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Ibudilast

Ibudilast
Ibudilast
CAS No.
50847-11-5
Chemical Name:
Ibudilast
Synonyms
Ketas;KC-404;AV 411;Pinatos;budilast;Eyevinal;lbudilast;IBUDILAST;IBUDILAST-D7;Ibudilast, >=98%
CBNumber:
CB0145945
Molecular Formula:
C14H18N2O
Formula Weight:
230.31
MOL File:
50847-11-5.mol

Ibudilast Properties

Melting point:
53-54°C
Boiling point:
175°C/7.5mmHg(lit.)
Density 
1.09
refractive index 
1.5500 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: 28 mg/mL, soluble
form 
solid
color 
white
Merck 
14,4879
InChIKey
ZJVFLBOZORBYFE-UHFFFAOYSA-N
CAS DataBase Reference
50847-11-5(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  UR0711200
Toxicity LD50 i.v. in mice: 260 mg/kg (Irikura, 1973)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501 Dispose of contents/container to..…

Ibudilast price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I0157 Ibudilast ≥99% (HPLC), solid 50847-11-5 10mg $243 2018-11-13 Buy
Sigma-Aldrich I0157 Ibudilast ≥99% (HPLC), solid 50847-11-5 50mg $931 2018-11-13 Buy
TCI Chemical I0740 Ibudilast >98.0%(HPLC)(T) 50847-11-5 20mg $154 2018-11-22 Buy
TCI Chemical I0740 Ibudilast >98.0%(HPLC)(T) 50847-11-5 100mg $516 2018-11-22 Buy
Cayman Chemical 14832 Ibudilast ≥98% 50847-11-5 1mg $25 2018-11-13 Buy

Ibudilast Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

a phosphodiesterase inhibitor with anti-inflammatory activity

Uses

A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)

Uses

Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]

Biological Activity

Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Ibudilast Preparation Products And Raw materials

Raw materials

Preparation Products


Ibudilast Suppliers

Global( 163)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22058 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 301 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 956 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20001 58
hebei chisure biotechnology co.,ltd
0311 66567340
0311 66567340 admin@SpeedGainpharma.com CHINA 518 58
Shandong Chenxi Pharmaceutical Co., Ltd. 0531-88803416 13153166250
0531-88803416 sales@chemedpharma.com China 55 58
Jinan Create Pharmaceutical Technology Co., Ltd. 13287783460
+86 (531) 8806-5293 3166282224@qq.com China 27 58

View Lastest Price from Ibudilast manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-15 Ibudilast
50847-11-5
US $1.00 / kg 1kg 99% Customized career henan chemical co
2018-07-19 Ibudilast
50847-11-5
US $10.00 / KG 1KG 99% 5000kg/month hebei chisure biotechnology co.,ltd

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