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Dexamethasone 21-phosphate disodium salt

CAS No.
2392-39-4
Chemical Name:
Dexamethasone 21-phosphate disodium salt
Synonyms
decadronphosphate;DEXAMETHASON SODIUM PHOSPHATE;DEXAMETHASONE PHOSPHATE SODIUM;Dexamethasone sodium phosphate for peak identification;1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-PHOSPHATE, DISODIUM SALT;Ak-Dex;Baldex;Decdan;dexagro;Dexagel
CBNumber:
CB0153737
Molecular Formula:
C22H28FNa2O8P
Molecular Weight:
516.4
MDL Number:
MFCD00079105
MOL File:
2392-39-4.mol
MSDS File:
SDS
Last updated:2023-09-07 18:57:57

Dexamethasone 21-phosphate disodium salt Properties

Melting point 233-235 °C
alpha D +57° (water); D25 +74 ±4° (calcd on water-free and alcohol-free basis, concn of 10 mg/ml): USP XIX, p 124
storage temp. 2-8°C
solubility H2O: 50 mg/mL, clear, faintly yellow
form White Powder
color white to off-white
PH pH(10g/l, 25℃) : 7.5~10.5
Water Solubility Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.
Merck 13,2960
BRN 6473066
Stability Hygroscopic
InChIKey PLCQGRYPOISRTQ-FCJDYXGNSA-L
CAS DataBase Reference 2392-39-4(CAS DataBase Reference)
FDA UNII AI9376Y64P
EPA Substance Registry System Dexamethasone disodium phosphate (2392-39-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H361d
Precautionary statements  P201-P301+P312+P330-P308+P313
Hazard Codes  Xn
Risk Statements  22-40-63
Safety Statements  36/37/39
WGK Germany  3
RTECS  TU4056000
3-10
TSCA  Yes
HS Code  2937220000
NFPA 704
0
3 0

Dexamethasone 21-phosphate disodium salt price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D1159 Dexamethasone 21-phosphate disodium salt ≥98% 2392-39-4 1g $374 2024-03-01 Buy
Sigma-Aldrich D1159 Dexamethasone 21-phosphate disodium salt ≥98% 2392-39-4 5g $1230 2024-03-01 Buy
Sigma-Aldrich BP108 Dexamethasone sodium phosphate British Pharmacopoeia (BP) Reference Standard 2392-39-4 100MG $252 2023-06-20 Buy
Alfa Aesar J64083 Dexamethasone 21-phosphate disodium salt, 98% 2392-39-4 1g $137 2024-03-01 Buy
Alfa Aesar J64083 Dexamethasone 21-phosphate disodium salt, 98% 2392-39-4 5g $420 2024-03-01 Buy
Product number Packaging Price Buy
D1159 1g $374 Buy
D1159 5g $1230 Buy
BP108 100MG $252 Buy
J64083 1g $137 Buy
J64083 5g $420 Buy

Dexamethasone 21-phosphate disodium salt Chemical Properties,Uses,Production

Summary

Dexamethasone 21-phosphate disodium salt is a system glucocorticoid with anti-inflammatory properties, is the pro-drug which is converted to dexamethasone in vivo. It stimulates uptake of glutamine in the cerebral cortex and induces apoptosis. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways.
It is freely soluble in water, slightly soluble in ethanol, and insoluble in chloroform and in ether. It is an inhibitor of the sodium phosphate symporter and GR activator.
Additionally, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.

Anti-inflammatory drugs

Dexamethasone sodium phosphate (DSP), chemical name 16a-methyl-11β,17a,21-trihydroxy-9a-fluoropregna-1,4-diene-3,20-dione-21-Phosphate disodium salt, belongs to the adrenal cortex hormones. It has the effect of antiphlogosis by stabilizing the lysosomal membrane, reducing the release of lysosomal hydrolase; inhibiting the formation of  inflammation-induced material  bradykinin, serotonin and prostaglandin, increasing the stability of mast cells particles, reducing the release of histamine, concentrate blood vessels, stop white blood cells and macrophages from migrating outside of the blood vessels, etc. It can inhibit macrophage function to play immunization function and inhibit the formation of fibroblasts which is conducive to prevent corneal scar. When used for trauma, it can stop scar from forming and protect eyesight. It can inhibit or reduce the formation of new vessel in the cornea and conjunctiva disease and alleviate rejection reaction and scar formation in local use. In clinical treatment it can be used for autoimmune diseases, allergies, inflammation, rheumatism, asthma, ophthalmology and dermatology and other diseases.

