ChemicalBook >> CAS DataBase List >>AGN 194310
AGN 194310
- CAS No.
- 229961-45-9
- Chemical Name:
- AGN 194310
- Synonyms
- AGN;CS-1211;VTP194310;VTP-194310;AGN 194310;VTP 194310;AGN-194310, 194310;AGN194310; AGN-194310; VTP194310; VTP 194310; VTP-194310;Benzoic acid, 4-[2-[4-(4-ethylphenyl)-2,2-dimethyl-2H-1-benzothiopyran-6-yl]ethynyl]-
- CBNumber:
- CB01346990
- Molecular Formula:
- C28H24O2S
- Molecular Weight:
- 424.55
- MDL Number:
- MOL File:
- 229961-45-9.mol
Last updated:2023-07-12 17:16:07
| Boiling point | 598.1±50.0 °C(Predicted) |
|---|---|
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | >16.8mg/mL in DMSO |
| form | Powder |
| pka | 4.02±0.10(Predicted) |
| FDA UNII | V2W3I5K9O0 |
AGN 194310 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2665 | AGN194310 ≥98% (HPLC) | 229961-45-9 | 5MG | $123 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2665 | AGN194310 ≥98% (HPLC) | 229961-45-9 | 25MG | $495 | 2024-03-01 | Buy |
| ApexBio Technology | B4702 | AGN194310 | 229961-45-9 | 5mg | $500 | 2021-12-16 | Buy |
| ApexBio Technology | B4702 | AGN194310 | 229961-45-9 | 10mM(in 1mL DMSO) | $514 | 2021-12-16 | Buy |
| ApexBio Technology | B4702 | AGN194310 | 229961-45-9 | 1mg | $158 | 2021-12-16 | Buy |
AGN 194310 Chemical Properties,Uses,Production
Biological Activity
AGN 194310 (VTP-194310) is a high-affinity, potent, and selective pan-antagonist of retinoic acid receptors (RARs) with Kd values of 3 nM and 2 nM for RARα, RARβ, and RARγ, respectively , 5 nM.
in vivo
AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment increases the number of granulocytes across haemopoietic compartments. A significant increase in the frequency of granulocyte -progenitor cells are observed in the bone marrow of mice after treatment with AGN194310.
| Animal Model: | Female C57Bl/6J mice (Five -week-old (34-37 days)) |
| Dosage: | 0.5 mg/kg/ day |
| Administration: | Oral gavage; every day; for 10 days |
| Result: | The number of granulocytes was significantly increased across haemopoietic compartments. Progenitor cells containing granulocytes also increased significantly. |
target
| RARα 3 nM (Kd) | RARβ 2 nM (Kd) | RARγ 5 nM (Kd) | < /table>
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
AGN 194310
AGN-194310, 194310
CS-1211
AGN194310; AGN-194310; VTP194310; VTP 194310; VTP-194310
VTP 194310
VTP194310
VTP-194310
AGN
Benzoic acid, 4-[2-[4-(4-ethylphenyl)-2,2-dimethyl-2H-1-benzothiopyran-6-yl]ethynyl]-
229961-45-9