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18-HYDROXY-11-DEOXYCORTICOSTERONE

18-HYDROXY-11-DEOXYCORTICOSTERONE
18-HYDROXY-11-DEOXYCORTICOSTERONE structure
CAS No.
379-68-0
Chemical Name:
18-HYDROXY-11-DEOXYCORTICOSTERONE
Synonyms
18-HYDROXY DOC;18-HYDROXYDEOXYCORTICOSTERONE;4-PREGNEN-18,21-DIOL-3,20-DIONE;4-PREGNENE-18,21-DIOL-3,20-DIONE;18-HYDROXY-11-DEOXYCORTICOSTERONE;11-DEOXY-18-HYDROXYCORTICOSTERONE;18,21-dihydroxypregn-4-ene-3,20-dione;18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE;Pregn-4-ene-3,20-dione, 18,21-dihydroxy-;18,20-EPOXY-20,21-DIHYDROXY-4-PREGNEN-3-ONE
CBNumber:
CB0164085
Molecular Formula:
C21H30O4
Formula Weight:
346.46
MOL File:
379-68-0.mol

18-HYDROXY-11-DEOXYCORTICOSTERONE Properties

Melting point:
171-173 °C
storage temp. 
2-8°C
SAFETY
  • Risk and Safety Statements
Safety Statements  22-24/25

18-HYDROXY-11-DEOXYCORTICOSTERONE price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10007851 18-hydroxy-11-deoxy Corticosterone 379-68-0 500μg $75 2021-12-16 Buy
Cayman Chemical 10007851 18-hydroxy-11-deoxy Corticosterone 379-68-0 1mg $143 2021-12-16 Buy
TRC D239680 11-Deoxy-18-hydroxycorticosterone 379-68-0 1mg $235 2021-12-16 Buy
AK Scientific 3712CA 18,21-Dihydroxypregn-4-ene-3,20-dione 379-68-0 1mg $293 2021-12-16 Buy
American Custom Chemicals Corporation CHM0006430 18-HYDROXY-11-DEOXYCORTICOSTERONE 95.00% 379-68-0 1MG $679.14 2021-12-16 Buy

18-HYDROXY-11-DEOXYCORTICOSTERONE Chemical Properties,Uses,Production

Description

18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; Item No. 24257) as well as angiotensin II (Item No. 17150), which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; Item No. 22916) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone (Item No. 15876) and can be converted to aldosterone (Item No. 15273) by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.

Uses

11-Deoxy-18-hydroxycorticosterone is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.

Purification Methods

Recrystallise 18-hydroxy-11-deoxycorticosterone from Et2O/Me2CO to give crystals m 200-205o. When it is recrystallised from M2CO, it has m 191-195o. It has UV with max at 240nm. The 21-O-acetoxy-18-hydroxy derivative has m 158-159o (from Et2O/*C6H6), and the 21-O-acetoxy-18,20-epoxy derivative has m 149-154o (from Et2O). [Kahnt et al. Helv Chim Acta 38 1237 1955; Pappo J Am Chem Soc 81 1010 1959.]

18-HYDROXY-11-DEOXYCORTICOSTERONE Preparation Products And Raw materials

Raw materials

Preparation Products


18-HYDROXY-11-DEOXYCORTICOSTERONE Suppliers

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