Characteristic

This product is white or off-white powder; odorless with slightly bitter taste and hygroscopicity. It can dissolve in water or methanol but is almost insoluble in acetone or ether. Melting point 233-235 ℃.

Pharmacology effect

  • Antiinflammatory effect
This product can relieve and prevent the reaction of organization to inflammation. In the early stage of acute inflammation, it can reduce the exudation of local edema by inhibiting capillary permeability, leukocyte infiltration and phagocytosis and reducing the release of various inflammatory mediators In the late inflammatory phase, it can inhibit capillary and fibroblast proliferation and collagen protein synthesis to prevent adhesion and scar formation.
  • Immunity inhibition and anti-allergic effects
This product can prevent or inhibit cell-mediated immune response, delayed allergic reactions,reduce the number of T lymphocytes, monocytes and brucella cells, reduce the integration ability between immunoglobulin and cell surface receptors and inhibit interleukin synthesis and release, thus inhibting the transformation of T lymphocytes to lymphocyte and pathological changes caused by allergic reactions such as allergic congestion, edema, exudation, rash, smooth muscle spasm, cell damage. and so on. This product also prevents the immune replenishment from getting through the basement membrane and can reduce the complement component and immunoglobulin concentration. In addition it can inhibit the transplant rejection reaction of tissue and organ and has certain short-term effect on autoimmune diseases.
  • The treatment effect on ophthalmic diseases
Inhibition of corneal epithelial regeneration, in the cornea, conjunctival disease can inhibit or reduce the formation of new blood vessels.

Pharmacokinetics

This product is adrenal corticosteroid drugs. Its effect is similar to  hydrocortisone but stronger with anti-inflammatory effect 40-50 times that of hydrocortisone and more notable effect of anti-inflammatory, anti-allergy, anti-shock than prednisone. It has quick efficacy and less side effects improving the body function in short time especially for the forst aid in critical illnesses.
This product affects sugar metabolism and has strong function of  anti-inflammatory, anti-inflammatory, anti-inflammatory and anti-allergy It  affects water and sodium retention slightly and has strong inhibitory effect on pituitary-adrenal so it just causes slight side effects such as edema, hypertension,muscle weakness and so on. This product transpires through kidneys in urine after metabolic transformation in liver so the drug's plasma half-life can extend for people with liver and renal dysfunction.
The concentration reaches plasma peak one hour after intramuscular and plasma protein binding rate is lower than other corticosteroids drug.

Adverse Reaction

  • The main adverse reactions of this product is concurrent infection, including fungi, tuberculosis, staphylococcus, proteus, pseudomonas aeruginosa and a variety of herpes virus
  • Long-term use can cause iatrogenic Cushing's syndrome.
  •  For patients suffering from chronic wasting disease or mental disorders before, such mental symptoms may occur:euphoria, excitement, delirium, anxiety, orientation disorder or inhibition.
  • Some patients with long-term local drug use may suffer hormone glaucoma and hormone cataracts.
  • Glucocorticoid withdrawal syndrome. Sometimes the patient stop taking medicine may suffer dizziness, fainting tendencies, abdominal pain or back pain, fever, loss of appetite, nausea, vomiting, muscle or joint pain, headache, fatigue, weakness, which can be considered to be glucocorticoid-dependent syndrome adrenal insufficiency and the recurrence of original disease are excluded after careful examination.

