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Bimatoprost

Glaucoma Drug Side effects Glaucoma commonly used drugs Bimatoprost - timolol maleate compound eye drops
Bimatoprost
Bimatoprost structure
CAS No.
155206-00-1
Chemical Name:
Bimatoprost
Synonyms
Bima;LUMIGAN;BiMapnost;Prostamide;BIMATOPROST;BIMATOPROST(TM);Bimatoprost API;buprostaglandin;cGMP Bimatoprost;Bimatoprost (W.S)
CBNumber:
CB0171421
Molecular Formula:
C25H37NO4
Formula Weight:
415.57
MOL File:
155206-00-1.mol

Bimatoprost Properties

Melting point:
66-68°C
Boiling point:
629.8±55.0 °C(Predicted)
Density 
1.145±0.06 g/cm3(Predicted)
storage temp. 
−20°C
pka
14.25±0.20(Predicted)
form 
solid
InChIKey
AQOKCDNYWBIDND-FTOWTWDKSA-N
CAS DataBase Reference
155206-00-1(CAS DataBase Reference)
FDA UNII
QXS94885MZ
SAFETY
  • Risk and Safety Statements
WGK Germany  3

Bimatoprost price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P6740 17-Phenyl-tri-norprostaglandin F2α-ethyl amide ≥95%, solid 155206-00-1 1mg $134 2019-12-02 Buy
Cayman Chemical 16820 17-phenyl trinor Prostaglandin F2α ethyl amide ≥97% 155206-00-1 5mg $203 2018-11-13 Buy
Cayman Chemical 16820 17-phenyl trinor Prostaglandin F2α ethyl amide ≥97% 155206-00-1 1mg $45 2018-11-13 Buy
Cayman Chemical 16820 17-phenyl trinor Prostaglandin F2α ethyl amide ≥97% 155206-00-1 10mg $293 2018-11-13 Buy
Cayman Chemical 16820 17-phenyl trinor Prostaglandin F2α ethyl amide ≥97% 155206-00-1 50mg $731 2019-12-02 Buy

Bimatoprost Chemical Properties,Uses,Production

Glaucoma Drug

Bimatoprost is a synthetic amide F2α derivative ,it can selectively simulate the effect forefront amines produced by the body, which make aqueous humor production rate increase aqueous outflow resistance is reduced, by increasing the amount of aqueous outflow of the uveoscleral and trabecular Netcom channel to reduce intraocular pressure (IOP),it is considered to be the most effective hypotensive drug of topical ocular anti-glaucoma drugs,it is suitable for the treatment of open-angle glaucoma (POAG) or invalid elevated intraocular other ocular hypotensive medications compression syndrome (OHT) patients.

Side effects

1. to deepen the color of the iris, blepharitis, eye irritation and pain; black eyelashes thicker growth; conjunctival hyperemia, temporarily punctate corneal epithelial erosion, eyelid edema and erythema; rash.
2. rare respiratory disorders, asthma exacerbations, iritis, uveitis, eyelid skin darkening.
3. very rare chest pain, pharyngitis.
4. eye itching, allergic conjunctivitis, cataract, conjunctival edema, secretions, photophobia, superficial punctate keratitis, headache, high blood pressure.

Glaucoma commonly used drugs

1. prostaglandin derivatives such as latanoprost (Xalatan), bimatoprost (trade name Lumigan) and travoprost (Travatan) can increase outflow of aqueous humor uveoscleral . Bimatoprost also increases trabecular outflow.
2. topical β-adrenergic such as timolol, levobunolol (Betagan), and betaxolol can decrease receptor antagonist of aqueous humor production of ciliary body .
3. Alpha2-adrenergic agonists such as brimonidine (Alphagan) with dual working mechanism, can reduce aqueous humor production and increase trabecular outflow.
4. one case of the selective reduction similar to epinephrine and dipivefrin (Propine) increase outflow of aqueous humor through trabecular meshwork and possibly through uveoscleral outflow pathway, probably by a β2-agonist action.
5. miotic agents (parasympathomimetics), if ciliary muscle contraction Roca works, it can tighten the trabecular and allow increaseing outflow of aqueous humor. Ecothiopate is used for chronic glaucoma.
6. dorzolamide (Trusopt), brinzolamide (Azopt), by inhibiting carbonic anhydrase acetazolamide of ciliary body, reduce aqueous humor secretion of carbonic anhydrase inhibitors.
7. Physostigmine is also used to treat glaucoma and delayed gastric emptying.
The above information is edited by the Chemicalbook of Tian Ye.

