EPROSARTAN | 133040-01-4

EPROSARTAN Properties

Melting point	250-253°C
storage temp.	Sealed in dry,2-8°C
solubility	Dichloromethane (Slightly), Methanol (Slightly)
form	Solid
color	Pale Yellow to Light Yellow
CAS DataBase Reference	133040-01-4
FDA UNII	2KH13Z0S0Y
ATC code	C09CA02

Pharmacokinetic data

Protein binding	98%
Excreted unchanged in urine	<2 (as metabolites)
Volume of distribution	13 Litres
Biological half-life	5-9 / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P305+P351+P338

EPROSARTAN price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	E590100	Eprosartan	133040-01-4	10mg	$70	2021-12-16	Buy
Matrix Scientific	094012	Eprosartan 95+%	133040-01-4	1g	$227	2021-12-16	Buy
American Custom Chemicals Corporation	API0000548	EPROSARTAN 95.00%	133040-01-4	1G	$284.55	2021-12-16	Buy
American Custom Chemicals Corporation	RDL0006807	EPROSARTAN-D4 95.00%	133040-01-4	5MG	$501.55	2021-12-16	Buy
Medical Isotopes, Inc.	D33956	Eprosartan-d6	133040-01-4	1mg	$600	2021-12-16	Buy

Product number	Packaging	Price	Buy
E590100	10mg	$70	Buy
094012	1g	$227	Buy
API0000548	1G	$284.55	Buy
RDL0006807	5MG	$501.55	Buy
D33956	1mg	$600	Buy

EPROSARTAN Chemical Properties,Uses,Production

Description

Teveten was launched in Germany for the treatment of hypertension. There are several ways in which it has been prepared, the shortest of which is four steps; beginning with displacement of 2-butyl-4-chloroimidazole-5-carboxaldehyde with methyl 4-(bromomethyl)benzoate. Teveten is an angiotensin Ⅱ antagonist selective for the AT, subtype receptor. It is a potent, highly selective, competitve antagonist with no agonist activity. Duration of action is similar to Enalapril (greater than 12 hr) but Teveten had a faster onset. While it is orally active, it rapidly dissociates from the receptor. This is contrary to its prolonged duration of action, which presumably results from slow removal from compartments within tissue, cells or matrix around the AT, receptor. It is not bound by BSA.

Chemical Properties

Light-Yellow Solid

Originator

SmithKline Beecham (UK)

Uses

Prototype of the imidazoleacrylic acid angiotensin II receptor antagonists. Antihypertensive

Uses

Eprosartan is a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists. Eprosartan is an antihypertensive.

Uses

Eprosartan (E590100) impurity.

Definition

ChEBI: A member of the class of imidazoles and thiophenes that is an angiotensin II receptor antagonist used for the treatment of high blood pressure.

brand name

Teveten

Clinical Use

Angiotensin-II antagonist
Hypertension

Drug interactions

Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia hypotension and renal impairment with ACE inhibitors and aliskiren.
Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity.
Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics.
Epoetin: increased risk of hyperkalaemia; antagonism of hypotensive effect.
Lithium: reduced excretion, possibility of enhanced lithium toxicity.
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Metabolism

Following oral and intravenous dosing with [14C] eprosartan in human subjects, eprosartan was the only drug-related compound found in the plasma and faeces. In the urine, approximately 20% of the radioactivity excreted was an acyl glucuronide of eprosartan with the remaining 80% being unchanged eprosartan
Eprosartan is eliminated by both biliary and renal excretion. Following intravenous [14C] eprosartan, about 61% of radioactivity is recovered in the faeces and about 37% in the urine. Following an oral dose of [14C] eprosartan, about 90% of radioactivity is recovered in the faeces and about 7% in the urine.

