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(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride structure

CAS No.: 866783-13-3

Chemical Name:: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Synonyms: Ivabradine Impurity 17 HCl;(1R)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride;(7S)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride;(1S)-4;Ivabradine RC 6 (HCl);Ivebradine impurity 3;Ivabradine Impurity 85;Ivabradine Intermediate;Ivabradine intermediate1;Ivabradine Impurity 7 HCL

CBNumber:: CB01455900

Molecular Formula:: C12H18ClNO2

Molecular Weight:: 243.73

MDL Number:: MFCD13194843

MOL File:: 866783-13-3.mol

MSDS File:: SDS

Last updated:2023-09-06 17:45:48

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(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Properties

Melting point	>216°C (dec.)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
form	Solid
color	White to Off-White
InChI	InChI=1/C12H17NO2.ClH/c1-13-7-9-4-8-5-11(14-2)12(15-3)6-10(8)9;/h5-6,9,13H,4,7H2,1-3H3;1H/t9-;/s3
InChIKey	SWSAIQSQSDOONK-OVMXBOEKNA-N
SMILES	COC1=CC2[C@@H](CNC)CC=2C=C1OC.Cl \|&1:5,r\|
CAS DataBase Reference	866783-13-3(CAS DataBase Reference)
FDA UNII	JF52QM9RUB

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	29214990

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D461760	(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutaneHydrochloride	866783-13-3	250mg	$110	2021-12-16	Buy
Biosynth Carbosynth	FD150184	(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutaneHydrochloride	866783-13-3	500mg	$125	2021-12-16	Buy
AK Scientific	X0048	(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutanehydrochloride	866783-13-3	250mg	$130	2021-12-16	Buy
Biosynth Carbosynth	FD150184	(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutaneHydrochloride	866783-13-3	1g	$200	2021-12-16	Buy
AK Scientific	X0048	(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutanehydrochloride	866783-13-3	1g	$250	2021-12-16	Buy

Product number	Packaging	Price	Buy
D461760	250mg	$110	Buy
FD150184	500mg	$125	Buy
X0048	250mg	$130	Buy
FD150184	1g	$200	Buy
X0048	1g	$250	Buy

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Chemical Properties,Uses,Production

Uses

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride is an intermediate used in preparation of Ivabradine (I940500) which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node.

Uses

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane is an intermediate used in preparation of Ivabradine (I940500) which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node.

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride synthesis

Synthesis of (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride from (S)-(4,5-diMethoxy-1,2-dihydrocyclobutabenzen-1-yl)-N-MethylMethanaMine

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Preparation Products And Raw materials

Raw materials

Bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid, 3,4-dimethoxy-, (7R)- (S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid N-methyl-amide 4,5-Dimethoxy-1-cyanobenzocyclobutane 3-(2-BROMO-4,5-DIMETHOXYPHENYL)PROPANENITRILE (S)-(4,5-diMethoxy-1,2-dihydrocyclobutabenzen-1-yl)-N-MethylMethanaMine

(3,4-DiMethyoxy-bicyclo(4,2,0)octa-1(6),2,4-trien-7-ylMethyl)-carbaMic acid ethyl ester Ivabradine Impurity 68 4,5-Dimethoxybenzocyclobutene-1-carboxylic acid

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Preparation Products

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Suppliers

Global( 260)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.	+8615065888978	admin@hsnordpharma.com	China	92	58
Senova Technology Co. Ltd.	+86-0755-86703119 +8618503098836	info@senovatech.com	China	349	58
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd	+86-010-83386758 +86-18810831598	jennifer@lianben.com	China	85	58
Jiangsu Yutian pharmaceutical Co.,Ltd.	+undefined-0518-86098006 +undefined19851887368	lvan.hui@jsytsw.com	China	80	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9350	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Ningbo Nuobai Pharmaceutical Co., Ltd.	18758416982	Fisheryu@nbpharm.com	China	13	58

Supplier	Advantage
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.	58
Senova Technology Co. Ltd.	58
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd	58
Jiangsu Yutian pharmaceutical Co.,Ltd.	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Ningbo Nuobai Pharmaceutical Co., Ltd.	58

View Lastest Price from (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-11-01	(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 866783-13-3	US $0.00-0.00 / kg	0.1kg	99.0%min	200kg	Hangzhou ICH Biofarm Co., Ltd
2023-09-06	(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 866783-13-3	US $0.00 / kg	1kg	0.99	500kg/M	Hebei Yanxi Chemical Co., Ltd.
2023-07-19	(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 866783-13-3	US $30.00 / KG	1KG	99%	20 Tons	Wuhan wingroup Pharmaceutical Co., Ltd

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
866783-13-3
US $0.00-0.00 / kg
99.0%min
Hangzhou ICH Biofarm Co., Ltd

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
866783-13-3
US $0.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
866783-13-3
US $30.00 / KG
99%
Wuhan wingroup Pharmaceutical Co., Ltd

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(1S)-4,5-Dimethoxy-1-(Methylaminomethyl)-Benzocyclobutane Hcl (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride (1S)-4,5-Dimethoxy-1-(methylaminoethyl)benzocyclobutane HCl (S)-N-[(4,5-diMethoxybenzocyclobut-1-yl)Methyl ]-N-MethylaMine h (S)-(4,5-diMethoxy-1,2-dihydrocyclobutabenzen-1-yl)MethanaMine 3,4-diMethoxy-N-Methyl-bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine hydrochloride Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl-, hydrochloride (1S)-4,5-DiMethoxy-1-[(MethylaMino)Methyl]benzocyclobutane (1S)-4,5-DiMethoxy-1-[(MethylaMino)Methyl]benzoc 3,4-dimethoxy-N-methyl-bicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride (For Ivabradine) Ivabradine hydrochloride main chain Ivabradine intermediate1 (S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine hydrochloride {[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amine hydrochloride (1S)-4 5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Ivabradine Impurity 85 Ivabradine related compound Ivabradine related compound 12 (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocycl [N-[[3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL] CARBONYL]-N-METHYLAMINE] S-4,5-Dimethoxy-1-[(methylamino)methyl]benzo cyclobutane hydrochloride (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochlorideY655 (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride CAS 866783-13-3 (1S)-4,5-Dimethoxy-1-[(methylamine)methyl]benzocyclobutane HCl (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane h... Ivabradine RC 6 (HCl) Ivabradine Impurity 7 HCL (7S)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride (1R)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Ivabradine Impurity 17 HCl Ivebradine impurity 3 Ivabradine Intermediate 866783-13-3