Bimatoprost - timolol maleate compound eye drops

In July 2006 , bimatoprost-timolol maleate compound eye drops developed by the United States company obtained approval from the European drug regulatory authority for reducing intraocular pressure or ocular hypertension of open-anglepatients glaucoma patients who do not respond adequately to the β-blockers or prostaglandin like treatment .
The compound eye drops containing 0.03% bimatoprost and 0.5% timolol maleate, once a day administration is able to provide clinically effective pressure control, the effect is better than single Bima latanoprost or timolol maleate. Clinical trials prove that the drug has an excellent tolerability, including the incidence of ocular hyperemia40% lower compared to single bimatoprost .

Description

Bimatoprost was first introduced in the US and Brazil as Lumigan?, an ophthalmic solution (0.03%) for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, a proven risk of glaucomatous visual field loss. Bitamoprost is a new agent belonging to the PGF analog class of prostamides launched in this indication after latanoprost, the most efficaceous topical medication currently available. This synthetic fatty acid amide can be prepared by esterification of 17- phenyl-18,19,20-trinorprostaglandin F followed by ethylamidation. Bimatoprost, as related prostamides, is devoid of typical activities associated with PGF2,, analogs; it exhibits a unique pharmacological profile in contracting the feline iris sphincter with an EC50 of 34 nM without interacting with any known prostanoid receptors. Thus it mimics the action of endogenous prostamides on specific receptors that lower IOP by increasing aqueous humor outflow through both pressure-insensitive and pressure-sensitive pathways without reducing humor formation. In a 3-month controlled clinical trial of efficacy and safety in patients with elevated IOP, bimatoprost demonstrated lower mean intraocular pressures at every time point throughout the study, as well as a good tolerance and systemic safety profile compared to latanoprost.

Chemical Properties

Crystalline Solid

Originator

Allergan (US)

Uses

Antiglaucoma. Synthetic prostamide; structurally related to prostaglandin F2a.

Uses

Antiglaucoma. Synthetic prostamide; structurally related to prostaglandin F2α.

Uses

Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It ha

Uses

Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.

Uses

17-phenyl trinor Prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide) is an F-series PG analog which has been approved for use as an ocular hypotensive drug. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 μg/g corneal tissue/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.[Cayman Chemical]

brand name

Lumigan (Allergan).

General Description

Bimatoprost (Lumigan) is supplied as a sterile 0.03%ophthalmic solution in 2.5- and 5.0-mL sizes. The recommendeddosage of bimatoprost is limited to one drop intothe affected eye once daily in the evening. Increased usagemay decrease its beneficial effect. If used concurrently withother IOP-lowering drugs, a waiting period of 5 minutesshould separate administrations.

Bimatoprost Preparation Products And Raw materials

Raw materials

Preparation Products


Bimatoprost Suppliers

Global( 315)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai finete Pharmaceutical Co., Ltd.
+86-18221039705
- sales@finetechpharm.com CHINA 139 55
Kono Chem Co., Ltd
+86-132 8924 6953(Whatsapp/Wechat)
+86-29-86107037 info@konochemical.com CHINA 2995 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3221 55
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales03@yibaibiotech.com CHINA 420 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21829 58
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3015 60
Anhui Royal Chemical Co., Ltd.
+86-025-86655873
marketing@royal-chem.com CHINA 537 55
Hebei Minshang Biotechnology Co., Ltd
+86-13582176207
coco@hbhuanhao.com CHINA 288 58

Related articles


View Lastest Price from Bimatoprost manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-03 Bimatoprost
155206-00-1
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-12-27 bimatoprost
155206-00-1
US $0.10-0.10 / KG 10g 99%+ 10000KG Shaanxi Dideu Medichem Co. Ltd
2020-03-05 Bimatoprost
155206-00-1
US $1.00 / KG 1KG 99% 200kgs Career Henan Chemical Co

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