Trimeprazine
- CAS No.
- 84-96-8
- Chemical Name:
- Trimeprazine
- Synonyms
- Teralen;Teralene;Alimezine;Bayer 1219;ALIMENAZINE;alimemazine;TRIMEPRAZINE;Trimeperazine;dl-Trimeprazine;Methylpromazine
- CBNumber:
- CB0146078
- Molecular Formula:
- C18H22N2S
- Molecular Weight:
- 298.45
- MDL Number:
- MFCD00242597
- MOL File:
- 84-96-8.mol
- MSDS File:
- SDS
| Melting point | 68°C |
|---|---|
| Boiling point | bp0.3 150-175° |
| Density | 1.1163 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| pka | pKa 9.00 (Uncertain) |
| Water Solubility | 0.942 mg/L |
| CAS DataBase Reference | 84-96-8 |
| FDA UNII | 76H78MJJ52 |
| NIST Chemistry Reference | Trimeprazine(84-96-8) |
| ATC code | R06AD01 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS09,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H318-H301-H411-H317 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P280-P305+P351+P338-P310 |
Trimeprazine Chemical Properties,Uses,Production
Originator
Temaril,SKF,US,1958
Uses
antipruritic
Uses
Trimeprazine is used for treating itching during dermatitis of both allergic and nonallergic origin.
Definition
ChEBI: Trimeprazine is a member of phenothiazines.
Manufacturing Process
95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6
grams) in xylene (140 cc) at a temperature of 130°C and the mixture is
heated with reflux for 2 hours.
A 0.61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in
xylene is then added over 50 minutes and heating with reflux is continued for
20 hours. After cooling, the mixture is treated with water (40 cc) and N
methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated
with aqueous sodium hydroxide (density = 1.33; 10 cc) and extracted with
ether.
The extract is dried over potassium carbonate and evaporated and the residue
is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane
(12.6 grams) is collected, distilling between 150° and 175°C under a pressure
of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal
hydrogen chloride, a hydrochloride is obtained, MP 216° to 217°C.
brand name
Temaril (Allergan).
Therapeutic Function
Antipruritic
Trimeprazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3632 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9358 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
View Lastest Price from Trimeprazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-11 | Trimeprazine
84-96-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-20 | Trimeprazine
84-96-8
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Trimeprazine
84-96-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Trimeprazine
84-96-8
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd