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Donepezil

Donepezil
Donepezil structure
CAS No.
120014-06-4
Chemical Name:
Donepezil
Synonyms
n-1-one;Donezepil;DONEPEZIL;Donepenil;Donepezilo;Donepezine;AKOS 226-23;Donepezil, >=99%;DONEPEZIL(E 2020);Aricept(Donepezil)
CBNumber:
CB0156314
Molecular Formula:
C24H29NO3
Formula Weight:
379.49
MOL File:
120014-06-4.mol

Donepezil Properties

Melting point:
207°C
Boiling point:
527.9±50.0 °C(Predicted)
Density 
1.141±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
8.84±0.10(Predicted)
Water Solubility 
2.931 mg/L
CAS DataBase Reference
120014-06-4(CAS DataBase Reference)
FDA UNII
8SSC91326P
NCI Dictionary of Cancer Terms
donepezil
ATC code
N06DA02
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-36/37/39
RIDADR  UN 2811
HS Code  29333990

Donepezil price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13245 Donepezil ≥95% 120014-06-4 10mg $25 2021-12-16 Buy
Cayman Chemical 13245 Donepezil ≥95% 120014-06-4 25mg $59 2021-12-16 Buy
TRC D525745 Donepezil 120014-06-4 500mg $210 2021-12-16 Buy
ChemScene CS-2866 Donepezil 99.96% 120014-06-4 100mg $222 2021-12-16 Buy
American Custom Chemicals Corporation API0002476 ARICEPT 95.00% 120014-06-4 250MG $933.24 2021-12-16 Buy

Donepezil Chemical Properties,Uses,Production

Description

Donepezil is another “nonclassic,” centrally acting, reversible, noncompetitive AChEI that was approved in 1997 for treatment of mild-to-moderate AD and dementia. Its selectivity for AChE is 570- to 1,250-fold that for butyrylcholinesterase, and it also exhibits greater affinity for brain AChE than for AChE in the periphery.

Uses

Donepezil is a cholinesterase inhibitors.

Uses

Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.[Cayman Chemical]

Definition

ChEBI: Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.

brand name

Aricept (Eisai Medical Research).

General Description

Donepezil, (±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one (Aricept), commonly referred to in the literature asE2020, is a reversible inhibitor of AChE. It is indicated forthe treatment of symptoms of mild-to-moderate Alzheimerdisease. Donepezil is approximately 96% bound to plasmaproteins, with an elimination half-life of 70 hours. It is metabolizedprincipally by the 2D6 and 3A4 isozymes of theP450 system.

Metabolism

When compared to tacrine, donepezil exhibits greater CNS AChE selectivity, longer elimination half-life (70–104 hours in subjects older than 55 years) and little or no potential for hepatotoxicity. Donepezil is metabolized by CYP2D6 and CYP3A4 via demethylation, debenzylation, hydroxylation, oxidation to the cis-N-oxide, and glucuronidation. The 6-O-desmethyl metabolite accounts for 11% of a dose, and it exhibits AChE inhibitory activity comparable to that of the parent compound.

Donepezil Preparation Products And Raw materials

Raw materials

Preparation Products


Donepezil Suppliers

Global( 298)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9128 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3283 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1011 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5942 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58

View Lastest Price from Donepezil manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-20 Donepezil
120014-06-4
US $100.00 / KG 1KG 99% 5tons Shanxi Naipu Import and Export Co.,Ltd
2022-01-19 donepezil
120014-06-4
US $19.00 / Kg/Bag 1Kg/Bag 99% 20tons Hong Kong Tiansheng New Material Trading Co., Ltd
2022-01-19 donepezil
120014-06-4
US $5.99 / KG 1KG 99% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd

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