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Calcitriol

Introduction References
Calcitriol
Calcitriol structure
CAS No.
32222-06-3
Chemical Name:
Calcitriol
Synonyms
Silkis;ro215535;Panbonis;Calcijex;Soltriol;Toptriol;rocaltrol;Rocalirol;Solbone P;Calcitrio
CBNumber:
CB0171027
Molecular Formula:
C27H44O3
Formula Weight:
416.64
MOL File:
32222-06-3.mol

Calcitriol Properties

Melting point:
119-1210C
alpha 
D25 +48° (methanol)
Boiling point:
474.91°C (rough estimate)
Density 
1.0362 (rough estimate)
refractive index 
1.4700 (estimate)
Flash point:
14 °C
storage temp. 
2-8°C
solubility 
Do you have solubility information on this product that you would like to share
form 
Solid
pka
14.43±0.40(Predicted)
λmax
265nm(lit.)
Merck 
14,1644
BRN 
7559394
Stability:
Air and Light Sensitive
InChIKey
GMRQFYUYWCNGIN-UNVJKIGWSA-N
CAS DataBase Reference
32222-06-3(CAS DataBase Reference)
FDA UNII
FXC9231JVH
NCI Dictionary of Cancer Terms
calcitriol
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS06,GHS08,GHS07
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370-H300-H319
Precautionary statements  P210-P280-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235-P305+P351+P338-P337+P313
Hazard Codes  T+,Xn,F
Risk Statements  26/27/28-63-36/37/38-20/21/22-11
Safety Statements  36/37/39-45-36-26-16-7
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS  FZ4645000
8-10-19
HazardClass  6.1(a)
PackingGroup  I
HS Code  29061900

Calcitriol price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1086312 Calcitriol solution United States Pharmacopeia (USP) Reference Standard 32222-06-3 5ml $454 2020-08-18 Buy
Sigma-Aldrich 17936 1α,25-Dihydroxyvitamin D3 ≥97.0% (HPLC) 32222-06-3 1mg-f $1540 2020-08-18 Buy
TCI Chemical C3078 Calcitriol >97.0%(HPLC) 32222-06-3 1mg $719 2020-06-24 Buy
Cayman Chemical 71820 Calcitriol ≥97% 32222-06-3 1mg $68 2020-06-24 Buy
Cayman Chemical 71820 Calcitriol ≥97% 32222-06-3 5mg $255 2020-06-24 Buy

Calcitriol Chemical Properties,Uses,Production

Introduction

Calcitriol (1,25-dihydroxylcholecaldiferol) is a steroid hormone with three hydroxyl groups, which is an active metabolite and the most effective form of vitamin D. It is produced primarily in the kidney when the blood calcium level and parathyroid hormone are low. Calcitriol promotes the calcium and phosphorus absorption in the intestine, reabsorption in the kidneys. Along with parathyroid hormone, it regulates bone growth for building and keeping strong bones. Calcitriol is used to treat and prevent low levels of calcium and bone disease in patients whose kidneys or parathyroid glands are not working normally, to treat secondary hyperparathyroidism and metabolic bone disease in people with kidney disease. Calcitriol may also be chemopreventive for colon and prostate cancers as it induces cell cycle arrest, cell differentiation, and apoptosis.

References

  1. https://pubchem.ncbi.nlm.nih.gov
  2. https://medlineplus.gov
  3. http://flexikon.doccheck.com/en/Calcitriol
  4. https://en.wikipedia.org/wiki/Calcitriol
  5. https://www.webmd.com

Description

Calcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus.
Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.
Calcitriol-dimensional molecular structure
Calcitriol-dimensional molecular structure
The above information is edited by the chemicalbook of Dai Xiongfeng.

Chemical Properties

White Crystalline Powder

Originator

Rocaltrol,Roche,US,1978

Uses

The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic

Uses

Calcitriol (1α,25-dihydroxy Vitamin D3) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.[Cayman Chemical]

Uses

Calcium regulator, anti-psoriatic

Uses

Vitamin medicines; it can be used for treating the renal bone malnutrition of patients with chronic renal failure;

Definition

ChEBI: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the li er to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.

Manufacturing Process

1α,25-Dihydroxyprecholecalciferol: A solution of 1α,25- diacetoxyprecholecalciferol (0.712 g, 1.42 mmols), potassium hydroxide (2.0 g, 35.6 mmols) and methanol (40 ml) was stirred at room temperature under argon for 30 hours. The reaction mixture was concentrated under reduced pressure. Water (50 ml) was added to the residue and the mixture was extracted with methylene chloride (3 x 100 ml). The combined organic extracts were washed with saturated sodium chloride solution (3 x 50 ml), dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to give 0.619 g of 1alpha,25-dihydroxyprecholecalciferol as a thick oil.
1α,25-Dihydroxycholecalciferol: A solution of 1α,25-dihydroxyprecholecalciferol [0.619 g in dioxane (30 ml)] was heated under reflux for 30 minutes under an atmosphere of argon. The reaction mixture was concentrated under reduced pressure and the residue was purified with a Waters Associates liquid chromatograph model 202 using a 8 foot * 3/8 inch Porasil A column and a 5:1 mixture of ethyl acetate-n-hexane as the eluent to give 0.474 g (80% yield based on 1α,25-diacetoxyprecholecalciferol) of pure 1α,25- dihydroxycholecalciferol. Recrystallization from methyl formate afforded 0.340 g of 1α,25-dihydroxcholecalciferol as colorless crystals, MP 113°-114°C.

brand name

Calcijex (Abbott); Rocaltrol (Roche.

Therapeutic Function

Calcium regulator

Biological Activity

Active metabolite of vitamin D 3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca 2+ absorption and regulates bone Ca 2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Veterinary Drugs and Treatments

Calcitriol may be potentially beneficial in the adjunctive treatment of chronic renal disease in dogs and cats but its use is somewhat controversial, particularly the decision on how soon in the course of chronic renal insufficiency it should employed. It may also be of benefit in treating some types of dermatopathies (primary idiopathic seborrhea).

Calcitriol Preparation Products And Raw materials

Raw materials

Preparation Products


Calcitriol Suppliers

Global( 320)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21841 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22624 55
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3048 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24886 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30039 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
QQ:800182836 stella@zetchem.com CHINA 2886 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58

View Lastest Price from Calcitriol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-09-04 Calcitriol
32222-06-3
US $1.00 / KG 1KG 99% Customized career henan chemical co

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