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Cyclohexapentylose structure
Chemical Name:
fadex;Alfadex;Cavamax? W6;Alfadex CRS;alpha-Dextrin;α-Cydodextrin;α-cyclodextrin;Ncgc00090767-01;a-Cyclodextrin.;CYCLOHEXAAMYLOSE
Molecular Formula:
C36 H60 O30
Formula Weight:
MOL File:

Cyclohexapentylose Properties

Melting point:
>278 °C (dec.) (lit.)
Boiling point:
784.04°C (rough estimate)
[α]D25 +146~+151° (c=1, H2O) (After Drying)
1.2580 (rough estimate)
refractive index 
1.7500 (estimate)
storage temp. 
H2O: 50 mg/mL
5.0-8.0 (1% in solution)
optical activity
[α]20/D +136±3°, c = 10% in H2O
Water Solubility 
Soluble in water at 1%(w/v)
Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference
EWG's Food Scores
NIST Chemistry Reference
EPA Substance Registry System
.alpha.-Cyclodextrin (10016-20-3)
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  GU2292000
HS Code  29400090

Cyclohexapentylose price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 28705 α-Cyclodextrin purum, ≥98.0% (HPLC) 10016-20-3 5g $65.4 2021-12-16 Buy
Sigma-Aldrich PHR2560 Alpha Cyclodextrin 10016-20-3 1G $179 2021-12-16 Buy
Sigma-Aldrich A1225000 Alfadex European Pharmacopoeia (EP) Reference Standard 10016-20-3 $190 2021-12-16 Buy
Sigma-Aldrich 1154558 Alpha Cyclodextrin United States Pharmacopeia (USP) Reference Standard 10016-20-3 500mg $414 2021-12-16 Buy
TCI Chemical C0776 Alpha Cyclodextrin >98.0%(HPLC) 10016-20-3 10g $62 2021-12-16 Buy

Cyclohexapentylose Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder

Chemical Properties

Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.


also available in pharma grade


A naturally occuring clathrate.


Useful for selective precipitation of enantiomeric, positional or structural isomersα-Cyclodextrin is used as a fiber ingredient, an odor or flavor masking agent. It is also useful for emulsification applications. It is also used as whipping fiber and emulsifying fiber. It finds application in medical, healthcare and food and beverage applications. It is also used to lower blood low-density lipoprotein cholesterol levels and lower blood triglyceride levels. It plays an essential role in fat free or fat containing dessert compositions and also employed for the reduction or the replacement of egg white in confectionary and bakery applications. Further, it acts as a supramolecular carrier, complexing agent and controlled drug release. In addition to this, it is used to increase the insulin and leptin sensitivity.

Production Methods

Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.

General Description

Hexagonal plates or blade-shaped needles.

Reactivity Profile

Cyclohexapentylose has hydrophobic cavities. Cyclohexapentylose forms inclusion compounds with organic substances, salts, and halogens in the solid state or in aqueous solutions. Cyclohexapentylose is incompatible with strong oxidizing agents.

Fire Hazard

Flash point data for Cyclohexapentylose are not available; however, Cyclohexapentylose is probably combustible.

Pharmaceutical Applications

Cyclodextrins are ‘bucketlike’ or ‘conelike’ toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex.
Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability.
Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material.
a-Cyclodextrin is used mainly in parenteral formulations. However, as it has the smallest cavity of the cyclodextrins it can form inclusion complexes with only relatively few, small-sized molecules. In contrast, g-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules; it has low toxicity and enhanced water solubility.
In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent.
In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as corticosteroids. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation.
Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.


Cyclodextrins are starch derivatives and are mainly used in oral and parenteral pharmaceutical formulations. They are also used in topical and ophthalmic formulations.
Cyclodextrins are also used in cosmetics and food products, and are generally regarded as essentially nontoxic and nonirritant materials. However, when administered parenterally, β-cyclodextrin is not metabolized but accumulates in the kidneys as insoluble cholesterol complexes, resulting in severe nephrotoxicity.
Cyclodextrin administered orally is metabolized by microflora in the colon, forming the metabolites maltodextrin, maltose, and glucose; these are themselves further metabolized before being finally excreted as carbon dioxide and water. Although a study published in 1957 suggested that orally administered cyclodextrins were highly toxic, more recent animal toxicity studies in rats and dogs have shown this not to be the case, and cyclodextrins are now approved for use in food products and orally administered pharmaceuticals in a number of countries.
Cyclodextrins are not irritant to the skin and eyes, or upon inhalation. There is also no evidence to suggest that cyclodextrins are mutagenic or teratogenic.
LD50 (rat, IP): 1.0 g/kg(15)
LD50 (rat, IV): 0.79 g/kg


Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.

Purification Methods

Recrystallise α-cyclodextrin from 60% aqueous EtOH, then twice from water, and dry it for 12hours in a vacuum at 80o. It is also purified by precipitation from water with 1,1,2-trichloroethylene. The precipitate is collected, washed and resuspended in water. This is boiled to steam distil the trichloroethylene. The solution is then freeze-dried to recover the cyclodextrin. [Armstrong et al. J Am Chem Soc 108 1418 1986]. [Beilstein 19/12 V 789.]

Regulatory Status

Included in the FDA Inactive Ingredients Database: α-cyclodextrin (injection preparations); β-cyclodextrin (oral tablets, topical gels); γ-cyclodextrin (IV injections).
Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.

Cyclohexapentylose Preparation Products And Raw materials

Raw materials

Preparation Products

Cyclohexapentylose Suppliers

Global( 319)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd.
0543 2605568 CHINA 46 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 15421 58
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 9150 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 26782 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418697 China 3000 55
career henan chemical co
+86-0371-55982848 China 29953 58
+86 18953170293
+86 0531-67809011 CHINA 2940 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Henan Xiangtong Chemical Co., Ltd.
86-371-86017988 CHINA 293 58
Shandong chuangyingchemical Co., Ltd.
18853181302 CHINA 5917 58

View Lastest Price from Cyclohexapentylose manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-03 alpha-cyclodextrin
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
2021-12-01 Cyclohexapentylose
US $15.60 / KG 1KG 99% 5000kg Hebei Crovell Biotech Co Ltd
2021-11-02 Cyclohexapentylose
US $65.00 / KG 1KG 99 8000T Baoji Guokang Healthchem co.,ltd

Cyclohexapentylose Spectrum

10016-20-3(Cyclohexapentylose)Related Search:

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