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2'',3'',5''-Triacetyl -azacytidine

2'',3'',5''-Triacetyl -azacytidine structure

CAS No.: 10302-78-0

Chemical Name:: 2'',3'',5''-Triacetyl -azacytidine

Synonyms: Nsc291930;-O-triacetate;Triacetyl azacitidine;Azacitidine Triacetate;Azacitidine Impurity 48;Intermediate of Azacitidine;2'3'5'-triacetyl-5-Azacytosine;2',3',5'-triacetyl-5-Azacytidine;2',3',5'-Tri-O-Acetyl-Azacytidine;2'',3'',5''-Triacetyl -azacytidine

CBNumber:: CB01564248

Molecular Formula:: C14H18N4O8

Molecular Weight:: 370.31

MDL Number:: MFCD11113159

MOL File:: 10302-78-0.mol

Last updated:2023-09-20 16:43:00

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2'',3'',5''-Triacetyl -azacytidine Properties

Boiling point	497.3±55.0 °C(Predicted)
Density	1.60±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form	crystalline solid
pka	3.06±0.20(Predicted)
CAS DataBase Reference	10302-78-0

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

2'',3'',5''-Triacetyl -azacytidine price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	13373	2',3',5'-triacetyl-5-Azacytidine ≥95%	10302-78-0	5mg	$62	2024-03-01	Buy
Cayman Chemical	13373	2',3',5'-triacetyl-5-Azacytidine ≥95%	10302-78-0	10mg	$115	2024-03-01	Buy
Cayman Chemical	13373	2',3',5'-triacetyl-5-Azacytidine ≥95%	10302-78-0	50mg	$477	2024-03-01	Buy
Cayman Chemical	13373	2',3',5'-triacetyl-5-Azacytidine ≥95%	10302-78-0	100mg	$834	2024-03-01	Buy
TRC	A796030	5-Azacytidine2’,3’5’-O-triacetate	10302-78-0	50mg	$265	2021-12-16	Buy

Product number	Packaging	Price	Buy
13373	5mg	$62	Buy
13373	10mg	$115	Buy
13373	50mg	$477	Buy
13373	100mg	$834	Buy
A796030	50mg	$265	Buy

2'',3'',5''-Triacetyl -azacytidine Chemical Properties,Uses,Production

Description

5-Azacytidine is an inhibitor of DNA methyltransferase, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.

Chemical Properties

White to off-white powder

Uses

5-Azacytidine is an inhibitor of DNA methyltransferaes, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.[Cayman Chemical]

in vivo

in cd-1 mice, oral administration of tac for five days per week for 2 weeks didn’t result in animal deaths and weight loss, but induced changes in hematological parameters, lymph nodes, bone marrow, and duodenal epithelium. tac inhibited global dna methylation in the spleen and gut. in an in vivo l1210 leukemia model, tac exhibited antineoplastic activity [1].

References

[1] ziemba a, ramirez m c, freeman b, et al. abstract# 3369: development of oral demethylating agents for the treatment of myelodysplastic syndrome[j]. 2009.
[2] brueckner b, boy r g, siedlecki p, et al. epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human dna methyltransferases[j]. cancer research, 2005, 65(14): 6305-6311.

2'',3'',5''-Triacetyl -azacytidine Preparation Products And Raw materials

Raw materials

Preparation Products

2'',3'',5''-Triacetyl -azacytidine Suppliers

Global( 96)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9352	55
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9641	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3465	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4022	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Antai Fine Chemical Technology Co.,Limited	58
Hubei Ipure Biology Co., Ltd	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	58
BOC Sciences	58

View Lastest Price from 2'',3'',5''-Triacetyl -azacytidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-09-27	2'',3'',5''-Triacetyl -azacytidine 10302-78-0	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2'',3'',5''-Triacetyl -azacytidine
10302-78-0
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

2'',3'',5''-Triacetyl -azacytidine Spectrum

2'',3'',5''-Triacetyl -azacytidine(10302-78-0)¹HNMR

10302-78-0(2'',3'',5''-Triacetyl -azacytidine)Related Search:

Fazarabine Azacitidine Impurity 34 L-Cytidine 1-(diaminomethylidene)-3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]urea 1,2,3,5-TETRA-O-ACETYL-BETA-L-XYLOFURANOSE

Azacitidine Impurity 31 AMMELINE Azacitidine Impurity 33 5,6-dihydro-5-azacytidine Ammeline-13C3

5-Azacitidine 5'-Diphosphate (2-aminoethyl)carbamic acid Diazenecarboximidamide, N-(hydroxymethyl)-N-β-D-ribofuranosyl- 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one β-D-Glucopyranose, 2-deoxy-2-[[[(1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl)amino]thioxomethyl]amino]-

Azacitidine Impurity 30 Azacitidine Impurity 41 5-Aza-2'-deoxycytidine

1of4

2'',3'',5''-Triacetyl -azacytidine 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-o-acetyl-.beta.-D-ribofuranosyl)- Nsc291930 S-Triazin-2(1H)-one, 4-amino-1-.beta.-D-ribofuranosyl-, triacetate (ester) 2',3',5'-triacetyl-5-Azacytidine 1,3,5-Triazin-2(1H)-one, 4-aMino-1-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)- (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate Intermediate of Azacitidine 2'3'5'-triacetyl-5-Azacytosine 2',3',5'-Tri-O-Acetyl-Azacytidine Azacitidine Triacetate Triacetyl azacitidine 2,3,5-tri-O-acetyl-β-D-ribofuranose-4-amino-1,3,5-triazine 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)- -O-triacetate 4-Amino-1-(2,3,5-tri-o-acetyl-beta-d-ribofuranosyl)-1,3,5-triazin-2(1h)-one 5-Azacytidine 2’,3’5’-O-triacetate 2,3,5-tri-O-acetyl-β-D-ribofuranose-4-amino-1,3,5-triazine Azacitidine Impurity 48 10302-78-0