Medicine interactions

  • The decomposition of this product can be speeded and metabolic promotion is weakened if taken with barbiturates, phenytoin, rifampicin and other liver enzyme inducer
  • The toxicity increases combined with salicylic acid
  • The product can reduce the effect of anticoagulant and oral hypoglycemic and attention should be paid adjust the dose.
  • Incompatible with hydrochloric vancomycin

Precautions

  • Patients with tuberculosis, acute bacterial or viral infections must be given appropriate anti-infective treatment.
  • For eye infections combined with effective antibiotics. Patients with
  • corneal ulcers are not permitted. When patient’s condition turns better dose times should be gradually reduced in case of recurrence.
  • Patients with diabetes, osteoporosis, cirrhosis, renal dysfunction, and hypothyroidism should be cautious to take.
  • After long-term medication, dosage should be gradually reduced before stop.
  • Athletes with caution.

Special people medication

  • Pregnant women and lactatinal women medication
This product with teratogenic effect in animal test can increase the probability of placental insufficiency, neonatal weight loss or stillbirth. So the pregnant women should weight advantages and disadvantages before taking it. Nannie receiving high-dose administration should not breast feed, in case of drug transpiring through milk resulting in infant growth inhibition, adrenal function inefficiency and other adverse reactions
  • Children medication
Be careful in giving infant adrental cortex hormones administration because it can inhibit infant from growth and development. If long-term use is necessary, short-acting or medium-acting agents should be used instead of long-acting dexamethasone preparations and changes in intracranial pressure should be observed.
  • Old people medication
Easy to suffer high blood pressure and diabetes. For old patients especially after-menopaue women the osteoporosis.tends to be severer.

Medication contraindication

Patients with allergic history to this product and adrenal corticosteroids should not be permitted and in special case pros and cons should be weighed before use .Pay attention to the deterioration of the disease: It is not suitable for patients with hypertension, thrombosis, stomach and duodenal ulcer, psychosis, electrolyte metabolism, myocardial infarction , visceral surgery, glaucoma and so on.

Dosage

Eye drops: dexamethasone sodium phosphate eye drops, 5ml: 1.25mg.
Injection: dexamethasone sodium phosphate injection, 1ml: 5mg, 1ml: 2mg.
Dexamethasone sodium phosphate for injection, 10mg (based on dexamethasone sodium phosphate).
New formulation: dexamethasone sodium phosphate temperature-sensitive in situ gel.
dexamethasone sodium phosphate injection
Figure 1 is dexamethasone sodium phosphate injection

Storage

Away from light. Sealed. Stored in dry place at 4℃

Usage

  • Adrenal corticosteroids drug, anti-inflammatory, anti-toxity, anti-allergy;
  • An anti-excitment glucocorticoid and also a precursor drug that can be converted into dexamethasone in body stimulating glutamate to be absorbed into the cerebral cortex. It is used as adrenal corticosteroids clinically with anti-inflammatory, anti-drug and anti-allergy effect.

References

https://www.alfa.com/zh-cn/catalog/J64083/
http://www.tcichemicals.com/eshop/en/jp/commodity/D4438/
https://www.goldbio.com/product/4827/dexamethasone-21-phosphate-disodium-salt

Chemical Properties

White or almost white, very hygroscopic powder.

Originator

Decadron Phosphate,MS and D,US,1959

Uses

Dexamethasone 21-phosphate disodium salt acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter. It is used in the treatment of emetic effects of cancer therapy and epicondylitis. Further, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.

Uses

Dexamethasone-21-phosphate disodium salt is used in eye and ear preparations and in systemic preparations.

Uses

glucocorticoid, antiinflammatory

Definition

ChEBI: An organic sodium salt which is the disodium salt of dexamethasone phosphate.

Manufacturing Process

A solution of bis-triethylamine phosphate was prepared by slowly adding 2.36 ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml of triethylamine at 20°C. This solution was added to a stirred solution of 4.70 g of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,2-dione 21- methanesulfonate and 20 ml of acetonitrile. The mixture was heated under reflux for four hours and then evaporated under reduced pressure to a volume of 12 ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate triethylamine salt with some inorganic phosphate.
The mixture was cooled, 25 ml of methanol added, and the cooled mixture treated with 33 ml of 1.89 N methanolic sodium methoxide solution. The precipitated inorganic phosphates were removed by suction filtration and washed thoroughly with methanol. The combined filtrates were evaporated under reduced pressure to a volume of 12 ml and treated with 30 ml of methanol. The resulting cloudy solution was clarified by filtration through diatomaceous earth. The volume of the filtrate was brought to 40 ml by the addition of methanol, and 120 ml of ether was added with stirring. The precipitated product, which was 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl1,4-pregnadiene-3,20-dione 21-phosphate sodium salt, was collected by suction filtration, and washed with acetone and then with ether. The weight of the air-dried material was 3.06 g.

brand name

Decadron (Merck); Dexacen (Cent); Dexacort (UCB); Dexair (Pharmafair); Hexadrol (Organon); Maxidex (Alcon).

