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ETAZOLATE

ETAZOLATE structure

CAS No.: 51022-77-6

Chemical Name:: ETAZOLATE

Synonyms: SQ 64442;SQ 20009;ETAZOLATE;Zinc00001379;Etazolate hydrochlor;ETAZOLATE HYDROCHLORIDE;1-Ethyl-4-[2-(1-Methylethylidene)hydrazinyl]-;1-Ethyl-4-isopropylidenehydrazino-1H-pyrazolo[3,4-b]-1-pyridine-5-carboxylic Acid Ethyl Ester;1-Ethyl-4-(2-isopropylidenehydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester;1-Ethyl-4-isopropylidenehydrazino- 1H-pyrazolo[3,4-β]-1-pyridine-5-carboxylic Acid Ethyl Ester

CBNumber:: CB0140566

Molecular Formula:: C14H19N5O2

Molecular Weight:: 289.33

MDL Number:: MFCD00600136

MOL File:: 51022-77-6.mol

MSDS File:: SDS

Last updated:2023-05-04 17:34:39

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ETAZOLATE Properties

Melting point	193-194°C
Boiling point	427.6±55.0 °C(Predicted)
Density	1.25±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	H₂O: >20 mg/mL Solutions should be freshly prepared.
pka	9.94±0.70(Predicted)
form	solid
color	white
CAS DataBase Reference	51022-77-6
FDA UNII	I89Y79062L

SAFETY

Risk and Safety Statements

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3

ETAZOLATE price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	E889250	Etazolate	51022-77-6	25mg	$305	2021-12-16	Buy
Usbiological	448517	Etazolate Hydrochloride	51022-77-6	1mg	$326	2021-12-16	Buy
Usbiological	255268	Etazolate hydrochloride	51022-77-6	10mg	$353	2021-12-16	Buy
Usbiological	E8440	Etazolate	51022-77-6	10mg	$403	2021-12-16	Buy
TRC	E889250	Etazolate	51022-77-6	50mg	$545	2021-12-16	Buy

Product number	Packaging	Price	Buy
E889250	25mg	$305	Buy
448517	1mg	$326	Buy
255268	10mg	$353	Buy
E8440	10mg	$403	Buy
E889250	50mg	$545	Buy

ETAZOLATE Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Etazolate Hydrochloride is an acyclic nucleotide phosphodiesterase 4 inhibitor, which also exhibits antidepressant-like activity in acute and chronic mouse and rat model of depression.

Uses

An inhibitor of phosphodiesterase IV, about 8 times more active for cAMP than cGMP.

Uses

PDE inhibitor

Definition

ChEBI: Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as a neuroprotective agent, an antipsychotic agent, a phosphodiesterase IV inhibitor, an anxiolytic drug, an antidepressant, an alpha-secretase activator and a GABA agent. It is a hydrazone, an ethyl ester and a pyrazolopyridine.

Biological Activity

Phosphodiesterase inhibitor, selective for PDE4 (IC 50 = 2.0 μ M).

ETAZOLATE Preparation Products And Raw materials

Raw materials

Preparation Products

ETAZOLATE Suppliers

Global( 52)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11605	64
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35906	56
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8073	58
Shanghai Synchem Pharma Co., ltd	021-61984905-1 18016477331	synchempharma@aliyun.com	China	6454	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60

Supplier	Advantage
Career Henan Chemica Co	58
Amadis Chemical Company Limited	58
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Wuhan Chemwish Technology Co., Ltd	56
Chemsky（shanghai）International Co.,Ltd.	50
Shanghai TaoSu Biochemical Technology Co., Ltd.	58
Shanghai Synchem Pharma Co., ltd	55
EMMX Biotechnology LLC	60

51022-77-6(ETAZOLATE)Related Search:

4-AMINO-3-FORMYLPYRIDINE 4-AMINO-3-FORMYLPYRIDINE HCL 4-HYDRAZINOPYRIDINE HYDROCHLORIDE 4-Amino-3-pyridinecarboxylic acid 1H-PYRAZOLO[3,4-B]PYRIDIN-4-AMINE

(4-AMINO-PYRIDIN-3-YL)-METHANOL Methyl 4-aminopyridine-3-carboxylate 3-Methyl-4-aminopyridine Pyridine, 4-hydrazino-3-methyl- (9CI) 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID

4-AMINOPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER ETAZOLATE 4-hydrazinylpyridine hydrochloride

1of3

ETAZOLATE ETAZOLATE HYDROCHLORIDE 1-ETHYL-4-[(1-METHYLETHYLIDENE)HYDRAZINO]-1H-PYRAZOLO-[3,4-B]-PYRIDINE-5-CARBOXYLIC ACID, ETHYL ESTER HYDROCHLORIDE 1-ETHYL-4-[(1-METHYLETHYLIDENE)HYDRAZINO]-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL ESTER, HCL SQ 20009 1-Ethyl-4-[2-(1-methylethylidene)hydrazinyl]-1H-pyrazolo[3,4-β]pyridine-5-carboxylic Acid Ethyl Ester 1-Ethyl-4-isopropylidenehydrazino- 1H-pyrazolo[3,4-β]-1-pyridine-5-carboxylic Acid Ethyl Ester SQ 64442 1-Ethyl-4-[2-(1-methylethylidene)hydrazinyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic Acid Ethyl Ester 1-Ethyl-4-isopropylidenehydrazino-1H-pyrazolo[3,4-b]-1-pyridine-5-carboxylic Acid Ethyl Ester 1-Ethyl-4-(2-isopropylidenehydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester Zinc00001379 1-Ethyl-4-[2-(1-Methylethylidene)hydrazinyl]- 1-Ethyl-4-(N-isopropylidene-hydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester hydrochloride 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 1-ethyl-4-[2-(1-methylethylidene)hydrazinyl]-, ethyl ester Etazolate hydrochlor 51022-77-6 C14H20ClN5O2 C14H20N5O2Cl G Proteins and Cyclic Nucleotides Cyclic Nucleotide Metabolism Phosphodiesterase Inhibitors BioChemical Cell Signaling and Neuroscience Cell Biology All Inhibitors Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Cyclic Nucleotide related