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arglabin

CAS No.
84692-91-1
Chemical Name:
arglabin
Synonyms
CS-1320;arglabin;Arglabine;Arglabin, BR;(+)-Arglabin;Arglabin 84692-91-1;Arglabin ((+)-Arglabin);(3aS)-2,3,3aβ,4,5β,6,6a,7,9aβ,9bα-Decahydro-6α,6aα-epoxy-6,9-dimethyl-3-methyleneazuleno[4,5-b]furan-2-one;(3aR,4aS)-1,4aα-Dimethyl-7-methylene-4a,5,6,6aα,9aβ,9bα-hexahydro-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(7H)-one;(3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-Hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one
CBNumber:
CB01355299
Molecular Formula:
C15H18O3
Molecular Weight:
246.3
MDL Number:
MFCD11519463
MOL File:
84692-91-1.mol
MSDS File:
SDS
Last updated:2024-01-05 22:10:32

arglabin Properties

Melting point 100-102 °C
Boiling point 404.6±45.0 °C(Predicted)
Density 1.22±0.1 g/cm3(Predicted)
storage temp. Amber Vial, -20°C Freezer, Under inert atmosphere
solubility Chloroform (Slightly)
form Solid
color Off-White
FDA UNII YS8UOP7QZ1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H319-H302-H315
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
NFPA 704
0
2 0

arglabin price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1570 Arglabin ≥98% (HPLC) 84692-91-1 1MG $108 2024-03-01 Buy
Sigma-Aldrich SML1570 Arglabin ≥98% (HPLC) 84692-91-1 5MG $435 2024-03-01 Buy
Cayman Chemical 19502 Arglabin 84692-91-1 500μg $49 2024-03-01 Buy
Cayman Chemical 19502 Arglabin 84692-91-1 1mg $92 2024-03-01 Buy
Cayman Chemical 19502 Arglabin 84692-91-1 5mg $380 2024-03-01 Buy
Product number Packaging Price Buy
SML1570 1MG $108 Buy
SML1570 5MG $435 Buy
19502 500μg $49 Buy
19502 1mg $92 Buy
19502 5mg $380 Buy

arglabin Chemical Properties,Uses,Production

Description

Arglabin is a new antineoplastic agent launched in Russia for the treatment of a variety of cancers. It is a sesquiterpene gamma-lactone extracted from Artemisia glabella, a plant from Kazakstan; it was first developed in Kazakstan followed by US and other countries as an ethical pharmaceutical. Arglabin can be obtained by resin extraction from A.glabella, purification by chromatography and finally recrystallization. Arglabin is a potent and selective inhibitor of farnesyl transferase, an enzyme critical to the function of the Ras oncogene in cancer cell reproduction. It showed a strong Inhibitory effect against tumor cells proliferation in in vitro models of transformed mouse hepatocytes and splenocytes. This cytotoxic effect against tumor cells was 50-100 times higher than that on intact cells. In many patients with various cancers, Arglabin was shown to stop or inhibit the tumour development, alone or in combination with other anticancer agents, and was reportedly well tolerated with few sideeffects. Promising response rates were also reported with Arglabin after treating other 《difficult-to-treat cancers》 such as breast, ovarian, lung or colon cancers.

Originator

NuOncology Labs (Kazakstan)

Uses

Arglabin is a sesquiterpene lactone used in the inhibition of glucose induced NF-kB activation and MCP-1/TGF-β1 expression treating diabetic nephropathy. Cytocoxic.

Definition

ChEBI: An organic heterotetracyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-dimethyl-1,3a,4,5,6,7-hexahydroazulen-5-yl group in which the double bond in the 7-membered ring has been epoxidised and in which the hydroxy group and the carboxy group have undergone formal condensation to give the corresponding gamma-lactone. It is found in Artemisia glabella. Arglabin-DMA HCl, the hydrochloride salt of the add ct resulting from the conjugate addition of dimethylamine to the ene-lactone moiety, has been successfully used in Khazakhstan for the treatment of breast, colon, ovarian and lung cancers.

storage

Room temperature

arglabin Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 95)Suppliers
Supplier Tel Email Country ProdList Advantage
Chongqing Zhihe Biopharmaceutical Co., Ltd.
+86-18580541567 +86-17782035140 sales@zhswyy.com China 382 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3620 58
Chengdu Greenpure Biopharma CO.,Ltd
18283602253 jancyzheng@gcgreenpure.com China 952 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897 sales@biopurify.com China 3424 58
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953 sales@pioneerbiotech.com China 3000 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
+8613815430202 sale02@cqherb.com CHINA 376 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Neostar United (Changzhou) Industrial Co., Ltd.
+86-519-519-85557386 marketing1@neostarunited.com China 8349 58

View Lastest Price from arglabin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
arglabin pictures 2024-03-27 arglabin
84692-91-1
US $0.00-0.00 / kg 0.10000000149011612kg ≥98% 20tons Chongqing Zhihe Biopharmaceutical Co., Ltd.
Arglabin 84692-91-1 pictures 2022-02-14 Arglabin 84692-91-1
84692-91-1
US $130.00 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
arglabin pictures 2019-07-06 arglabin
84692-91-1
US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • arglabin pictures
  • arglabin
    84692-91-1
  • US $0.00-0.00 / kg
  • ≥98%
  • Chongqing Zhihe Biopharmaceutical Co., Ltd.
  • Arglabin 84692-91-1 pictures
  • Arglabin 84692-91-1
    84692-91-1
  • US $130.00 / mg
  • ≥98%
  • NanJing Spring & Autumn Biological Engineering CO., LTD.
  • arglabin pictures
  • arglabin
    84692-91-1
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co
(3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-Hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one arglabin (3aR,4aS)-1,4aα-Dimethyl-7-methylene-4a,5,6,6aα,9aβ,9bα-hexahydro-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(7H)-one (3aS)-2,3,3aβ,4,5β,6,6a,7,9aβ,9bα-Decahydro-6α,6aα-epoxy-6,9-dimethyl-3-methyleneazuleno[4,5-b]furan-2-one 3H-Oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one, 5,6,6a,7,9a,9b-hexahydro-1,4a-diMethyl-7-Methylene-, [4aS-(3aS*,4aα,6aα,9aβ,9bα)]- Arglabine 3H-Oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one,5,6,6a,7,9a,9b-hexahydro-1,4a-dimethyl-7-methylene-, (3aR,4aS,6aS,9aS,9bR) Arglabin 84692-91-1 Arglabin, BR CS-1320 Arglabin ((+)-Arglabin) (+)-Arglabin 84692-91-1