Rosiglitazone maleate
- CAS No.
- 155141-29-0
- Chemical Name:
- Rosiglitazone maleate
- Synonyms
- Avandi;BRL-49653c;RSIGLITAZONEMALEATE;RosiglitazoneTartrate;ROSIGLITAZONE MALEATE;Rosiglitazone-d3 Maleate;Rosiglitazone Maleate forM;β-D-Fructopyranose1-Sulfamate;Rosiglitazone Maleate (200 mg);Rosiglitazone maleate USP/EP/BP
- CBNumber:
- CB0133276
- Molecular Formula:
- C22H23N3O7S
- Molecular Weight:
- 473.5
- MDL Number:
- MFCD03427306
- MOL File:
- 155141-29-0.mol
| Melting point | 235-240°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 50 mg/ml). |
| pka | 6.1; 6.8(at 25℃) |
| form | White powder |
| color | White |
| BCS Class | 1 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months |
| InChIKey | HCDYSWMAMRPMST-NTCAYCPXSA-N |
| CAS DataBase Reference | 155141-29-0(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | rosiglitazone maleate |
| FDA UNII | KX2339DP44 |
| NCI Drug Dictionary | rosiglitazone maleate |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20/21/22-36/38 | |||||||||
| Safety Statements | 24/25-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Rosiglitazone maleate price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2513 | Rosiglitazone maleate Pharmaceutical Secondary Standard; Certified Reference Material | 155141-29-0 | 300MG | $170 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1605817 | Rosiglitazone maleate | 155141-29-0 | 200mg | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | 557366-M | Rosiglitazone - CAS 155141-29-0 - Calbiochem | 155141-29-0 | 10MG | $101 | 2022-05-15 | Buy |
| Cayman Chemical | 11884 | Rosiglitazone (maleate) ≥98% | 155141-29-0 | 100mg | $47 | 2024-03-01 | Buy |
| Cayman Chemical | 11884 | Rosiglitazone (maleate) ≥98% | 155141-29-0 | 1g | $188 | 2024-03-01 | Buy |
Rosiglitazone maleate Chemical Properties,Uses,Production
Description
Rosiglitazone maleate, belongs to a novel class of thiazolidine diones launched for the treatment of non-insulin-dependent diabetes mellitus (NIDDM), a disease characterized by a pancreatic β-cell defect and insulin resistance in the liver and peripheral tissues. The racemic base can be obtained by KnSvenagel condensation between 2, 4-thiazolidinedione and the corresponding 4-substituted benzaldehyde (itself prepared in 2 steps from 2-chloropyridine), followed by reduction of the benzylidene. Rosiglitazone was shown to be a potent agonist of peroxisome proliferator activated receptor-gamma (PPARgamma), a nuclear receptor involved in the differentiation of adipose tissue, without activating liver PPAR-alpha receptors. This activation of PPAR-gamma could mediate the down-regulation of leptin gene expression. In animal models, Rosiglitazone has been shown to normalize glucose metabolism and reduce the exogenous dose of insulin needed to achieve glycemic control. In patients with Type II diabetes, daily doses (4 or 8 mg) of Rosiglitazone significantly improved blood sugar control without affecting cardiac structure or function.
Chemical Properties
White To Off-White Solid
Originator
SmithKline Beecham (US)
Uses
Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo. Rosiglitazone is a prototypical TZD that has served as a reference compound for this class. It is a potent and selective PPARγ ligand that binds to the PPARγ ligand-binding domain with a Kd value of 43 nM. It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC50 values of approximately 30 nM and 100 nM, respectively. Rosiglitazone is active in vivo as an antidiabetic agent in the ob/ob mouse model, and has been used as an oral hypoglycemic agent in the treatment of type 2 diabetes in humans for many years.[Cayman Chemical]
Uses
Thiazole alkanes antidiabetic drug
Uses
Insulin sensitizer; binds to peroxisome proliferator activated receptor gamma (PPAR- γ).
Indications
Rosiglitazone maleate is an antihyperglycemic agent in the thiazolidinedione class. It is indicated for the treatment of patients with type 2 diabetes mellitus.
brand name
Avandia (GlaxoSmithKline).
General Description
A thiazolidinedione compound that acts as an anti-diabetic agent and serves as a potent and selective agonist of peroxisome proliferator-activated receptor-g (PPARg) (Kd ~40 nM) in fat cells. Shown to reduce fatty acid uptake and ameliorate lipid metabolism and insulin resistance in animal models of type II diabetes. Reported to activate both a1- and a2-containing AMPK complexes. Unlike troglitazone, it does not induce the activity of P4503A4. Significantly improves the differentiation of C3H10T1/2 stem cells into adipocytes. Shown to block estrogen synthesis by interfering with androgen binding to aromatase, but without affecting aromatase mRNA or protein expression.
storage
+4°C
References
1) Cantello et al. (1994), [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents; J. Med. Chem., 37 3977 2) Lehmann et al. (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPARgamma); J. Biol. Chem., 270 12953 3) Wilson et al. (1996), The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones; J. Med. Chem., 39 665 4) Haruya et al. (2012), PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein; Cell Metab., 15 395 5) Ruiz-Ojeda et al. (2016), Cell Models and their Application for Studying Adipogenic Differentiation in Relation to Obesity: A Review; Int. J. Mol. Sci., 17 E1040
Rosiglitazone maleate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3537 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
View Lastest Price from Rosiglitazone maleate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-03-27 | Rosiglitazone maleate
155141-29-0
|
US $80.00 / KG | 1KG | 99.9% | 500MT/month | XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD | |
 |
2023-02-14 | Rosiglitazone maleate
155141-29-0
|
US $0.00-0.00 / kg | 1kg | 98.0% | 1kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2021-08-11 | Rosiglitazone maleate
155141-29-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Rosiglitazone maleate
155141-29-0
- US $80.00 / KG
- 99.9%
- XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
-
- Rosiglitazone maleate
155141-29-0
- US $0.00-0.00 / kg
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Rosiglitazone maleate
155141-29-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd