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Sitagliptin

Sitagliptin
Sitagliptin structure
CAS No.
486460-32-6
Chemical Name:
Sitagliptin
Synonyms
Janumet;Hsdb 7516;C53323300;Sitagliptin;Sitaglipitin;Sitagliptin-D4;Unii-qfp0p1dv7z;Sitagliptin API;Sitagliptin base;Sitagliptin-D4 HCL
CBNumber:
CB01449778
Molecular Formula:
C16H15F6N5O
Formula Weight:
407.32
MOL File:
486460-32-6.mol

Sitagliptin Properties

CAS DataBase Reference
486460-32-6(CAS DataBase Reference)

Sitagliptin Chemical Properties,Uses,Production

Description

Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral drug launched for the treatment of type 2 diabetes. It acts by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. Incretin hormones, including glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic αcells, which leads to reduced hepatic glucose production.

Originator

Merck (US)

Uses

Labeled Sitagliptin , intended for use as an internal standard for the quantification of Sitagliptin by GC- or LC-mass spectrometry.

Definition

ChEBI: A triazolopyrazine that exhibits hypoglycemic activity.

brand name

Januvia

Sitagliptin Preparation Products And Raw materials

Raw materials

Preparation Products


Sitagliptin Suppliers

Global( 227)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3193 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21701 58
Hi-Tech Chemistry Corp
0519-86626038
yuhh@hitechem.com CHINA 811 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 fandachem@gmail.com CHINA 2861 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
AB PharmaTech,LLC
323-480-4688
323-480-4688 sales01@abpharmatechusa.com United States 989 55

View Lastest Price from Sitagliptin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-09-09 Sitagliptin
486460-32-6
US $0.00 / Kg/Drum 10g 99% 10MT hdzhl biotechnology co., ltd
2019-09-09 Sitagliptin
486460-32-6
US $0.00 / KG 10g 99% 10MT hdzhl biotechnology co., ltd
2018-07-25 Sitagliptin
486460-32-6
US $100.00 / KG 1KG 98% 100KG career henan chemical co

486460-32-6(Sitagliptin)Related Search:


  • Sitagliptin free base
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  • (R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
  • Sitagliptin (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
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  • Sitagliptin-D4 HCL
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  • (S)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
  • Sitaglipitin
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  • 486460-32-6
  • 1011232-08-8
  • C16H15F6N5O
  • API
  • -
  • Pharmaceutical intermediate
  • Heterocycles
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