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Canertinib

CAS No.
267243-28-7
Chemical Name:
Canertinib
Synonyms
CS-152;PD-183805;Canetinib;Canertinib base;quinazolin-6-yl);CI-1033; PD-183805;CI-1033(Canertinib);Canertinib (CI-1033);Canertinib USP/EP/BP;-7-(3-morpholinopropoxy)
CBNumber:
CB01458390
Molecular Formula:
C24H25ClFN5O3
Molecular Weight:
485.94
MDL Number:
MFCD09837878
MOL File:
267243-28-7.mol
MSDS File:
SDS
Last updated:2023-10-08 15:17:26

Canertinib Properties

Melting point 188-190°
Boiling point 691.0±55.0 °C(Predicted)
Density 1.355±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility insoluble in H2O; ≥10.1 mg/mL in EtOH; ≥12.15 mg/mL in DMSO with gentle warming
form Yellow powder.
pka 12.09±0.43(Predicted)
CAS DataBase Reference 267243-28-7
FDA UNII C78W1K5ASF

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Canertinib price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C175600 Canertinib 267243-28-7 10mg $65 2021-12-16 Buy
ChemScene CS-0121 Canertinib 98.02% 267243-28-7 100mg $137 2021-12-16 Buy
AK Scientific Y0252 Canertinib 267243-28-7 25mg $170 2021-12-16 Buy
ApexBio Technology A1845 Canertinib(CI-1033) 267243-28-7 10mg $50 2021-12-16 Buy
ApexBio Technology A1845 Canertinib(CI-1033) 267243-28-7 10mM(in 1mL DMSO) $50 2021-12-16 Buy
Product number Packaging Price Buy
C175600 10mg $65 Buy
CS-0121 100mg $137 Buy
Y0252 25mg $170 Buy
A1845 10mg $50 Buy
A1845 10mM(in 1mL DMSO) $50 Buy

Canertinib Chemical Properties,Uses,Production

Uses

Antineoplastic; irreversible pan-erbB tyrosine kinase inhibitor used to treat cancer.

Uses

CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.

Uses

Canertinib is a kind of irreversible pan-erbB tyrosine kinase inhibitor used to treat cancer.

Definition

ChEBI: A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a propenamido group at the 6-position, and a 3-morpholinopropoxy group at the 7-position.

Biological Activity

canertinib (also known as ci-1033), a 3-chloro, 4-fluoro, 4-anilinoquinazoline, is an orally available, potent and irreversible pan-erbb tyrosine kinase inhibitor that inhibits egfr, her2 and her4 in vitro with the half maximal inhibition concentration ic50 of 0.8 nm, 19 nm and 7 nm respectively [1].canertinib irreversibly binds into the atp pocket within the tk domain of all erbb family members, where the acrylamide side-chain at position c6 of canertinib is brought into close proximity with cysteines of erbb members, followed by the rapid formation of a covalent bond, which permanently inactivates the catalytically active erb1, erb2 and erb4 family members and effectively inhibits erbb3-dependent signaling [2].

References

[1] michelle arkin, mark m. moasser. her2 directed small molecule antagonists. curr opin investig drugs. author manuscript; available in pmc 2011 february 1. published in final edited form as: curr opin investig drugs. 2008 december; 9(12): 1264–1276.
[2] calvo e, tolcher aw, hammond la, patnaik a, de bono js, eiseman ia, olson sc, lenehan pf, mccreery h, lorusso p, rowinsky ek. administration of ci-1033, an irreversible pan-erbb tyrosine kinase inhibitor, is feasible on a 7-day on, 7-day off schedule: a phase i pharmacokinetic and food effect study. clin cancer res. 2004 nov 1;10(21):7112-20.

Canertinib Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 164)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5990 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838 chloewu@chicopharm.cn CHINA 341 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289 contact@trustwe.com China 5739 58

View Lastest Price from Canertinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Canertinib pictures 2023-10-09 Canertinib
267243-28-7
US $0.00 / kg 1kg 0.99 20tons Hebei Yanxi Chemical Co., Ltd.
CANERTINIB USP/EP/BP pictures 2021-07-07 CANERTINIB USP/EP/BP
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
canertinib pictures 2021-07-02 canertinib
267243-28-7
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Canertinib pictures
  • Canertinib
    267243-28-7
  • US $0.00 / kg
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • canertinib pictures
  • canertinib
    267243-28-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Canertinib Spectrum

CI-1033(Canertinib) PD-183805 CI-1033; PD-183805 Canertinib base Canetinib Canertinib (CI-1033) N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide N-[4-(3-chloro-4-fluoro-anilino)-7-(3-morpholinopropoxy)quinazolin-6-yl]acrylamide N-[4-(3-chloro-4-fluoroanilino)-7-(3-Morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-en 2-PropenaMide,N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-(4-Morpholinyl)propoxy]-6-quinazolinyl]- N-(4-(3-chloro-4-fluorophenylamino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide Canertinib N-[4-(3-Chloro-4-fluoroanilino)-7-(3-morpholinopropoxy)quinazolin-6-yl]acrylamide N-[4-(3-Chloro-4-fluoroanilino)-7-(3-morpholinopropoxy)quinazolin-6-yl]acrylamide Canertinib (CI-1033) Canertinib--CI-1033, PD-183805 -7-(3-morpholinopropoxy) N-(4-((3-Chloro-4-fluorophenyl) quinazolin-6-yl) CS-152 CI-1033; PD-183805; CI1033; CI 1033; PD183805; PD 183805 CI-1033 (Canertinib, PD-183805) Canertinib USP/EP/BP ErbB-1,inhibit,Inhibitor,PD 183805,PD183805,Epidermal growth factor receptor,CI 1033,HER1,Orthopoxvirus,Canertinib,EGFR,CI1033 267243-28-7 C23H23ClFN5O3 Inhibitors