ChemicalBook
Chinese Japanese Germany Korea

Donepezil

Donepezil
Donepezil structure
CAS No.
120014-06-4
Chemical Name:
Donepezil
Synonyms
n-1-one;Donezepil;DONEPEZIL;Donepenil;AKOS 226-23;Donepezil, >=99%;Aricept(Donepezil);2-[(1-Benzyl-4-piper;Donepezil HCl (Base);Donepezil InterMediate
CBNumber:
CB0156314
Molecular Formula:
C24H29NO3
Formula Weight:
379.49
MOL File:
120014-06-4.mol

Donepezil Properties

Melting point:
207°C
Boiling point:
527.9±50.0 °C(Predicted)
Density 
1.141±0.06 g/cm3(Predicted)
pka
8.84±0.10(Predicted)
Water Solubility 
2.931 mg/L
CAS DataBase Reference
120014-06-4(CAS DataBase Reference)
FDA UNII
8SSC91326P
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-36/37/39
RIDADR  UN 2811
HS Code  29333990

Donepezil price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13245 Donepezil ≥95% 120014-06-4 10mg $25 2018-11-13 Buy
Cayman Chemical 13245 Donepezil ≥95% 120014-06-4 25mg $59 2018-11-13 Buy
Cayman Chemical 13245 Donepezil ≥95% 120014-06-4 50mg $99 2018-11-13 Buy
Cayman Chemical 13245 Donepezil ≥95% 120014-06-4 100mg $188 2019-12-02 Buy

Donepezil Chemical Properties,Uses,Production

Uses

Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.[Cayman Chemical]

Definition

ChEBI: Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.

brand name

Aricept (Eisai Medical Research).

General Description

Donepezil, (±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one (Aricept), commonly referred to in the literature asE2020, is a reversible inhibitor of AChE. It is indicated forthe treatment of symptoms of mild-to-moderate Alzheimerdisease. Donepezil is approximately 96% bound to plasmaproteins, with an elimination half-life of 70 hours. It is metabolizedprincipally by the 2D6 and 3A4 isozymes of theP450 system.

Donepezil Preparation Products And Raw materials

Raw materials

Preparation Products


Donepezil Suppliers

Global( 229)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19923 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3015 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24697 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30052 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23979 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23048 58
Shandong chuangyingchemical Co., Ltd.
13156170209
sale@chuangyingchem.com CHINA 4403 58

View Lastest Price from Donepezil manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-17 donepezil
120014-06-4
US $1.00 / Kg/Drum 1KG 99% 9999tons Shandong Kangmailin Chemical Technology Co. Ltd..
2018-12-22 2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
120014-06-4
US $7.00 / kg 1kg 99% 100KG career henan chemical co

120014-06-4(Donepezil)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved