Chinese Japanese Germany

Dexamethasone 21-phosphate disodium salt

Summary Anti-inflammatory drugs Characteristic Pharmacology effect Pharmacokinetics Adverse Reaction Medicine interactions Precautions Special people medication Medication contraindication Dosage Storage Usage References
Dexamethasone 21-phosphate disodium salt
Dexamethasone 21-phosphate disodium salt structure
Chemical Name:
Dexamethasone 21-phosphate disodium salt
Molecular Formula:
Formula Weight:
MOL File:

Dexamethasone 21-phosphate disodium salt Properties

Melting point:
233-235 °C
D +57° (water); D25 +74 ±4° (calcd on water-free and alcohol-free basis, concn of 10 mg/ml): USP XIX, p 124
storage temp. 
H2O: 50 mg/mL, clear, faintly yellow
White Powder
white to off-white
pH(10g/l, 25℃) : 7.5~10.5
Water Solubility 
Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.
CAS DataBase Reference
2392-39-4(CAS DataBase Reference)
EPA Substance Registry System
Pregna-1,4-diene- 3,20-dione, 9-fluoro-11,17-dihydroxy-16- methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.alpha.)-(2392-39-4)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-40-63
Safety Statements  36/37/39
WGK Germany  3
RTECS  TU4056000
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

Dexamethasone 21-phosphate disodium salt price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D1159 Dexamethasone 21-phosphate disodium salt ≥98% 2392-39-4 1g $279 2018-11-20 Buy
Sigma-Aldrich D1159 Dexamethasone 21-phosphate disodium salt ≥98% 2392-39-4 5g $912 2018-11-20 Buy
Alfa Aesar J64083 Dexamethasone 21-phosphate disodium salt, 98% 2392-39-4 5g $321 2018-11-13 Buy
Alfa Aesar J64083 Dexamethasone 21-phosphate disodium salt, 98% 2392-39-4 1g $103 2018-11-13 Buy
Cayman Chemical 20340 Dexamethasone Phosphate (sodium salt) ≥95% 2392-39-4 100mg $25 2018-11-19 Buy

Dexamethasone 21-phosphate disodium salt Chemical Properties,Uses,Production


Dexamethasone 21-phosphate disodium salt is a system glucocorticoid with anti-inflammatory properties, is the pro-drug which is converted to dexamethasone in vivo. It stimulates uptake of glutamine in the cerebral cortex and induces apoptosis. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways.
It is freely soluble in water, slightly soluble in ethanol, and insoluble in chloroform and in ether. It is an inhibitor of the sodium phosphate symporter and GR activator.
Additionally, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.

Anti-inflammatory drugs

Dexamethasone sodium phosphate (DSP), chemical name 16a-methyl-11β,17a,21-trihydroxy-9a-fluoropregna-1,4-diene-3,20-dione-21-Phosphate disodium salt, belongs to the adrenal cortex hormones. It has the effect of antiphlogosis by stabilizing the lysosomal membrane, reducing the release of lysosomal hydrolase; inhibiting the formation of  inflammation-induced material  bradykinin, serotonin and prostaglandin, increasing the stability of mast cells particles, reducing the release of histamine, concentrate blood vessels, stop white blood cells and macrophages from migrating outside of the blood vessels, etc. It can inhibit macrophage function to play immunization function and inhibit the formation of fibroblasts which is conducive to prevent corneal scar. When used for trauma, it can stop scar from forming and protect eyesight. It can inhibit or reduce the formation of new vessel in the cornea and conjunctiva disease and alleviate rejection reaction and scar formation in local use. In clinical treatment it can be used for autoimmune diseases, allergies, inflammation, rheumatism, asthma, ophthalmology and dermatology and other diseases.


This product is white or off-white powder; odorless with slightly bitter taste and hygroscopicity. It can dissolve in water or methanol but is almost insoluble in acetone or ether. Melting point 233-235 ℃.