EPROSARTAN synthesis

Synthesis of EPROSARTAN from METHYL 4-[(2-BUTYL-5-FORMYL-1H-IMIDAZOL-1-YL)METHYL]BENZOATE and 2-Carbethoxy-3-(2-thienyl)propanoic acid

EPROSARTAN Preparation Products And Raw materials

Raw materials

Clotrimazole Methyl 4-(bromomethyl)benzoate 2-Carbethoxy-3-(2-thienyl)propanoic acid Methyl acrylate 1H-Imidazole-5-propanoic acid, 2-butyl-β-hydroxy-1-[[4-(methoxycarbonyl)phenyl]methyl]-α-(2-thienylmethyl)-, methyl ester

133040-02-5 METHYL 4-[(2-BUTYL-5-FORMYL-1H-IMIDAZOL-1-YL)METHYL]BENZOATE Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate Eprosartan Ethyl Methyl Diester Methyl-3-(2-thienyl)=propionate

2-Butyl-4-chloro-5-formylimidazole

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Preparation Products

EPROSARTAN Suppliers

Global( 121)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9604	58
Hebei Lingding Biotechnology Co., Ltd.	+86-18031140164 +86-19933155420	erin@hbldbiotech.com	China	879	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
ANHUI WITOP BIOTECH CO., LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Lingding Biotechnology Co., Ltd.	58
AFINE CHEMICALS LIMITED	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from EPROSARTAN manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-10-20	Eprosartan 133040-01-4	US $15.00 / KG	1KG	99%	9000kg/per week	Hebei Lingding Biotechnology Co., Ltd.
	2020-05-10	Eprosartan 133040-01-4	US $0.00-0.00 / Kg	1KG	99.0%	500 MT	Shaanxi Dideu Medichem Co. Ltd

Eprosartan
133040-01-4
US $15.00 / KG
99%
Hebei Lingding Biotechnology Co., Ltd.

Eprosartan
133040-01-4
US $0.00-0.00 / Kg
99.0%
Shaanxi Dideu Medichem Co. Ltd

133040-01-4(EPROSARTAN)Related Search:

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Tasosartan 4-Bromomethylbenzoic acid SB 201972 3-(2-THIENYL)PROPIONIC ACID Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate

Epalrestat iMpurity 4-(Hydroxymethyl)benzoic acid α-Methylcinnamaldehyde

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4-[2-Butyl-5-(2-carboxy-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-benzoic acid EPROSARTAN Eprosartan Mysylate (E)-3-[2-Butyl-1-[(4-carboxyphenyl)-methyl]imidazol-5-l]-2-(2-thienylmethyl)-2-propenoic Acid ((E)-3-[2-Butyl-1-[(4-carboxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoic Acid SKF-108566) SKF-108566J Teveten (E)- α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-y1]methylene]2-thiophenepropanoic acid (E)-3-[2-Butyl-1-(4-carboxybenzyl)-1H-imidazol-5-yl]-2-(2-thienylmethyl)acrylic acid 2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αE)- Des[2-(2-thienylMethyl)] Eprosartan-2-carboxylic Acid (E)-2-Butyl-1-(p-carboxybenzyl)-α-2-thenyliMidazole-5-acrylic Acid (αE)-α-[[2-Butyl-1-[(4-carboxyphenyl)Methyl]-1H-iMidazol-5-yl]Methylene]-2-thiophenepropanoic Acid Navixen SKB 108566 2-[[2-Butyl-1-[[4-(carboxyphenyl)]Methyl]-1H-iMidazol-5-yl]Methylene]propanedioic Acid 4-[[2-Butyl-5-(2,2-dicarboxyvinyl)-1H-iMidazol-1yl)Methylbenzoic Acid Eprosartan-d4 (E)-4-((2-Butyl-5-(2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl)-1H-iMidazol-1-yl)Methyl)benzoic acid -1H-imidazol-1-yl) -4-((2-Butyl-5-(2-carboxy-3-(thiophen-2-yl) prop-1-en-1-yl) CS-1951 EPROSARTAN USP/EP/BP Eprosartan D6 HClQ: What is Eprosartan D6 HCl Q: What is the CAS Number of Eprosartan D6 HCl Q: What is the storage condition of Eprosartan D6 HCl Q: What are the applications of Eprosartan D6 HCl EprosartanQ: What is Eprosartan Q: What is the CAS Number of Eprosartan Q: What is the storage condition of Eprosartan Q: What are the applications of Eprosartan TIANFU-CHEM EPROSARTAN Eprosartan (SKF-108566J) 13C6]-Eprosartan Eprosartan (E)-3-[2-Butyl-1-[(4-carboxyphenyl)methyl]-imidazol-5-yl]-2-(2- thienyl methyl)-2-propenoic acid 133040-01-4 C23H24N2O4S Aromatics Heterocycles Impurities Intermediates Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds