ChemicalBook >> CAS DataBase List >>Ibudilast

Ibudilast

CAS No.
50847-11-5
Chemical Name:
Ibudilast
Synonyms
Ketas;KC-404;AV 411;MN-166;CS-351;Pinatos;Eyevinal;budilast;IBUDILAST;lbudilast
CBNumber:
CB0145945
Molecular Formula:
C14H18N2O
Molecular Weight:
230.31
MDL Number:
MFCD00864808
MOL File:
50847-11-5.mol
Last updated:2024-03-26 17:16:27

Ibudilast Properties

Melting point 53-54°C
Boiling point 175°C/7.5mmHg(lit.)
Density 1.09
refractive index 1.5500 (estimate)
storage temp. Sealed in dry,2-8°C
solubility DMSO: 28 mg/mL, soluble
form solid
pka 1.22±0.30(Predicted)
color white
Merck 14,4879
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
InChIKey ZJVFLBOZORBYFE-UHFFFAOYSA-N
SMILES C(C1=C2N(N=C1C(C)C)C=CC=C2)(=O)C(C)C
CAS DataBase Reference 50847-11-5(CAS DataBase Reference)
FDA UNII M0TTH61XC5
NCI Drug Dictionary ibudilast
ATC code R03DC04

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  UR0711200
HS Code  2933.99.8290
Toxicity LD50 i.v. in mice: 260 mg/kg (Irikura, 1973)
NFPA 704
0
2 0

Ibudilast price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I0157 Ibudilast ≥99% (HPLC), solid 50847-11-5 10mg $313 2024-03-01 Buy
Sigma-Aldrich I0157 Ibudilast ≥99% (HPLC), solid 50847-11-5 50mg $1190 2024-03-01 Buy
TCI Chemical I0740 Ibudilast >98.0%(HPLC)(T) 50847-11-5 20mg $40 2024-03-01 Buy
TCI Chemical I0740 Ibudilast >98.0%(HPLC)(T) 50847-11-5 100mg $117 2024-03-01 Buy
Cayman Chemical 14832 Ibudilast ≥98% 50847-11-5 5mg $44 2024-03-01 Buy
Product number Packaging Price Buy
I0157 10mg $313 Buy
I0157 50mg $1190 Buy
I0740 20mg $40 Buy
I0740 100mg $117 Buy
14832 5mg $44 Buy

Ibudilast Chemical Properties,Uses,Production

Description

Ibudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.

Chemical Properties

White Solid

Originator

Kyorin (Japan)

Uses

a phosphodiesterase inhibitor with anti-inflammatory activity

Uses

A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)

Uses

Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]

Definition

ChEBI: Ibudilast is a pyrazolopyridine.

brand name

Ketas

Biological Activity

Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Biochem/physiol Actions

Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.

in vitro

ibudilast could potently inhibit purified human pde4a, 4b, 4c and 4d with ic50 values at 54, 65, 239 and 166 nm, respectively. ibudilast was also able to effectively block lps-induced tumor necrosis factor and n-formyl-metleu-phe-induced leukotriene b4 biosynthesis in human whole blood [1].

in vivo

rats received a daily oral administration of 10, 30 or 60 mg/kg ibudilast. results showed that in the vehicle-treated animals, white matter lesions and microglial activation occurred in the optic tract, internal capsule and corpus callosum. a low dose of ibudilast failed to suppress the white matter lesions and microglial activation, whereas a dose of either 30 or 60 mg/kg ibudilast ameliorated these lesions [2].

IC 50

54-239 nm

storage

Store at RT

References

1) Kishi et al. (2001), Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall; Cardiovasc. Drug Rev., 19 215 2) Yamazaki et al. (2011), Ibudilast. A mixed PDE3/4 inhibitor, causes a selective and nitric oxide/cGMP-independent relaxation of the intracranial vertebrobasilar artery; Eur. J. Pharmacol., 650 605 3) Cueva Vargas et al. (2016), The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling.; Neurobiol. Dis., 93 156 4) Mizuno et al. (2004), Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia; Neuropharmacology, 46 404 5) Ledeboer et al. (2007), Ibudilast (AV-411). A class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes; Expert. Opin. Investig. Drugs, 16 935

Ibudilast Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 323)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hengmao New Materials Technology CO., LIMITED
+86-0086-1773693-3208 +8617736933208 1137059254@qq.com China 9287 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11001 58
Dorne Chemical Technology co. LTD
+86-13583358881 +86-18560316533 Ethan@dornechem.com China 291 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 product@chemlin.com.cn CHINA 3012 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Jinan Gongchuang Pharmaceutical Technology Co., Ltd.
13287783460 3166282224@qq.com CHINA 10 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58

Related articles

View Lastest Price from Ibudilast manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ibudilast pictures 2024-03-29 Ibudilast
50847-11-5
US $0.00-0.00 / Kg 1Kg 99.9% 200tons airuikechemical co., ltd.
Ibudilast pictures 2024-03-29 Ibudilast
50847-11-5
US $1.00 / g 1g 99% 100kg Dorne Chemical Technology co. LTD
Ibudilast pictures 2024-03-28 Ibudilast
50847-11-5
US $0.00-0.00 / KG 1KG 0.99 10T Shandong Hanjiang Chemical Co., Ltd
  • Ibudilast pictures
  • Ibudilast
    50847-11-5
  • US $0.00-0.00 / Kg
  • 99.9%
  • airuikechemical co., ltd.
  • Ibudilast pictures
  • Ibudilast
    50847-11-5
  • US $1.00 / g
  • 99%
  • Dorne Chemical Technology co. LTD
  • Ibudilast pictures
  • Ibudilast
    50847-11-5
  • US $0.00-0.00 / KG
  • 0.99
  • Shandong Hanjiang Chemical Co., Ltd

Ibudilast Spectrum

IBUDILAST IBUDILAST-D7 KC-404 1-PROPANONE, 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL] 3-Isobutyryl-2-isopropy-lpyrazolo[1,5-α]pyridine Ketas Eyevinal 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methyl-1-propanone Pinatos Ibudilast,2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-Methylpropan-1-one AV 411 Ibudilast (KC-404) 3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO(1,5-A)PYRIDINE 2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]-1-PROPANONE Ibudilast 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one Ibudilast, >=98% budilast 1-propanone 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine KC-404 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone 2-methyl-1-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-1-propanon 5-a)pyridine,3-isobutyryl-2-isopropyl-pyrazolo( lbudilast 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, Ketas 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-α]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-α]pyridine, KC-404, Ketas MN-166 CS-351 -Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone Ibudilast> Ibudilast USP/EP/BP Ibudilast (KC404, AV411, MN166) IbudilastQ: What is Ibudilast Q: What is the CAS Number of Ibudilast Q: What is the storage condition of Ibudilast Q: What are the applications of Ibudilast 50847-11-5 BioChemical Cell Signaling and Neuroscience Cell Biology G Proteins and Cyclic Nucleotides Phosphodiesterase Inhibitors Cyclic Nucleotide Metabolism Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Cyclic Nucleotide related Amines Heterocycles API