MESORIDAZINE
- CAS No.
- Chemical Name:
- MESORIDAZINE
- Synonyms
- CBNumber:
- CB0157447
- Molecular Formula:
- C21H26N2OS2
- Molecular Weight:
- 386.57
- MDL Number:
- MFCD00866645
- MOL File:
- Mol file
| Melting point | 126 - 131°C (dec.) |
|---|---|
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | Acetonitrile (Slightly), DMSO (Slightly, Heated), Methanol (Slightly) |
| form | Solid |
| color | Pale Yellow to Orange |
| Stability | Hygroscopic |
| FDA UNII | 5XE4NWM740 |
| ATC code | N05AC03 |
MESORIDAZINE Chemical Properties,Uses,Production
Uses
Antipsychotic.
Uses
Mesoridazine acts analogous to other phenothiazine neuroleptics and is used for schizophrenia, behavioral problems, psychoneurotic displays, and in severe and chronic alcoholism.
brand name
Lidanar (Novartis).
Synthesis
Mesoridazine, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylsufinyl)phenothiazine (6.1.13), is synthesized by an analogous scheme, however, it is also synthesized
by alkylating the acidic form of 2-methylthiphenothiazine—methylsulfonylphenothiazine —
using 2-(2-chlorethyl)-1-methylpiperidine.
In order to do this, 2-methylthiophenothiazine is initially acylated at the nitrogen atom
using acetic anhydride, giving 10-acetyl-2-methylthiophenothiazine (6.1.10). The resulting acetyl derivative is further oxidized by hydrogen peroxide into 10-acetyl-2-methylsulfonylpenothiazine (6.1.11). Deacylation of this product in potassium carbonate methanol
solution gives 2-methylsulfonylphenothiazine (6.1.12), which is alkylated by 2-(2-chlorethyl)-1-methylpiperidine in the presence of sodium amide, affording the desired mesoridazine (6.1.13) [31].
MESORIDAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
MESORIDAZINE Suppliers
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|---|---|---|---|---|---|
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