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COLISTIN

Neurotoxicity and Nephrotoxicity
COLISTIN
COLISTIN structure
CAS No.
1066-17-7
Chemical Name:
COLISTIN
Synonyms
COLISTIN;totazina;kangdisu;colomycin;colimycin;kolimitsin;colymysins;coly-mycin;Aids033059;colisticina
CBNumber:
CB0169873
Molecular Formula:
C52H98N16O13
Formula Weight:
1155.43
MOL File:
1066-17-7.mol

COLISTIN Properties

Boiling point:
807.67°C (rough estimate)
Density 
1.1050 (rough estimate)
refractive index 
1.6700 (estimate)
CAS DataBase Reference
1066-17-7
SAFETY
  • Risk and Safety Statements
RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III

COLISTIN price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23487 Colistin ≥95% 1066-17-7 25mg $89 2018-11-19 Buy
Cayman Chemical 23487 Colistin ≥95% 1066-17-7 100mg $285 2018-11-19 Buy

COLISTIN Chemical Properties,Uses,Production

Neurotoxicity and Nephrotoxicity

Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.

Uses

Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect.

brand name

Coly-Mycin (Monarch).

COLISTIN Preparation Products And Raw materials

Raw materials

Preparation Products


COLISTIN Suppliers

Global( 30)Suppliers
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Shenzhen Nexconn Pharmatechs Ltd
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QUALITY CONTROL CHEMICALS INC.
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BOC Sciences
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Nanjing Sunlida Biological Technology Co., Ltd. 025-58378339;025-57798810
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ChemStrong Scientific Co.,Ltd 0755 66853366
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Hubei Jusheng Technology Co.,Ltd North:18871490274,QQ:1400878000 South:18871490354,QQ:1400868000
FAX:1400878000 sales@hubeijusheng.com China 9866 58
Alta Scientific Co., Ltd. (0086) 22-6537-8550; 185-2256-9193; 185-2256-9194
(0086) 22-2532-9655 contact@altascientific.com China 8312 55
Alfa Chemistry 1-201-478-8534
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