Pharmacology effect

This product can relieve and prevent the reaction of organization to inflammation. In the early stage of acute inflammation, it can reduce the exudation of local edema by inhibiting capillary permeability, leukocyte infiltration and phagocytosis and reducing the release of various inflammatory mediators In the late inflammatory phase, it can inhibit capillary and fibroblast proliferation and collagen protein synthesis to prevent adhesion and scar formation.
This product can prevent or inhibit cell-mediated immune response, delayed allergic reactions,reduce the number of T lymphocytes, monocytes and brucella cells, reduce the integration ability between immunoglobulin and cell surface receptors and inhibit interleukin synthesis and release, thus inhibting the transformation of T lymphocytes to lymphocyte and pathological changes caused by allergic reactions such as allergic congestion, edema, exudation, rash, smooth muscle spasm, cell damage. and so on. This product also prevents the immune replenishment from getting through the basement membrane and can reduce the complement component and immunoglobulin concentration. In addition it can inhibit the transplant rejection reaction of tissue and organ and has certain short-term effect on autoimmune diseases.
Inhibition of corneal epithelial regeneration, in the cornea, conjunctival disease can inhibit or reduce the formation of new blood vessels.


This product is adrenal corticosteroid drugs. Its effect is similar to  hydrocortisone but stronger with anti-inflammatory effect 40-50 times that of hydrocortisone and more notable effect of anti-inflammatory, anti-allergy, anti-shock than prednisone. It has quick efficacy and less side effects improving the body function in short time especially for the forst aid in critical illnesses.
This product affects sugar metabolism and has strong function of  anti-inflammatory, anti-inflammatory, anti-inflammatory and anti-allergy It  affects water and sodium retention slightly and has strong inhibitory effect on pituitary-adrenal so it just causes slight side effects such as edema, hypertension,muscle weakness and so on. This product transpires through kidneys in urine after metabolic transformation in liver so the drug's plasma half-life can extend for people with liver and renal dysfunction.
The concentration reaches plasma peak one hour after intramuscular and plasma protein binding rate is lower than other corticosteroids drug.

Adverse Reaction

Medicine interactions


Special people medication

This product with teratogenic effect in animal test can increase the probability of placental insufficiency, neonatal weight loss or stillbirth. So the pregnant women should weight advantages and disadvantages before taking it. Nannie receiving high-dose administration should not breast feed, in case of drug transpiring through milk resulting in infant growth inhibition, adrenal function inefficiency and other adverse reactions
Be careful in giving infant adrental cortex hormones administration because it can inhibit infant from growth and development. If long-term use is necessary, short-acting or medium-acting agents should be used instead of long-acting dexamethasone preparations and changes in intracranial pressure should be observed.
Easy to suffer high blood pressure and diabetes. For old patients especially after-menopaue women the osteoporosis.tends to be severer.

Medication contraindication

Patients with allergic history to this product and adrenal corticosteroids should not be permitted and in special case pros and cons should be weighed before use .Pay attention to the deterioration of the disease: It is not suitable for patients with hypertension, thrombosis, stomach and duodenal ulcer, psychosis, electrolyte metabolism, myocardial infarction , visceral surgery, glaucoma and so on.


Eye drops: dexamethasone sodium phosphate eye drops, 5ml: 1.25mg.
Injection: dexamethasone sodium phosphate injection, 1ml: 5mg, 1ml: 2mg.
Dexamethasone sodium phosphate for injection, 10mg (based on dexamethasone sodium phosphate).
New formulation: dexamethasone sodium phosphate temperature-sensitive in situ gel.
dexamethasone sodium phosphate injection
Figure 1 is dexamethasone sodium phosphate injection


Away from light. Sealed. Stored in dry place at 4℃



Chemical Properties

White or almost white, very hygroscopic powder.


glucocorticoid, antiinflammatory


ChEBI: An organic sodium salt which is the disodium salt of dexamethasone phosphate.

brand name

Decadron (Merck); Dexacen (Cent); Dexacort (UCB); Dexair (Pharmafair); Hexadrol (Organon); Maxidex (Alcon).

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route: peritonitis, central nervous system, and gastrointestinal changes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F-, PO,, and Na2O.

Dexamethasone 21-phosphate disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

Dexamethasone 21-phosphate disodium salt Suppliers

Global( 242)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 CHINA 552 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1662 55
Meihua Biological Technology Co.,Ltd
031145896235 CHINA 215 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24118 58
(323) 306-3136
(626) 453-0409 United States 8430 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651 CHINA 898 58

View Lastest Price from Dexamethasone 21-phosphate disodium salt manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Dexamethasone 21-phosphate disodium salt
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-03-15 Glucocorticoid
US $10.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.
2018-03-09 Dexamethasone 21-phosphate disodium salt
US $100.00 / KG 10G 99.9% 100kg/week Hubei XinRunde Chemical Co., Ltd.

2392-39-4(Dexamethasone 21-phosphate disodium salt)Related Search:

Copyright 2017 © ChemicalBook. All rights reserved