BAVACHIN
- CAS No.
- 19879-32-4
- Chemical Name:
- BAVACHIN
- Synonyms
- BAVACHIN;Bavachin from Psoralea coryfolia, >=97% (HPLC);(S)-7-Hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one;7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one;(2S)-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one;(S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;(2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-, (2S)-
- CBNumber:
- CB01433061
- Molecular Formula:
- C20H20O4
- Molecular Weight:
- 324.37
- MDL Number:
- MFCD11617359
- MOL File:
- 19879-32-4.mol
| Boiling point | 558.3±50.0 °C(Predicted) |
|---|---|
| Density | 1.244 |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | ≤20mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 8.27±0.40(Predicted) |
| color | White |
| CAS DataBase Reference | 19879-32-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| NFPA 704 |
|
BAVACHIN price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11685 | Bavachin ≥98% | 19879-32-4 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 11685 | Bavachin ≥98% | 19879-32-4 | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 11685 | Bavachin ≥98% | 19879-32-4 | 10mg | $214 | 2024-03-01 | Buy |
| TRC | B129200 | Bavachin | 19879-32-4 | 50mg | $130 | 2021-12-16 | Buy |
| Usbiological | 299987 | Bavachin | 19879-32-4 | 20mg | $470 | 2021-12-16 | Buy |
BAVACHIN Chemical Properties,Uses,Production
Description
Bavachin is a flavonoid first isolated from seeds of P. corylifolia. It is a phytoestrogen that activates the estrogen receptors ERα and ERβ (EC50s = 320 and 680 nM, respectively). Through this action, bavachin stimulates osteoblast proliferation and differentiation and prevents bone loss following ovariectomy in rats. Bavachin less potently inhibits acyl-coenzyme A:cholesterol acyltransferase (IC50 = 86 μM).
Uses
Bavachin has therapeutic potential for type 2 diabetes by activating insulin signaling pathways. Also, it has anabolic and potent anticatabolic biological effects on chondrocytes. Strong inhibitor of human UDP-glucuronosyltransferase (UGT1A1)
target
NF-kB | p65 | IkB | VEGFR | IL Receptor | AP-1 | AMPK | PPAR | GLUT | Akt | IKK | Estrogen receptor α | Estrogen receptor β
References
[1] choi j h, rho m c, lee s w, et al. bavachin and isobavachalcone, acyl-coenzyme a: cholesterol acyltransferase inhibitors from psoralea corylifolia[j]. archives of pharmacal research, 2008, 31(11): 1419-1423.
[2] park j, kim d h, ahn h n, et al. activation of estrogen receptor by bavachin from psoralea corylifolia[j]. biomolecules & therapeutics, 2012, 20(2): 183-188.
[3] lee h, li h, noh m, et al. bavachin from psoralea corylifolia improves insulin-dependent glucose uptake through insulin signaling and ampk activation in 3t3-l1 adipocytes[j]. international journal of molecular sciences, 2016, 17(4): 527.
BAVACHIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from BAVACHIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-18 | BAVACHIN
19879-32-4
|
US $50.00 / KG | 1KG | 99% | 20tons | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-02-24 | Bavachin
19879-32-4
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2022-10-29 | BAVACHIN
19879-32-4
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Guanlang Biotechnology Co., Ltd. |
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