Therapeutic Function

Glucocorticoid

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route: peritonitis, central nervous system, and gastrointestinal changes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F-, PO,, and Na2O.

Dexamethasone 21-phosphate disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 544)Suppliers
Supplier Tel Email Country ProdList Advantage
APOLLO HEALTHCARE RESOURCES
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career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com China 2931 58

View Lastest Price from Dexamethasone 21-phosphate disodium salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dexamethasone 21-phosphate disodium salt pictures 2024-03-12 Dexamethasone 21-phosphate disodium salt
2392-39-4
US $0.00 / g 1g 98% HPLC 100kg shandong perfect biotechnology co.ltd
Dexamethasone 21-phosphate disodium salt pictures 2024-01-02 Dexamethasone 21-phosphate disodium salt
2392-39-4
US $200.00-1.00 / KG 1KG 99%, 99.5% Sublimated g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
Dexamethasone Sodium Phosphate pictures 2023-11-21 Dexamethasone Sodium Phosphate
2392-39-4
US $1.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.

Dexamethasone 21-phosphate disodium salt Spectrum

dexadreson dexagro dexamethasonedisodiumphosphate disodiumdexamethasonephosphate disodiumsalt,(11beta,16alpha)-y) DEXAMETHASONE 21-PHOSPHATE DISODIUM SALT DEXAMETHASONE PHOSPHATE DISODIUM SALT dexamethasone 21-(disodium phosphate) DEXAMETHASONE SODIM PHOSPHATE Dexamethasone acetate phosphate DEXAMETHASONE 21-PHOSPHATE DISODIUM DEXAMETHASONE SODIUM PHOSPHATE BP STANDARD(CRM STANDARD) DEXAMETHASONE SODIUM PHOSPHATE BP(CRM STANDARD) DEXAMETHASONE SODIUM PHOSPHATE EPD(CRM STANDARD) DEXAMETHASONE SODIUM PHOSPHATE MM(CRM STANDARD) DEXAMETHASONE SODIUM PHOSPHATE WHO(CRM STANDARD) DexamethasoneSodiumPhosphateBp Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.alpha.)- DEXAMETHASONESODIUMPHOSPHATE,POWDER,USP Ak-Dex Baldex Colvasone Corson (pharmaceutical) Dalalone Decdan Dexabene Dexagel Dexamethasone phosphate sodium salt Dexamethazone sodium phosphate Disodium dexamethasone 21-monophosphate Disodium dexamethasone 21-phosphate Maxidex Ointment Orgadrone Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11β,16α)- Dexamethasone 21-Phosphate Disodium Salt Hydrate Dexamethasone Sodium Phosphate (350 mg) Dexamethasone 21-phosphate disodium salt, >=98% 9-FLUORO-11 BETA,17 ALPHA,21-TRIHYDROXY-16 ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-21-(DIHYDROGENPHOSPHATE)DIS Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(dihydrogen phosphate) disodium salt 21-Phosphate disodium salt megacort pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonoox sodiumdexamethasonephosphate soldesam solu-decadron spersadox 9α-Fluoro-16α-methyl-3,20-dioxo-1,4-pregnadiene-11β,17α,21-triol 21-(phosphoric acid disodium) salt Phosphoric acid 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxo-1,4-pregnadien-21-yldisodium salt Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(dihydrogen phosphate) disodium salt (8CI) Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-phosphate disodium salt (6CI) Solu-Deca 9-Fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione disodium salt disodium [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate disodium [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate disodium [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-3-keto-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] phosphate Dexamethasone Sodium Phosphate USP (powder) DexaMethasone 21-phosphate disodiu DexaMethasone SodiuM Phosphate USP