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Nimesulide

Nimesulide
Nimesulide
CAS No.
51803-78-2
Chemical Name:
Nimesulide
Synonyms
Nide;nimed;AULIN;Nidol;R-805;Aufin;Nisuli;MESULID;Lizepat;Nisulid
CBNumber:
CB0138084
Molecular Formula:
C13H12N2O5S
Formula Weight:
308.31
MOL File:
51803-78-2.mol

Nimesulide Properties

Melting point:
140-146°C
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
form 
neat
pka
pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
Water Solubility 
Soluble in water (<50 &#181;g/ml), 1:10 DMSO:PBS (pH 7.2) (<200 &#181;g/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
λmax
391nm(H2O)(lit.)
Merck 
14,6548
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
HYWYRSMBCFDLJT-UHFFFAOYSA-N
CAS DataBase Reference
51803-78-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  36-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  PB0970000
HazardClass  6.1
PackingGroup  III
Toxicity LD50 orally in rats: 324 mg/kg (Swingle, Moore)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P321 Specific treatment (see … on this label).
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Nimesulide price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N1016 Nimesulide 51803-78-2 1g $23.7 2018-11-13 Buy
Sigma-Aldrich N1016 Nimesulide 51803-78-2 5g $84.9 2018-11-13 Buy
TCI Chemical N0984 Nimesulide >98.0%(HPLC)(T) 51803-78-2 1g $21 2018-11-22 Buy
TCI Chemical N0984 Nimesulide >98.0%(HPLC)(T) 51803-78-2 5g $59 2018-11-22 Buy
Alfa Aesar J63699 Nimesulide 51803-78-2 5g $48.7 2018-11-13 Buy

Nimesulide Chemical Properties,Uses,Production

Description

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is indicated for the treatment of acute pain, symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults. However, due to the risk of causing hepatotoxicity, it should not be taken long-term. It has also been withdrawn from the markets in many countries. It mechanism of action is through targeting on various key mediators in the inflammatory process such as COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.

Chemical Properties

Yellow Needle-Like Crystals

Uses

Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production

Uses

Labelled Nimesulide (N477500). Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.

Uses

Antiinflammatory;'Cyclooxygenase 2 inhibitor

Uses

For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.

Uses

Labelled Nimesulide . Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.;Labeled Nimesulide, intended for use as an internal standard for th

Uses

Nimesulide is a selective inhibitor of COX-2. The IC50 values are 70 and 1.27 μM for human recombinant COX-1 and -2 (at 20 μM arachidonic acid), respectively, and 22 and 0.03 μM for ovine COX-1 and -2 (at 100 μM arachidonic acid), respectively.[Cayman Chemical]

Biological Activity

Selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo . Reported to produce fewer gastrointestinal side effects than standard NSAIDs.牋.

References

https://en.wikipedia.org/wiki/Nimesulide
https://www.drugbank.ca/drugs/DB04743

Nimesulide Preparation Products And Raw materials

Raw materials

Preparation Products


Nimesulide Suppliers

Global( 196)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 500 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Hubei Jusheng Technology Co.,Ltd.
86-155-27864001
peter@hubeijusheng.com CHINA 18004 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885
021-65675885 info@efebio.com China 9941 58
Hubei Hengluyuan Technology Co., Ltd. +86-027-88188016; +86-027-88188096
+86-027-51835635 hbhlykj@hotmail.com CHINA 928 58
Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
+86-21-57758967 sales@boylechem.com China 2220 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

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