ChemicalBook
Chinese Japanese Germany

Gallic acid

Gallic acid
Gallic acid structure
CAS No.
149-91-7
Chemical Name:
Gallic acid
Synonyms
gallic;BETZ 0276;Gallussaure;GALLIC ACID;AKOS 214-65;Gallic acid 0;graphite oxide;graphitic acid;kyselinagallova;Galloyl alcohol
CBNumber:
CB0158671
Molecular Formula:
C7H6O5
Formula Weight:
170.12
MOL File:
149-91-7.mol

Gallic acid Properties

Melting point:
252 °C (dec.)(lit.)
Boiling point:
259.73°C (rough estimate)
Density 
1.694
refractive index 
1.5690 (estimate)
storage temp. 
Store below +30°C.
form 
Powder
pka
4.41(at 25℃)
color 
Off-white
Water Solubility 
12 g/L cold water
Merck 
14,4345
BRN 
2050274
Stability:
Stability Stable, but may discolour upon exposure to light. Hygroscopic. Incompatible with strong oxidizing agents, strong bases, acid chlorides, acid anhydrides.
InChIKey
LNTHITQWFMADLM-UHFFFAOYSA-N
CAS DataBase Reference
149-91-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 3,4,5-trihydroxy-(149-91-7)
EPA Substance Registry System
Benzoic acid, 3,4,5-trihydroxy-(149-91-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25-37/39
WGK Germany  2
RTECS  LW7525000
8-9-23
TSCA  Yes
HS Code  29182900
Hazardous Substances Data 149-91-7(Hazardous Substances Data)
Toxicity LD50 in rabbits (g/kg): 5.0 orally (Dollahite)
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Gallic acid price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 91215 Gallic acid certified reference material, TraceCERT 149-91-7 100mg $91.6 2018-11-13 Buy
Sigma-Aldrich G7384 Gallic acid 97.5-102.5% (titration) 149-91-7 1kg $348 2018-11-13 Buy
Alfa Aesar B24887 3,4,5-Trihydroxybenzoic acid, anhydrous, 99% 149-91-7 1000g $196 2018-11-13 Buy
Alfa Aesar B24887 3,4,5-Trihydroxybenzoic acid, anhydrous, 99% 149-91-7 250g $64.5 2018-11-13 Buy
Cayman Chemical 11846 Gallic Acid ≥98% 149-91-7 10g $25 2018-11-13 Buy

Gallic acid Chemical Properties,Uses,Production

Chemical Properties

Colorless crystalline needles or prisms obtained from nutgall tannins,gallic acid is soluble in water and alcohol and melts at 235 to 240 °C. Also known as trihydroxybenzoic acid, it is used in photography, tanning, ink manufacture and pharmaceuticals.

Uses

antineoplastic, astringent, antibacterial

Uses

A cyclooxygease inhibitor substance found in plants.

Uses

gallic acid is a potential bleaching agent and anti-oxidant, it is also astringent and potentially anti-microbial and anti-fungal. Scientists are finding that gallic acid may serve as a skin-lightening agent by inhibiting the action of the tyrosinase and peroxidase enzymes. Some studies indicate that it is more effective than hydroquinone when combined with the proper ingredients. It is also incorporated into anti-aging formulations for its ability to prevent mucopolysaccaride deterioration. It is a constituent of witch hazel and oak bark, among many other plants; however, it is generally obtained from nutgalls for commercial purposes.

Definition

ChEBI: A trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5.

Uses

Gallic acid is a trihydroxybenzoic acid found in many plants as either the free acid or in the esterified form of gallotannins and ellagitannins. It demonstrates antioxidant activity by scavenging 2,2-diphenyl-1-picrylhydrazyl and hydroxyl free radicals with IC50 values of 9.4 and 191 μM, respectively, and inhibiting microsomal lipid peroxidation with an IC50 value of 1.51 μM. Gallic acid is often used as a standard for determining the phenol content of various analytes by the Folin-Ciocalteau assay where results are reported in gallic acid equivalents.[Cayman Chemical]

Biotechnological Production

The production of gallic acid is challenging. Conventionally, it has been produced by acid hydrolysis of tannic acid. However, this process is expensive due to low yields and high impurities. To overcome this problem, microbial production of gallic acid has been suggested. For example, in a solid-state fermentation of Teri pod cover powder containing tannin using Rhizopus oryzae, a yield of 90.9 % based on the tannin content of 58 % of the substrate was observed. In a submerged culture of Aspergillus aceleatus DBF9 growing on a medium with 3 % tannin, a maximal product concentration of 6.8 g.L-1 was reported. With tannic acid, even higher product concentrations of up to 25 g.L-1, a yield of 0.83 g of gallic acid per gram of tannic acid, and a productivity of 0,56 g.L-1.h-1 were shown using Apergillus fischeri MTCC 150 in submerged cultivation. An alternative is the enzymatic hydrolysis of tannic acids using tannase produced by microorganisms (e.g. Aspergillus fischeri or R. oryzae). For example, propyl gallate could be produced using a tannase from Emericela nidulans immobilized on ionic and covalent supports.

General Description

Odorless white solid. Sinks in water.

Air & Water Reactions

Sparingly water soluble

Reactivity Profile

Phenols, such as Gallic acid, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid.

Health Hazard

Inhalation of dust may irritate nose and throat. Contact with eyes or skin causes irritation.

Fire Hazard

Flash point data for Gallic acid are not available. Gallic acid is probably combustible.

Purification Methods

Crystallise gallic from water. The tri-O-acetyl derivative has m 172o (from MeOH), and the anilide has m 207o(from EtOH). [Beilstein 10 H 470, 10 IV 1993.]

Gallic acid Preparation Products And Raw materials

Raw materials

Preparation Products


Gallic acid Suppliers

Global( 332)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1662 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1374 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2238 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20243 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 4525 58
Jinan Tenglong Chemical Co.,Ltd
Whatsapp:+8615563263311 Skype:live:smions7080
smions7080@gmail.com CHINA 770 58

View Lastest Price from Gallic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-26 Gallic acid
149-91-7
US $100.00 / KG 1KG 97% customise career henan chemical co

Gallic acid Spectrum


149-91-7(Gallic acid)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved