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COLISTIN

Neurotoxicity and Nephrotoxicity
COLISTIN
COLISTIN structure
CAS No.
1066-17-7
Chemical Name:
COLISTIN
Synonyms
COLISTIN;kangdisu;totazina;colimycin;colomycin;Aids033059;coly-mycin;colymysins;kolimitsin;Aids-033059
CBNumber:
CB0169873
Molecular Formula:
C52H98N16O13
Formula Weight:
1155.43
MOL File:
1066-17-7.mol

COLISTIN Properties

Boiling point:
807.67°C (rough estimate)
Density 
1.1050 (rough estimate)
refractive index 
1.6700 (estimate)
CAS DataBase Reference
1066-17-7
EWG's Food Scores
1
FDA UNII
Z67X93HJG1
NCI Drug Dictionary
Coly-Mycin
ATC code
A07AA10,J01XB01
SAFETY
  • Risk and Safety Statements
RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III

COLISTIN price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001999 Colistin for system suitability European Pharmacopoeia (EP) Reference Standard 1066-17-7 y0001999 $128.9 2020-08-18 Buy
Sigma-Aldrich Y0001999 Colistin for system suitability European Pharmacopoeia (EP) Reference Standard 1066-17-7 $128.9 2021-03-22 Buy
Cayman Chemical 23487 Colistin ≥95% 1066-17-7 100mg $285 2021-03-22 Buy
Cayman Chemical 23487 Colistin ≥95% 1066-17-7 25mg $89 2021-03-22 Buy

COLISTIN Chemical Properties,Uses,Production

Neurotoxicity and Nephrotoxicity

Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.

Uses

Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect.

brand name

Coly-Mycin (Monarch).

COLISTIN Preparation Products And Raw materials

Raw materials

Preparation Products


COLISTIN Suppliers

Global( 66)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
+86 15821988213 info@longyupharma.com China 2473 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29864 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
0551-65418697 sales@tnjchem.com CHINA 37441 58
Wuhan Mulei New Material Technology Co. Ltd
+8619831950597
Telegram/wickr: jane8886 betty@whmulei.com;amy@whmulei.com;jane@whmulei.com China 993 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9938 58
Hebei Qige Biological Technology Co. Ltd
8618733132031
qige01@hbqige.com CHINA 1322 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58

View Lastest Price from COLISTIN manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-06 amoxicillin
1066-17-7
US $20.00 / Kg/Drum 25Kg/Drum 99.99% 1 ton per week Wuhan Mulei New Material Technology Co. Ltd
2021-07-20 Colistin sulphate
1066-17-7
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2021-06-23 COLISTIN USP/EP/BP
1066-17-7
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited

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