18-HYDROXY-11-DEOXYCORTICOSTERONE
- CAS No.
- 379-68-0
- Chemical Name:
- 18-HYDROXY-11-DEOXYCORTICOSTERONE
- Synonyms
- 18-HYDROXY DOC;18-HYDROXYDEOXYCORTICOSTERONE;4-PREGNEN-18,21-DIOL-3,20-DIONE;4-PREGNENE-18,21-DIOL-3,20-DIONE;18-HYDROXY-11-DEOXYCORTICOSTERONE;11-DEOXY-18-HYDROXYCORTICOSTERONE;18,21-dihydroxypregn-4-ene-3,20-dione;18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE;Pregn-4-ene-3,20-dione, 18,21-dihydroxy-;18,20-EPOXY-20,21-DIHYDROXY-4-PREGNEN-3-ONE
- CBNumber:
- CB0164085
- Molecular Formula:
- C21H30O4
- Molecular Weight:
- 346.46
- MDL Number:
- MFCD00010486
- MOL File:
- 379-68-0.mol
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|
18-HYDROXY-11-DEOXYCORTICOSTERONE price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R200077 | 18,20-EPOXY-20,21-DIHYDROXYPREGN-4-EN-3-ONE AldrichCPR | 379-68-0 | 1MG | $134 | 2023-06-20 | Buy |
| Cayman Chemical | 10007851 | 18-hydroxy-11-deoxy Corticosterone | 379-68-0 | 1mg | $176 | 2024-03-01 | Buy |
| Cayman Chemical | 10007851 | 18-hydroxy-11-deoxy Corticosterone | 379-68-0 | 500μg | $75 | 2021-12-16 | Buy |
| TRC | D239680 | 11-Deoxy-18-hydroxycorticosterone | 379-68-0 | 1mg | $235 | 2021-12-16 | Buy |
| AK Scientific | 3712CA | 18,21-Dihydroxypregn-4-ene-3,20-dione | 379-68-0 | 1mg | $293 | 2021-12-16 | Buy |
18-HYDROXY-11-DEOXYCORTICOSTERONE Chemical Properties,Uses,Production
Description
18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; ) as well as angiotensin II , which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; ) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone and can be converted to aldosterone by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.
Uses
11-Deoxy-18-hydroxycorticosterone is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.
Definition
ChEBI: 18-hydroxydeoxycorticosterone is a 21-hydroxy steroid, a 3-oxo-Delta(4) steroid, a 20-oxo steroid and a 18-hydroxy steroid.
Purification Methods
Recrystallise 18-hydroxy-11-deoxycorticosterone from Et2O/Me2CO to give crystals m 200-205o. When it is recrystallised from M2CO, it has m 191-195o. It has UV with max at 240nm. The 21-O-acetoxy-18-hydroxy derivative has m 158-159o (from Et2O/*C6H6), and the 21-O-acetoxy-18,20-epoxy derivative has m 149-154o (from Et2O). [Kahnt et al. Helv Chim Acta 38 1237 1955; Pappo J Am Chem Soc 81 1010 1959.]
18-HYDROXY-11-DEOXYCORTICOSTERONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 | 1046@dideu.com | China | 10009 | 58 |
| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 15900491054 | info@scrbio.com | China | 9260 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |