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Ibudilast

Ibudilast
Ibudilast structure
CAS No.
50847-11-5
Chemical Name:
Ibudilast
Synonyms
Ketas;KC-404;AV 411;MN-166;CS-351;Pinatos;Eyevinal;budilast;IBUDILAST;lbudilast
CBNumber:
CB0145945
Molecular Formula:
C14H18N2O
Formula Weight:
230.31
MOL File:
50847-11-5.mol

Ibudilast Properties

Melting point:
53-54°C
Boiling point:
175°C/7.5mmHg(lit.)
Density 
1.09
refractive index 
1.5500 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: 28 mg/mL, soluble
pka
1.22±0.30(Predicted)
form 
solid
color 
white
Merck 
14,4879
InChIKey
ZJVFLBOZORBYFE-UHFFFAOYSA-N
CAS DataBase Reference
50847-11-5(CAS DataBase Reference)
FDA UNII
M0TTH61XC5
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  UR0711200
Toxicity LD50 i.v. in mice: 260 mg/kg (Irikura, 1973)

Ibudilast price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I0157 Ibudilast ≥99% (HPLC), solid 50847-11-5 10mg $243 2019-12-02 Buy
Sigma-Aldrich I0157 Ibudilast ≥99% (HPLC), solid 50847-11-5 50mg $931 2019-12-02 Buy
TCI Chemical I0740 Ibudilast >98.0%(HPLC)(T) 50847-11-5 20mg $195 2020-06-24 Buy
TCI Chemical I0740 Ibudilast >98.0%(HPLC)(T) 50847-11-5 100mg $651 2020-06-24 Buy
Cayman Chemical 14832 Ibudilast ≥98% 50847-11-5 1mg $25 2020-06-24 Buy

Ibudilast Chemical Properties,Uses,Production

Description

Ibudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.

Chemical Properties

White Solid

Originator

Kyorin (Japan)

Uses

a phosphodiesterase inhibitor with anti-inflammatory activity

Uses

Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]

Uses

A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)

brand name

Ketas

Biological Activity

Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Ibudilast Preparation Products And Raw materials

Raw materials

Preparation Products


Ibudilast Suppliers

Global( 210)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Gongchuang Pharmaceutical Technology Co., Ltd.
13287783460
3166282224@qq.com CHINA 10 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21837 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 309 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10157 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
whatsapp: +8619930501651 breeduan@crovellbio.com CHINA 2581 58

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View Lastest Price from Ibudilast manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-04 Ibudilast
50847-11-5
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2020-05-08 Ibudilast
50847-11-5
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2019-09-04 Ibudilast
50847-11-5
US $1.00 / KG 1KG 98% 1000KG career henan chemical co

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