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5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride structure
CAS No.
138982-67-9
Chemical Name:
5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
Synonyms
CP-88059-1;ZIPRASIDONE HCL;Ziprasidong Hcl;ZIPRASIDONE INTERMEDIATE;ZIPRASIDONE HYDROCHLORIDE;ZIPRASITONE HCl MONOHYDRATE;ZIPRASIDONE HCL MONOHYDRATE;Geodon Hydrochloride Hydrate;Ziprasidone Hydrochloride (200 mg);Ziprasidone Hydrochloride Mohydrate
CBNumber:
CB0166832
Molecular Formula:
C21H24Cl2N4O2S
Formula Weight:
467.41186
MOL File:
138982-67-9.mol

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride Properties

Melting point:
300°C
storage temp. 
Room temp
solubility 
DMSO: >10mg/mL
form 
solid
Merck 
14,10171
CAS DataBase Reference
138982-67-9(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Safety Statements  24/25
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  NM3241200
HS Code  38220010
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Z2777 Ziprasidone hydrochloride monohydrate ≥98% (HPLC), solid 138982-67-9 5mg $87.5 2018-11-20 Buy
Sigma-Aldrich 1724408 Ziprasidone hydrochloride United States Pharmacopeia (USP) Reference Standard 138982-67-9 200mg $348 2018-11-13 Buy
TCI Chemical Z0032 Ziprasidone Hydrochloride Monohydrate >98.0%(HPLC) 138982-67-9 50mg $40 2018-11-22 Buy
TCI Chemical Z0032 Ziprasidone Hydrochloride Monohydrate >98.0%(HPLC) 138982-67-9 250mg $132 2018-11-22 Buy
Cayman Chemical 15031 Ziprasidone (hydrochloride hydrate) ≥98% 138982-67-9 10mg $63 2018-11-13 Buy

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Pale Tan Powder

Uses

Combined serotonin (5HT2) and dopamine (D2) receptor antagonist. Used as an antipsychotic.

Uses

antipsychotic;Dopamine D2/serotonin 5-HT2 antagonist

Uses

Ziprasidone Hydrochloride is the hydrochloride salt of a benzisothiazolylpiperazine analog structurally related to the atypical antipsychotic drug tiospirone that antagonizes both central serotonin 5-HT2A (Ki = 0.42 nM) and dopamine D2 (Ki = 4.8 nM) receptors. It is also a potent agonist at 5-HT1A receptors (Ki = 3.4 nM), increasing cortical dopamine release which may offset negative effects associated with dopamine D2 antagonism, and an inverse agonist at 5-HT1B and 5-HT1D receptors (pKis = 8.8 and 8.6, respectively).[Cayman Chemical]

Definition

ChEBI: The hydrochloride hydrate salt of ziprasidone.

brand name

Geodon (Pfizer).

Biological Activity

Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT 2A receptors with a 5-HT 2A /D 2 affinity ratio greater than any other clinically available atypical antipsychotics (pK i values are 9.38, 8.88, 8.69, 8.47, 8.32, 8.14, 7.98, 7.49, 7.33 and 6.28 for 5-HT 2A , 5-HT 2C , 5-HT 1D , 5-HT 1A , D 2 , D 3 , α 1 , D 4 , H 1 and D 1 receptors respectively).

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride Suppliers

Global( 180)Suppliers
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Henan DaKen Chemical CO.,LTD.
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86-21-50328109 3bsc@sina.com China 15884 69

View Lastest Price from 5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-08 5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
138982-67-9
US $1.00 / KG 1KG 99% 1000kg career henan chemical co

138982-67-9(5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride)Related Search:


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