2-OL;Tert-Butyl (2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-ylcarbamate;(2S,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane;(2S，3S)-N-tert-Butoxycarbonyl-3-amino-1-chloro-2-hydroxy-4-phenylbutane

CBNumber:: CB0127655

Molecular Formula:: C15H22ClNO3

Molecular Weight:: 299.79

MDL Number:: MFCD02183480

MOL File:: 165727-45-7.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:44

Product description	Number	Pack Size	Price
TERT-BUTYL ((2S,3S)-4-CHLORO-3-HYDROXY-1-PHENYLBUTAN-2-YL)CARBAMATE 97%	68144	1G	$23
TERT-BUTYL ((2S,3S)-4-CHLORO-3-HYDROXY-1-PHENYLBUTAN-2-YL)CARBAMATE 97%	68144	5G	$33
tert-Butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate 95+%	B58440	250mg	$22
tert-Butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate 95+%	B58440	1g	$26
tert-Butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate 95+%	B58440	5g	$28
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(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER Properties

Boiling point	460.5±45.0 °C(Predicted)
Density	1.153±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	11.92±0.46(Predicted)
Appearance	White to off-white Solid
optical activity	Consistent with structure
CAS DataBase Reference	165727-45-7(CAS DataBase Reference)
FDA UNII	KAW3VT1CPJ

(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	68144	TERT-BUTYL ((2S,3S)-4-CHLORO-3-HYDROXY-1-PHENYLBUTAN-2-YL)CARBAMATE 97%	165727-45-7	1G	$23	2026-04-30	Buy
AstaTech	68144	TERT-BUTYL ((2S,3S)-4-CHLORO-3-HYDROXY-1-PHENYLBUTAN-2-YL)CARBAMATE 97%	165727-45-7	5G	$33	2026-04-30	Buy
Synthonix	B58440	tert-Butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate 95+%	165727-45-7	250mg	$22	2026-05-06	Buy
Synthonix	B58440	tert-Butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate 95+%	165727-45-7	1g	$26	2026-05-06	Buy
Synthonix	B58440	tert-Butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate 95+%	165727-45-7	5g	$28	2026-05-06	Buy

Product number	Packaging	Price	Buy
68144	1G	$23	Buy
68144	5G	$33	Buy
B58440	250mg	$22	Buy
B58440	1g	$26	Buy
B58440	5g	$28	Buy

(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production

Application

(1S,2S)-(1-benzyl-3-chloro-2-hydroxypropyl) tert-butyl carbamate is mainly used as an intermediate in the active pharmaceutical ingredient darunavir, primarily in laboratory research and development processes and pharmaceutical and chemical production processes.

Synthesis

(3S)-3-(tert-Butoxycarbonyl)amino-1-chloro-4-phenyl-2-butanone

102123-74-0

(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER

165727-45-7

Using (3S)-3-(tert-butoxycarbonyl)amino-1-chloro-4-phenyl-2-butanone as starting material, the MPV reduction reaction was carried out in different organic solvents according to the methodology described in Example 3, where the target solvent was substituted for toluene. Isopropanol (10%) was added to each solvent to ensure that the reaction was completed in a suitable time. Table 1 shows the results of these reactions. The (R,S)/(S,S) ratios increased when the reactions were carried out in nonproton polar solvents such as ethyl acetate and THF. Although not subject to any theoretical constraints, it is hypothesized that the hydrogen bonding between ketone 1 and Al(OiPr)3 may facilitate the reaction rate by maintaining the coordination state of 1 with the aluminum center, thus bringing the two reaction centers closer together. Table 1 lists the results of MPV reduction of 1 in different organic solvents.

References

[1] Patent: WO2011/60302, 2011, A1. Location in patent: Page/Page column 20
[2] Patent: CN104387299, 2016, B. Location in patent: Paragraph 0082; 0083
[3] Patent: US2002/151722, 2002, A1
[4] Tetrahedron Asymmetry, 1997, vol. 8, # 15, p. 2547 - 2552
[5] Patent: US5936104, 1999, A

(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

(3S)-3-(tert-Butoxycarbonyl)amino-1-chloro-4-phenyl-2-butanone Isopropyl alcohol Dichloromethane

Preparation Products

(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

Global( 115)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1796	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759	marketing1@neostarunited.com	China	8827	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3147	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +86-18949823763	sales@tnjchem.com	China	25333	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hangzhou Huarong Pharm Co., Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from (1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-11-19	(1S,2S)-(1-Benzyl-3-chloro-2-hydroxypropyl)carbamic acid tert-butyl ester 165727-45-7		1kg	99%	1000kg	Shanghai Joiny Pharmaceutical Co.,LTD
	2019-07-06	(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER 165727-45-7	$1.00	1KG	98%	100KG	Career Henan Chemical Co

(1S,2S)-(1-Benzyl-3-chloro-2-hydroxypropyl)carbamic acid tert-butyl ester
165727-45-7
$0.00
99%
Shanghai Joiny Pharmaceutical Co.,LTD

(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER
165727-45-7
$1.00
98%
Career Henan Chemical Co

(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER Spectrum

(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER(165727-45-7)¹HNMR

165727-45-7((1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER)Related Search:

[(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl-[(4-aminophenyl)sulfonyl]amino] propyl]-carbamic Acid tert-Butyl Ester 4-AMINO-N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-N-ISOBUTYLBENZENE-1-SULFONAMIDE tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride Benzyl chloride

TERT-BUTYL FORMATE tert-Butyl carbamate tert-butyl (2S,3S)-1-(4-(benzyloxy)phenyl)-4-chloro-3-hydroxybutan-2-ylcarbamate [1(S)-(4-NITRO-BENZYL)-3-CHLORO-2(S)-HYDROXY-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER N-BOC-3-CHLOROPROPYLAMINE

(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER

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(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER (1S,2S)-[3-CHLORO-2-HYDROXY-1-(PHENYLMETHYL)PROPYL]CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER (1S, 2S)-[3-CHLORO-2-HYDROXY-1-(PHENYLMETHYL)-PROPYL]CARBAMIC ACID, 1,1-DIMETHYLETHYL ETHER (2S,3S)-(-)-3-T-BUTOXYCARBONYLAMINO-1-CHLORO-4-PHENYL-BUTAN-2-OL (2S,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane (1S, 2S)-[3-Chloro-2-hydroxy-1-(phenylmethyl)- Tert-Butyl (2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-ylcarbamate Carbamic acid, N-[(1S,2S)-3-chloro-2-hydroxy-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester N-[(1S,2S)-3-chloro-2-hydroxy-1-(phenylmethyl)propyl]-Carbamic acid 1,1-dimethylethyl ester (2S,3S)-N-t-butyloxycarbonyl-3-amino-1-chloro-2-phenylbutanol (1S,2S)-[3-Chloro-2-hydroxy-1-(phenylmethyl)-propyl]carbamic acid, 1,1-dimethyle Carbamic acid, [(1S,2S)-3-chloro-2-hydroxy-1-(phenylmethyl)propyl]-,1,1-dimethylethyl ester (1S, 2S)-(1-benzyl-3-chloro-2-hydroxy-propyl)-carbamic acid ... (3s)-1-Chloro-3-(Boc-amino)-4-Phenyl-2-Butanol TIANFU CHEM--(1S, 2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER (2S，3S)-N-tert-Butoxycarbonyl-3-amino-1-chloro-2-hydroxy-4-phenylbutane 2S,3S-(1-Chloro-3-(t-butoxycarbonylamino)-4-phenyl-butan-2-ol) (3S)-3-(tert-Butoxycarbonyl)amino-1-chloro-4-phenyl-(2S)-butanol 165727-45-7 C15H22ClNO3